A5041707665- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Ocular and Foreign Body Injuries
- Ocular Infections and Treatments
- Photoreceptor and optogenetics research
- Drug-Induced Ocular Toxicity
- Neonatal Respiratory Health Research
- Ocular Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Ocular Oncology and Treatments
- Vascular Malformations Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Genetic Syndromes and Imprinting
- Paraoxonase enzyme and polymorphisms
- Systemic Lupus Erythematosus Research
- Ocular and Laser Science Research
- Ophthalmology and Visual Impairment Studies
- Hedgehog Signaling Pathway Studies
Sankara Nethralaya
2015-2024
Medical Research Foundation
1970-2024
Dr. Agarwal's Eye Hospital
2024
Creative Commons
2021-2023
Elite School of Optometry
2022
Tanta University
2022
Dr. M.G.R. Educational and Research Institute
2022
India Diabetes Research Foundation
2017-2020
Chaithanya Eye Hospital and Research Institute
2018
To evaluate structural changes in the choroid among patients with diabetic macular edema (DME), varying grades of retinopathy (DR), using enhance depth imaging spectral domain optical coherence tomography (EDI SD-OCT) scans.A cross-sectional study was conducted on 82 eyes DR and DME 86 healthy control eyes. Eyes were classified according to severity as per international scale. Sub foveal choroidal thickness (SFCT)was obtained EDI SD-OCT scans. These scans binarized into luminal stromal...
To report the efficacy of intravitreal voriconazole.Retrospective analysis an interventional case series five cases culture-proven fungal endophthalmitis treated with voriconazole was done. Only found to be resistant conventional antifungal agents were included in study. The diagnosis established on basis clinical as well microbiological examination. All patients received one or more injections voriconazole. Resolution determined infection and final visual acuity main outcome...
This study was undertaken to evaluate the prevalence of idiopathic macular hole in a defined community Southern India.In all, 7774 9546 enumerated (81.43%) subjects availed themselves for an ophthalmic assessment which included detailed examination and fundus photography. All data were entered stored secure computerized database statistical analysis performed using spss Windows.Thirteen comprising six males seven females diagnosed with holes equating risk 0.17%. Bilateral found two subjects....
The study was undertaken to evaluate the prevalence of retinitis pigmentosa (RP) in rural and urban South India.Seven thousand seven hundred seventy four subjects aged 40 years or more from Tamil Nadu, underwent comprehensive ophthalmic examination out 9576 enumerated (81.17%). After a thorough examination, fundus photographs were taken for documentation. Statistical analysis done using SPSS Windows (ver 14).7461 (95.9%) had details seen both eyes. Thirteen (0.17%; 4 males, 9 females)...
Complement factor H shows very strong association with Age-related Macular Degeneration (AMD), and recent data suggest that multiple causal variants are associated disease. To refine the location of disease variants, we characterized in detail structural variation at CFH its paralogs, including two copy number polymorphisms (CNP), CNP147 CNP148, several rare deletions duplications. Examination 34 AMD-enriched extended families (N = 293) AMD cases (White N 4210 Indian 134; Malay 140) controls...
The aim was to investigate the effect of axial length on full-field electroretinogram (ffERG) and multifocal (mfERG) in young Indian subjects.One hundred subjects (44 male) with refractive errors from +0.50 -18.00 DS no myopic retinopathy underwent measurement. ffERG measured, which included scotopic photopic responses according International Society for Clinical Electrophysiology Vision (ISCEV) guidelines. mfERG recorded after correcting error ISCEV standards. dark-adapted light-adapted...
Age-related Macular Degeneration (AMD) is one of the major vision-threatening diseases eye. Oxidative stress key factors in onset and progression AMD. In this study, metabolites associated with AMD pathology more so at systemic level namely, oxidized LDL (oxLDL), homocysteine (Hcy), thiolactone (HCTL), advanced glycation end product (AGE) were evaluated for their pro-oxidant nature a localized ocular environment based on vitro studies human retinal pigment epithelial cells (ARPE-19 cells)....
Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP) are retinal degenerative diseases which cause severe dystrophy affecting the photoreceptors. LCA is predominantly inherited as an autosomal recessive trait contributes to 5% of all dystrophies; whereas RP by Mendelian pattern inheritance both leading causes visual impairment in children young adults. Homozygosity mapping efficient strategy for known novel disease loci conditions, especially a consanguineous mating, exploiting...
Bardet-Biedl syndrome (BBS), a ciliopathy disorder with pleiotropic effect manifests primarily as retinal degeneration along renal insufficiency, polydactyly and obesity. In this study, we have performed homozygosity mapping using NspI 250K affymetrix gene chip followed by mutation screening of the candidate genes located in homozygous blocks. These regions are prioritized based on block length candidature BBS other ciliopathies. Gene alterations known (22) such ALMS1 (2) were seen 24 30...
Aim: To describe the clinical features, treatment and outcome patterns in 307 eyes with Coats' disease. Materials Methods: Retrospective chart review of patients diagnosed disease between January 1996 2006 from a single referral center southern India. Results: Two hundred eighty (307 eyes) mean age 15.67 years (range: Four months-80 years) were included. Decreased vision (77%), unilateral affection (90%) male preponderance (83.4%) chief presenting features. Anterior segment involvement was...
Congenital stationary night blindness (CSNB) is an inherited retinal disease that often associated with high myopia and can be caused by pathological variants in multiple genes, most commonly
Aim: An analysis of late in-the-bag dislocation intraocular lenses (IOL), in uveitic eyes. Setting: Referral uveitis clinic. Design: Retrospective case series. Materials and Methods: All records eyes with chronic that had phacoemulsification IOL implantation, at a referral clinic between February 1997 January 2015 were retrieved analyzed. Only those no documented intraoperative complication predisposing risks to dislocation, such as pseudoexfoliation, high myopia, trauma, prior VR surgery...
To describe the clinical pattern of uveitis in patients with retinitis pigmentosa (RP) at a tertiary care eye hospital over period 30 years.The medical records 32 eyes 22 RP were included this study. Collected data age, subsets uveitis, best corrected visual acuities (BCVA), detailed laboratory investigations, and treatment.Mean age presentation was 53.4 ± 18.8 years, mean diagnosis 39.2 21.4 years. Uveitis bilateral 10 (45.5%) patients. The most common current study anterior (56.2%),...
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous autosomal recessive disorder characterized by multiple organ defects involving retina, kidney, liver and brain. Disease-causing mutations in BBS genes narrowed down homozygosity mapping small consanguineous non-consanguineous pedigrees were reported 80 per cent of the study population. This was aimed to screen these (BBS3, BBS10) specific exons (BBS1, BBS5, MKKS, BBS9, BBS11 BBS12) for recurrent selected sample patients.The screened...