A5039996746- Rabies epidemiology and control
- Semiconductor materials and devices
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Viral Infections and Outbreaks Research
- RNA modifications and cancer
- Gyrotron and Vacuum Electronics Research
- Photonic and Optical Devices
- Renal and related cancers
- Virology and Viral Diseases
- CAR-T cell therapy research
- Nuclear Structure and Function
- Optical Network Technologies
- Physics of Superconductivity and Magnetism
- Laser Material Processing Techniques
- Catalytic Processes in Materials Science
- Ammonia Synthesis and Nitrogen Reduction
- Ubiquitin and proteasome pathways
- Molten salt chemistry and electrochemical processes
- Retinopathy of Prematurity Studies
- Nuclear Receptors and Signaling
- Ocular and Laser Science Research
- Natural Compounds in Disease Treatment
- Melamine detection and toxicity
Zhongda Hospital Southeast University
2025
Chongqing University
2025
Shenzhen Luohu People's Hospital
2019-2024
Shenzhen University
2022-2024
Hunan University
2024
Huazhong University of Science and Technology
1991-2023
Jianghan University
2022
Shandong University of Traditional Chinese Medicine
2021
China National Pharmaceutical Group Corporation (China)
2019
University of Georgia
2018
Mesangial cells-mediated glomerulonephritis is a frequent cause of end-stage renal disease. Here, we show that celastrol effective in treating both reversible and irreversible mesangioproliferative rat models, but find its off-target distributions severe systemic toxicity. We thus target to mesangial cells using albumin nanoparticles. Celastrol-albumin nanoparticles crosses fenestrated endothelium accumulates cells, alleviating proteinuria, inflammation, glomerular hypercellularity,...
Since December 2019, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) pandemic in China and worldwide. New drugs for treatment of COVID-19 are urgent need. Considering long development time new drugs, identification promising inhibitors from FDA-approved is an imperative valuable strategy. Recent studies have shown that S1 S2 subunits spike protein SARS-CoV-2 utilize human angiotensin-converting enzyme 2 (hACE2) as...
Cellular therapy based on mesenchymal stem cells (MSCs) is a promising novel therapeutic strategy for the osteonecrosis of femoral head (ONFH), which gradually becoming popular, particularly early-stage ONFH. Nonetheless, MSC-based challenging due to certain limitations, such as limited self-renewal capability cells, availability donor MSCs, and costs involved in screening. As an alternative approach, MSCs derived from induced pluripotent (iPSCs), may lead further standardized-cell...
Central nervous system injury and neurodegenerative diseases cause irreversible loss of neurons. Overexpression exogenous specific transcription factors can reprogram somatic cells into functional neurons for regeneration reconstruction. However, these practices are potentially problematic due to the integration vectors host genome. Here, we showed that activation endogenous genes Ngn2 Isl1 by CRISPRa enabled reprogramming mouse spinal astrocytes embryonic fibroblasts motor These induced...
Decellularized cardiac extracellular matrix (cECM) has been widely considered as an attractive scaffold for engineered tissue (ECT), however, its application is limited by immunogenicity and shortage of organ donation. Skeletal ECM (sECM) readily available shows similarities with cECM. Here we hypothesized that sECM might be alternative ECT strategies.Murine ventricular anterior tibial muscles were sectioned into 300 mm-thick, then cECM acquired pretreatment/SDS/TritonX-100...
Skeletal muscle-secreted myokines widely participate in lipids metabolism through autocrine, paracrine and endocrine actions. The represented by FGF21 Irisin can promote the browning of adipocytes serve as promising targets for treating obesity. Although recombinant replacement therapy AAV (adeno-associated virus)-based overexpression have shown a definite effect ameliorating obesity, novel myokine activation strategies with higher efficacy safety are still pressing need. This study aimed to...
To have a better understanding of the prevalence rabies virus (RABV) in dog trading markets Plateau State Nigeria, total 532 brain samples collected between 2010 and 2011 were subjected to antigen detection molecular characterization. RABV was detected 92 out (17.3%) from two major commercial Nigeria by direct fluorescence antibody assay, indicating possibility high markets. The complete genomic sequence obtained one these positive samples. overall organization this (DRV-NG11) typical all...
Scandia-doped-impregnated (SDI) cathodes were fabricated with scandia-doped tungsten powders using spray drying (SD) combined two-step reduction in hydrogen atmosphere. The temperature-programmed results show that the addition of Sc <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> leads to a decrease temperature oxide powders. Using obtained homogenous distribution nanosized scandia,...
Proposed and demonstrated is a novel scheme of dual-channel-output all-optical logic AND gate. Using cascaded sum- difference-frequency generation in periodically poled lithium niobate (PPLN) waveguide, 20 Gbit/s operation with dual-channel outputs successfully observed the experiment.
Abstract Neurotropic viruses, such as the rabies virus (RABV) and Japanese encephalitis (JEV), induce neuronal dysfunction complication, causing damage. Currently, there are still no effective clinical treatments for injury caused by neurotropic viruses. Memantine, a drug capable of passing through blood‐brain barrier, noncompetitively reversibly binds to n ‐methyl‐ d ‐aspartic acid (NMDA) receptors. Memantine is used treat Alzheimer's disease blocking activation extra axonal ion channels,...
A novel tunable grating exhibiting a linear dispersion in channel is designed and fabricated for the first time. The equivalent chirp formed through chirping of sampling function sampled Bragg grating. period order millimeter, which can be easily controlled. By employing grating, 50-km single-mode fiber completely compensated 10-Gb/s transmission with power penalty -0.7 dB.
A regular micro-apparatus covered with periodic nanohole, nanoridge, and ripple structures on silicon bulk (with crystal orientation of 110) was formed by micromachining a tightly focused beam femtosecond laser wavelength 800 nm, repetition rate 1 kHz, pulse length 130 fs in air. We used direct writing technology to form double-row nanohole structures, the 10× focusing objective lens (NA=0.3). investigated relationship between width speed processing provide knowledge evolution nanoridge structures.
In this work, the effect of doping with 5% to 20% Poly Zinc Acrylate complexes (PZA) on MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> phase formation was studied. The changes lattice parameter and amount substituted Carbon, microstructure as well critical current temperature (T xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) density (J bulk have been studied systematically. DTA-TG IR results show that PZA decomposed between...
The development of the neuromuscular junction depends on signaling processes that involve protein phosphorylation. Motor neuron releases agrin to activate muscle Dok-7, a key tyrosine kinase essential for formation mature and functional junction. However, cascade downstream Dok-7 remains poorly understood. In this study, we combined clustered regularly interspaced short palindromic repeats/Cas9 technique quantitative phosphoproteomics analysis study phosphorylation events triggered by...
More attention was paid to the fact that columnar defects generated by introducing nano-particles into YBCO films can improve in-field superconducting properties of as pinning centers. Epitaxial with self-assembled Yttrium-stabilized Zirconia (YSZ) have been successfully prepared TFA-MOD based on different solutions and effect nano-particle dopants field investigated analyzing results obtained PPMS according Bean Model. The critical current densities (J <sub...
Abstract Significant progress has been made in the diagnosis and treatment of drug‐resistant highly recurrent refractory T cell acute lymphoblastic leukemia (T‐ALL). Primary tumor cell‐derived induced pluripotent stem cells (iPSCs) have become very useful models for cancer research including drug sensitivity tests. In present study, we investigated mechanism underlying resistance T‐ALL using T‐ALL‐derived iPSCs (T‐iPSCs) model. were transformed iPSC reprogramming factors (Sox‐2, Klf4, Oct4,...