A5060660743- Potato Plant Research
- Plant Pathogens and Resistance
- Photosynthetic Processes and Mechanisms
- Prostate Cancer Treatment and Research
- Antioxidant Activity and Oxidative Stress
- Plant biochemistry and biosynthesis
- Algal biology and biofuel production
- Prostate Cancer Diagnosis and Treatment
- Plant nutrient uptake and metabolism
- Plant and animal studies
- Cancer Genomics and Diagnostics
- Plant Disease Resistance and Genetics
- Genetic Associations and Epidemiology
- Plant Molecular Biology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Crystallography and molecular interactions
- Plant Stress Responses and Tolerance
- Animal and Plant Science Education
- Microbial Metabolites in Food Biotechnology
- Plant Parasitism and Resistance
- Plant Pathogens and Fungal Diseases
- Chemical Thermodynamics and Molecular Structure
- X-ray Diffraction in Crystallography
University of Pretoria
2023
The University of Sydney
2023
Garvan Institute of Medical Research
2023
Sefako Makgatho Health Sciences University
2023
Stellenbosch University
2023
University of Limpopo
2023
James Hutton Institute
2013-2022
Kalafong Hospital
2021-2022
United States Department of Agriculture
1967-2010
Agricultural Research Service
2010
Abstract The factors that regulate storage organ carotenoid content remain to be fully elucidated, despite the nutritional and economic importance of this class compound. Recent findings suggest pool size is determined, at least in part, by activity cleavage dioxygenases. aim study was investigate whether Carotenoid Cleavage Dioxygenase4 (CCD4) affects potato (Solanum tuberosum) tuber content. Microarray analysis revealed elevated expression CCD4 gene mature tubers from white-fleshed...
Potato production is often constrained by abiotic stresses such as drought and high temperatures which are present in combination. In the work, we aimed to identify key mechanisms processes underlying single combined stress tolerance comparative analysis of tolerant susceptible cultivars. Physiological data indicated that cultivars Desiree Unica were while Agria Russett Burbank susceptible. Abiotic caused a greater reduction photosynthetic carbon assimilation was associated with lower leaf...
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages
Summary Strigolactones ( SL s) are a class of phytohormones controlling shoot branching. In potato S olanum tuberosum ), tubers develop from underground stolons, diageotropic stems which originate basal stem nodes. As the degree stolon branching influences number and size distribution tubers, it was considered timely to investigate effects production on development tuber life cycle. Transgenic plants were generated in CAROTENOID CLEAVAGE DIOXYGENASE 8 CCD ) gene, key biosynthetic pathway,...
Astaxanthin from Haematococcus pluvialis is commercially produced in a two-stage process, involving green vegetative (macrozooid) and red aplanospore stages. This approach has been scaled up to an industrial process but constraints limit its commercial success profitability, including: contamination issues, high pigment extraction costs, requirements for light levels photo-bleaching the stage. However, addition stage, this alga can produce astaxanthin palmelloid motile macrozooid cells. In...
Seven silver salts of even-numbered n-fatty acids were investigated by X-rays at 20 and 78° C. Their unit cells determined from powder photographs; they proved to be triclinic with two molecules salt per cell. At 20° the cell varies gradually chain length a = 4.588, b 4.016, c 20.41 A., α 101° 12′, β 102° 28′, γ 80° 4′ for caproate, 4.693, 4.120, 50.35 104° 35′, 93° 59′, 76° 1′ stearate. Changes unit-cell dimensions temperature have been observed. A packing in is suggested.
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common variants contributing to multiethnic polygenic score, with rare focused on panel roughly 20 pathogenic genes. Based this knowledge, we are unable determine or differentiate status interrogating whole genome data 113 Black South men. To further assess potentially functional variant...
SUMMARY Potato tuber formation is a secondary developmental programme by which cells in the subapical stolon region divide and radially expand to further differentiate into starch‐accumulating parenchyma. Although some details of molecular pathway that signals tuberisation are known, important gaps our knowledge persist. Here, role member TERMINAL FLOWER 1 / CENTRORADIALIS gene family (termed StCEN ) negative control demonstrated for what thought be first time. It shown reduced expression...
Summary To produce commercially valuable ketocarotenoids in Solanum tuberosum , the 4, 4′ β‐oxygenase ( crtW ) and 3, 3′ β‐hydroxylase (c rtZ genes from Brevundimonas spp. have been expressed plant host under constitutive transcriptional control. The CRTW CRTZ enzymes are capable of modifying endogenous carotenoids to form a range hydroxylated ketolated derivatives. (cv. Désirée) produced significant levels nonendogenous carotenoid products all tissues, but at apparent expense economically...
For many potato cultivars, tuber yield is optimal at average daytime temperatures in the range 14-22 °C. Above this range, reduced for most cultivars. We previously reported that moderately elevated temperature increases steady-state expression of core circadian clock gene TIMING OF CAB EXPRESSION 1 (StTOC1) developing tubers, whereas StSP6A tuberization signal reduced, along with yield. In study we provide evidence StTOC1 links environmental signalling by suppressing autoactivation stolons....
Solanesol is a high value 45-carbon, unsaturated, all-trans-nonaprenol isoprenoid. Recently solanesol has received particular attention because of its utility, both in own right and as precursor the production numerous compounds used treatment disease states. found mainly solanaceous crops such potato, tomato, tobacco pepper where it accumulates foliage. There considerable potential to explore extraction from these sources valuable co-product. In this study we have characterised genetic...
Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such exclude for ancestral diversity. Here, we investigate series of epidemiological demographic lifestyle 1387 men recruited part multi-ethnic Southern Cancer Study (SAPCS). We found poverty be decisive factor disease grade age diagnosis, other notably PCa...
Previously, we developed and applied a glasshouse screen for potato tuber yield under heat stress identified candidate gene (HSc70) tolerance by genetic analysis of diploid population. Specific allelic variants were expressed at high levels on exposure to moderately elevated temperature due variations in promoter sequence. In this study, aimed confirm the results from field trials conducted over several seasons locations including those Kenya, Malawi UK. We extend our understanding HSc70...
Abstract African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common variants contributing to multiethnic polygenic score, with rare focused on panel roughly 20 pathogenic genes. Based this knowledge, we were unable determine or differentiate status interrogating whole genome data 113 Black South men. To further assess potentially functional variant...
● GERMIN3 has previously been identified as a target of the tuberigen activation complex suggesting function in potato tuberisation but its role is presently unknown. To understand we analysed morphological, agronomic and molecular phenotypes transgenic lines. over-expressing lines Solanum tuberosum ssp. andigena exhibited increased tuber yields under permissive conditions enhanced numbers. Post-harvest sprouting reduced apical dominance with numbers sprouts. Apical was aerial tissues mature...
Abstract Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such exclude for ancestral diversity. Here, we investigate series of epidemiological demographic lifestyle 1,387 men recruited part multi-ethnic Southern Cancer Study (SAPCS). We found poverty be decisive factor disease grade age diagnosis, other notably...
Prior to 1915, an organization known as the Pacific Slope Association of Economic Entomologists had existed for some years on west coast. Desiring expand their activities, they consulted with American about consolidation. As a result, special meeting A.A.E.E. and was held in Berkeley August 1915. After discussion resolution drawn up recommending that P.S.A. be accepted branch A.A.E.E., Branch. This recommendation by at its regular Columbus, Ohio, December 1915; thus first our society formed.
Abstract Prostate cancer is characterised by significant global disparity; mortality rates in Sub-Saharan Africa are double to quadruple those Eurasia 1 . Hypothesising unknown interplay between genetic and non-genetic factors, tumour genome profiling envisages contributing mutational processes 2,3 Through whole-genome sequencing of treatment-naïve prostate from 183 ethnically/globally distinct patients (African versus European), we generate the largest genomics resource for Africa....