A5024770850- SARS-CoV-2 and COVID-19 Research
- Mitochondrial Function and Pathology
- Photosynthetic Processes and Mechanisms
- vaccines and immunoinformatics approaches
- ATP Synthase and ATPases Research
- Peptidase Inhibition and Analysis
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Animal health and immunology
- Viral Infections and Outbreaks Research
- Algal biology and biofuel production
- Microbial Community Ecology and Physiology
- Cardiomyopathy and Myosin Studies
- Animal Virus Infections Studies
- Autophagy in Disease and Therapy
- Alcohol Consumption and Health Effects
- Viral Infectious Diseases and Gene Expression in Insects
- interferon and immune responses
- Respiratory viral infections research
- bioluminescence and chemiluminescence research
- Legume Nitrogen Fixing Symbiosis
- Computational Drug Discovery Methods
- Microbial Metabolism and Applications
- Ubiquitin and proteasome pathways
- Bacillus and Francisella bacterial research
Stanford University
2020-2024
University of New Orleans
2019-2021
Abstract Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain-like protease (PLpro) domain of Nsp3 from SARS-CoV-2 essential for viral replication. In addition, PLpro dysregulates the host immune response cleaving ubiquitin and interferon-stimulated gene 15 protein proteins. As a result, promising target inhibition small-molecule therapeutics. Here we design series...
The large cytosolic GTPase, dynamin-related protein 1 (Drp1), mediates both physiological and pathological mitochondrial fission. Cell stress triggers Drp1 binding to Fis1 subsequently, fragmentation, ROS production, metabolic collapse, cell death. Because also fission by Mff, therapeutics that inhibit should spare P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models neurodegeneration, ischemia, sepsis without blocking the functions Drp1. Since peptides...
The common aldehyde dehydrogenase 2 ( ALDH2 ) alcohol flushing variant known as ALDH2*2 affects ∼8% of the world’s population. Even in heterozygous carriers, this missense leads to a severe loss enzymatic activity and has been linked an increased risk coronary artery disease (CAD). Endothelial cell (EC) dysfunction plays determining role all stages CAD pathogenesis, including early-onset CAD. However, contribution EC its relation are not fully understood. In large genome-wide association...
COVID-19 emergency use authorizations and approvals for vaccines were achieved in record time. However, there remains a need to develop additional safe, effective, easy-to-produce, inexpensive prevention reduce the risk of acquiring SARS-CoV-2 infection. This is due difficulties vaccine manufacturing distribution, hesitancy, and, critically, increased prevalence variants with greater contagiousness or reduced sensitivity immunity. Antibodies from eggs hens (immunoglobulin Y; IgY) that...
Significance Marine phytoplankton are responsible for nearly half of the primary productivity on Earth, and picocyanobacterium Synechococcus contributes up to 16% this total. strains optimize their fitness by using different chromophores photosynthetic light-harvesting in light color niches. Many use chromatic acclimation adjust chromophore composition ambient blue green ratios. We determined that interplay between two attachment enzymes, MpeY MpeZ, plays a role at level gene expression. The...
Significance Of all cyanobacteria on Earth, marine Synechococcus are those displaying the greatest pigment diversity. The most sophisticated type is cells able to reversibly modify their color by a phenomenon called IV chromatic acclimation or CA4. Two genetically distinct CA4 types (CA4-A and CA4-B) have evolved in different lineages. Together, they represent almost half of oceanic areas equally abundant but occupy complementary ecological niches. While molecular mechanism CA4-A has...
In December 2019, a novel coronavirus, termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of pneumonia with distress and outbreaks in Wuhan, China. The rapid global spread SARS-CoV-2 resulted 2019 (COVID-19) pandemic. Earlier during pandemic, there were limited genetic viral variations. As millions people became infected, multiple single amino acid substitutions emerged. Many these have no consequences. However, some new variants show greater...
A mutation analysis of SARS-CoV-2 genomes collected around the world sorted by sequence, date, geographic location, and species has revealed a large number variants from initial reference sequence in Wuhan. This also reveals that humans infected with have mink populations Netherlands, Denmark, United States, Canada. In these animals, small set mutations spike protein receptor binding domain (RBD), often occurring specific combinations, transferred back into humans. The viral genomic minks...
Two SARS-CoV-2 variants of concern showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant appears cause more severe illness nor risk death, faster spread is a major threat. Using computational tools, we found that new may acquire an by increasing propensity its spike protein expose receptor binding domain via proteolysis, perhaps neutrophil elastase and/or reduced intramolecular interactions contribute stability closed...
Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain-like protease (PLpro) domain of Nsp3 from SARS-CoV-2 essential for viral replication. In addition, PLpro dysregulates the host immune response cleaving ubiquitin and interferon-stimulated gene 15 protein (ISG15) proteins. As a result, promising target inhibition small-molecule therapeutics. Here we have designed series...
Abstract Cardiac troponin I (cTnI) is a sarcomeric protein critical to myocyte contraction. Unexpectedly, we found that some cTnI localized the mitochondrial matrix in heart, inhibited functions when stably expressed non-cardiac cells and increased opening of permeability transition pore under oxidative stress. Direct, specific, saturable binding ATP synthase was demonstrated vitro , using immune-captured synthase, proximity ligation assay. doubled F 1 0 ATPase activity, whereas skeletal...
ABSTRACT COVID-19 emergency use authorizations and approvals for vaccines were achieved in record time. However, there remains a need to develop additional safe, effective, easy-to-produce, inexpensive prevention reduce the risk of acquiring SARS-CoV-2 infection. This is due difficulties vaccine manufacturing distribution, hesitancy, and, critically, increased prevalence variants with greater contagiousness or reduced sensitivity immunity. Antibodies from eggs hens (immunoglobulin Y; IgY)...
Introduction: Anemia is one of the common medical conditions prevalent in our society. The correct categorization varying types anemia essential for therapeutic purposes. Various laboratory tests are done to find out its underlying cause, but peripheral smear (PS) study red blood cells (RBCs) morphology important along with cell indices classification anemia.
 Objectives: This was evaluate RBC on examination patients and compare these findings counter generated comprising Mean...
Abstract In December 2019, a novel coronavirus, termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of pneumonia with distress and outbreaks in Wuhan, China. The rapid global spread SARS-CoV-2 resulted 2019 (COVID-19) pandemic. Earlier during pandemic, there were limited genetic viral variations. As millions people became infected, multiple single amino acid substitutions emerged. Many these have no consequences. However, some new variants show...
Abstract A mutation analysis of SARS-CoV-2 genomes collected around the world sorted by sequence, date, geographic location, and species has revealed a large number variants from initial reference sequence in Wuhan. This also reveals that humans infected with have mink populations Netherlands, Denmark, United States, Canada. In these animals, small set mutations spike protein receptor binding domain (RBD), often occurring specific combinations, transferred back into humans. The viral genomic...
Abstract Two SARS-CoV-2 variants showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant causes more severe illness or risk of death, faster spread is a major threat. Using computational tools, we found that new may acquire an by increasing propensity its spike protein expose receptor binding domain. This information leads identification potential treatments avert imminent threat these transmittable variants. Teaser The infective...
The heart relies on mitochondria for its extensive energetic demands, and some cytoskeletal elements can regulate mitochondrial function. Cardiac troponin I (cTnI) is a structural protein involved in sarcomeric contraction. Here we demonstrate that cTnI localizes to mitochondria, inhibits functions, increases opening of the permeability transition pore under oxidative stress. Purified directly binds immune-captured ATP synthase saturable fashion doubles "reverse" F 1 0 -ATPase activity vitro...
Abstract Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain-like protease (PLpro) domain of Nsp3 from SARS-CoV-2 essential for viral replication. In addition, PLpro dysregulates the host immune response cleaving ubiquitin and interferon-stimulated gene 15 protein (ISG15) proteins. As a result, promising target inhibition small-molecule therapeutics. Here we have...