A5031684066- Gut microbiota and health
- Veterinary Medicine and Surgery
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Urological Disorders and Treatments
- Probiotics and Fermented Foods
- Veterinary Equine Medical Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Mollusks and Parasites Studies
- Neonatal Health and Biochemistry
- Foreign Body Medical Cases
- Hemostasis and retained surgical items
- Methemoglobinemia and Tumor Lysis Syndrome
- Diabetes and associated disorders
- Congenital Anomalies and Fetal Surgery
- Cardiovascular Conditions and Treatments
- Veterinary Orthopedics and Neurology
- Circular RNAs in diseases
- Congenital Heart Disease Studies
- Pancreatitis Pathology and Treatment
- Neurogenetic and Muscular Disorders Research
- Dietary Effects on Health
- Epigenetics and DNA Methylation
University of Copenhagen
2015-2024
Abstract Obese dogs seem to have a different gut microbiome ( GM ) composition compared lean dogs, and in humans, may negatively impact the ability lose weight some individuals. The purpose of this study was investigate interaction between exercise, weight‐loss dogs. Eighteen obese pet were recruited for 12‐week intervention. All fed restrictively with commercial high‐protein/high‐fibre dry diet, eight these enrolled an exercise program addition diet Faecal samples collected weighed at week...
Obesity and inactivity are major risk factors of feline diabetes mellitus (FDM) human type II (T2DM). In recent years, changes in the gut microbiota have been suggested as a contributing factor to T2DM. Whether (GM) composition plays role FDM remains unknown. The aim current study was firstly cross-sectional comparison GM diabetic cats, that lean, obese/overweight non-diabetic cats similar age. Specifically, fecal samples from 82 privately-owned Denmark Switzerland were sequenced using 16S...
Compared with lean humans, the gut microbiota is altered in obese. Whether these changes are due to an obesogenic diet, and whether contributes adiposity currently discussed. In cat population, where obesity also prevalent, microbiome associated have not been studied. Consequently, aim of this study was compare cats, that overweight obese cats. Seventy-seven rescue-shelter cats housed for ≥3 consecutive days were included study. Faecal samples obtained by rectal swab and, when available, a...
Genome wide association studies (GWAS) have been utilized to identify genetic risk loci associated with both simple and complex inherited disorders. Here, we performed a GWAS in Labrador retrievers hip dysplasia body weight. Hip scores were available for 209 genotyped dogs. We identified significantly locus on chromosome 24, three equally SNPs (p = 4.3 × 10
Aminopenicillins with or without a β-lactamase inhibitor are widely used in both human and veterinary medicine. However, little is known about their differential impact on the gut microbiota development of antimicrobial resistance.To investigate changes faecal dogs treated amoxicillin amoxicillin/clavulanic acid.Faeces collected from 42 (21 per treatment group) immediately before, during 1 week after termination oral acid were analysed by culture 16S rRNA gene sequence analysis.In groups,...
Background Symmetric dimethylarginine ( SDMA ) has been increasingly used as a marker of early chronic kidney disease CKD in cats, but little is known about the influence comorbidities on this species. Hypothesis Hypertrophic cardiomyopathy HCM and diabetes mellitus DM ), independently , are associated with changes serum . Animals Ninety‐four cats (17 40 17 20 healthy controls). Methods Case‐control study. Clinical examination, echocardiography, ECG blood pressure, CBC biochemistry,...
Objectives Subclinical bacteriuria (SBU) is the presence of bacteria in urine with no clinical evidence lower urinary tract disease. The aims this study were to investigate if being overweight and/or obesity predispose cats SBU, previously reported risk factors and determine prevalence SBU a prospectively sampled cohort middle-aged elderly cats. Methods Cats aged ⩾6 years presenting University Hospital for Companion Animals Copenhagen from 2015–2019 causes unrelated eligible enrolment. Body...
Objectives Bleeding diathesis is a complication in dogs infected with Angiostrongylus vasorum . This retrospective study investigated clinical and laboratory haemostatic differences A. ‐positive without signs of bleeding impact on survival. Materials Methods Demographics, type bleeding, haematocrit range tests, including thromboelastography derived velocity curves were retrospectively registered from dogs. All parameters compared between using univariable analyses. Binomial multinomial...
In dogs, the use of probiotics for preventive or therapeutic purposes has become increasingly common, however evidence beneficial effects are often limited. The aim this study was to investigate feeding a diet containing Enterococcus faecium NCIMB 10415 on faecal quality, short-chain fatty acid concentrations, serum concentrations cholesterol, triglycerides, cobalamin and folate as well microbiome in adult dogs. Eleven healthy client owned dogs were enrolled randomized, double-blinded...
Abstract Background Specific biomarkers of pyelonephritis (PN) in cats are lacking. MicroRNAs (miRNAs) have diagnostic potential human nephropathies. Objectives To investigate the presence/stability miRNAs whole urine and discriminatory selected urinary for PN cats. Animals Twelve healthy cats, 5 with PN, 13 chronic kidney disease (n = 5), subclinical bacteriuria 3), ureteral obstructions 5) recruited from 2 companion animal hospitals. Methods Prospective case‐control study. Expression...
Acquired canine proximal renal tubulopathy (Fanconi syndrome) related to excessive ingestion of jerky treats has been recognized since 2007. This study aimed improve knowledge about the syndrome’s characteristics, especially long-term outcome. By reaching out veterinarians and dog owners, dogs suspected induced Fanconi syndrome were identified. The dog’s medical records reviewed, owners interviewed. Data was analyzed using linear mixed models (p < 0.05 considered statistically significant)...
Abstract Background Obesity is a risk factor for diabetes mellitus, which commonly coexists with pancreatitis in cats. However, obesity has not previously been associated Objectives To evaluate factors affecting serum concentrations of pancreatic lipase immunoreactivity (fPLI), trypsin‐like (fTLI), cobalamin and folate clinically healthy lean, overweight obese, or diabetic Animals Seventy‐nine client‐owned cats (27 lean [LN, BCS 4‐5/9], 30 obese [OW, 7‐9/9], 22 [DM]) were included. Methods...
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs have been found in urine and shown diagnostic potential human nephropathies. Here, we aimed to characterize, for first time, feline urinary miRNAome explore use of miRNA profiles as non-invasive biomarkers pyelonephritis (PN). Thirty-eight cats were included a prospective case-control study classified five groups: healthy Control (n = 11), with PN 10), subclinical bacteriuria...