A5017505763- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Plant Parasitism and Resistance
- Plant Stress Responses and Tolerance
- Adenosine and Purinergic Signaling
- Immune Cell Function and Interaction
- Plant Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Transgenic Plants and Applications
- Toxin Mechanisms and Immunotoxins
- Endoplasmic Reticulum Stress and Disease
- Plant Molecular Biology Research
- Legume Nitrogen Fixing Symbiosis
- Insect-Plant Interactions and Control
University of Tübingen
2019-2025
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2025
Université de Montpellier
2025
Centre Occitanie-Montpellier
2025
Institut de Recherche pour le Développement
2025
Institut Agro Montpellier
2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2025
Plant nucleotide-binding (NB) leucine-rich repeat (LRR) receptor (NLR) proteins function as intracellular immune receptors that perceive the presence of pathogen-derived virulence (effectors) to induce responses. The 2 major types plant NLRs "sense" pathogen effectors differ in their N-terminal domains: these are Toll/interleukin-1 resistance (TIR) domain-containing (TNLs) and coiled-coil (CC) (CNLs). In many angiosperms, RESISTANCE TO POWDERY MILDEW 8 (RPW8)-CC domain containing NLR (RNL)...
Summary Activation of nucleotide‐binding leucine‐rich repeat receptors (NLRs) results in immunity and a localized cell death. NLR death activity requires oligomerization some cases plasma membrane (PM) localization. The exact mechanisms underlying PM localization NLRs lacking predicted transmembrane domains or recognizable lipidation motifs remain elusive. We used confocal microscopy, genetically encoded molecular tools protein‐lipid overlay assays to determine whether members the...
ABSTRACT Plants utilize cell surface-localized pattern recognition receptors (PRRs) and intracellular nucleotide-binding leucine-rich repeat (NLR) to detect non-self elicit robust immune responses. Fine-tuning the homeostasis of these is critical prevent their hyperactivation. Here, we show that Arabidopsis plants lacking metacaspase 1 ( At MC1) display autoimmunity dependent on signalling components downstream NLR PRR activation. Overexpression a catalytically inactive MC1 in an atmc1...
The HD-ZIP III transcription factor REVOLUTA (REV) is involved in early leaf development, as well senescence. REV directly binds to the promoters of senescence-associated genes, including central regulator WRKY53. As this direct regulation appears be restricted senescence, we aimed characterize protein-interaction partners which could mediate senescence-specificity. interaction between and TIFY family member TIFY8 was confirmed by yeast two-hybrid assays, bimolecular fluorescence...
Abstract Plants use both cell surface and intracellular immune receptors with leucine rich-repeat (LRRs) to detect pathogens. LRR receptor kinases (LRR-RKs) receptor-like proteins (LRR-RPs) recognize extracellular microbe-derived molecules confer pattern-triggered immunity (PTI), while nucleotide-binding (NLR) microbial effectors inside the effector-triggered (ETI). Despite PTI ETI signaling being initiated in different compartments, rely on transcriptional activation of similar sets genes,...
Plants evolved a sophisticated, receptor-based, innate immune system.Cell surface localized pattern recognition (PRR) and intracellular nucleotide-binding leucine-rich repeat (NLR) receptors detect pathogen-associated molecular patterns or pathogen-derived effector molecules, respectively, induce range of common responses.These include Ca 2+ fluxes, reactive oxygen species production, mitogen-activated protein kinase activation [1].Recent studies have demonstrated an interdependency mutual...
Abstract The BRI1-associated kinase BAK1/SERK3 is a positive regulator of multiple leucine rich receptor kinase-mediated signaling pathways including pattern triggered immunity (PTI). Absence or overexpression BAK1 leads to spontaneous cell death formation. BAK1-interacting receptors (BIR) constitutively interact with BAK1, and plants lacking overexpressing BIR proteins phenocopy the symptoms observed in bak1 knock outs overexpressors. In interactome BIR3, TIR-NBS-LRR protein CONSTITUTIVE...
Abstract Activation of intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) results in immunity and a localized cell death response infected cells. Cell activity many NLRs requires oligomerization some cases plasma membrane (PM) localization. However, the exact mechanisms underlying PM localization lacking recognizable N- or C-terminal lipidation motifs predicted transmembrane domains remains elusive. Here we show that stability members RPW8-like coiled-coil (CC R ) domain...