A5007717855- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Enzyme Catalysis and Immobilization
- Protease and Inhibitor Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Phytochemical compounds biological activities
- Angiogenesis and VEGF in Cancer
- Marine Sponges and Natural Products
- Urticaria and Related Conditions
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Bioactive Compounds
- Gout, Hyperuricemia, Uric Acid
- Pharmacology and Obesity Treatment
- Glaucoma and retinal disorders
- Invertebrate Immune Response Mechanisms
- Enzyme Production and Characterization
- Peptidase Inhibition and Analysis
- Phytochemical Studies and Bioactivities
- Bone Metabolism and Diseases
- Pharmacogenetics and Drug Metabolism
- Bone and Dental Protein Studies
- Neurological Disease Mechanisms and Treatments
China Pharmaceutical University
2012-2022
Harbin University of Commerce
2015-2022
Jilin University
2010-2021
First Hospital of Jilin University
2010-2021
Division of Undergraduate Education
2015
Shandong University
2008-2010
High‑mobility group box 1 (HMGB1) is released after focal cerebral ischemia/reperfusion (I/R), and aggravates brain tissue damage. Ginsenoside Rb1 (Rb1), isolated from Panax ginseng, has been reported to inhibit I/R‑induced cell death in the brain. The present study aimed investigate protective ability of GRb1 on I/R rats explore its further mechanisms. A middle artery occlusion (MCAO) rat model was established treated with different doses Rb1. neurological deficits were examined...
Chinese herbal medicine is widely used because it has a good safety profile and few side effects. However, the risk of adverse drug reactions caused by herb-drug interactions (HDIs) often overlooked. Therefore, task identifying possible HDIs elucidating their mechanisms great significance for prevention treatment HDI-related reactions. Since extract from Dioscorea bulbifera L. rhizomes (DB) can cause various degrees liver damage, speculated that may occur between DB chemicals metabolized or...
Matrix metalloproteinase (MMP)-2 and MMP-9 have been associated with the ability of tumor cells to metastasize because their capacity degrade type IV collagen, main component basement membrane, elevated expression in malignant tumors. (S)-methyl 6-(benzyloxycarbonylamino)-2-(2-((S)-2,6-dioxo-3-(3,4,5-trimethoxybenzamido) piperidin-1-yl) acetamido) hexanoate (CH1104I) is a galloyl cyclic-imide derivative designed fit extend into S1′ active pocket MMP-2 MMP-9. We aimed evaluate efficacy...
To investigate the constituents of Annona squamosa and evaluate their anti-tumor activity.The compounds were isolated purified by various column chromatography. Their structures elucidated spectral data analysis. activity was assayed SRB method.Eleven obtained from 95% EtOH extract. The determined as: annosquamosin C(1),15, 16-epoxy-17-hydroxy-ent-kau-ran-19-oic acid (2),16,17-dihydroxy-ent-kau-ran-19-oic acid(3), A(4), ent-kaur-16-en-19-oic (5), 19-nor-ent-kauran4-ol-17-oic (6),16-hydroxy...
Abstract Three new ent ‐kaurane diterpenoids, (4 α )‐19‐nor‐ ‐kaurane‐4,16,17‐triol ( 1 ), ,16 )‐17‐(acetyloxy)‐19‐nor‐ ‐kaurane‐4,16 ‐ diol 2 and 17‐hydroxy‐ ‐kaur‐15‐en‐19‐al 3 together with 11 known compounds, were isolated from the stem bark of Annona squamosa L. The structures – identified by analysis their spectroscopic data. All compounds evaluated for cytotoxic activity against human lung cancer (95‐D) ovarian (A2780) cell lines, 3, 5, 7, 14 exhibited promising antiproliferative...
Clomiphene citrate is used to cause ovulation in females and increase semen production males. well tolerated most patients rarely induces liver injury. We report a case of injury which associated with administration clomiphene male patient.A 31-year-old man who was treated by for 5 days transferred our emergency room reddish-brown urine upper abdominal pain. The levels aspartate aminotransferase (AST) alanine (ALT) were elevated. Based on the subsequent examination, he diagnosed...
Naproxen is one of common non-steroidal antiinflammatory drugs (NS AIDs).Its pharmacological properties vary with different configurations.In order to improve the drug efficacy, it significant prepare high enantiopure drugs.In this study, carica papaya lipase (CPL) and papain extracted from crude enzyme are used for kinetic resolution recemic Naproxen.The types enzyme, influences reaction system, amount H 2 O were studied in obtain optimum conditions.The results showed that has ability over...
The soybean oil starch ester was synthesized by using Novozym435 lipase as biocatalyst, corn and substrate in solvent-free system.In order to improve the reaction activity of starch, pretreated NaOH/Urea/H2O solution.The optimum pretreatment conditions enzymatic esterification with were water activity<0.01,reaction temperature 60℃, time 30h, ratio 6 (w/w) amount 7%.Under this condition degree substitute 0.0302.The solubility, emulsifying freeze-thawing stability increased increase its...
A 35-year-old male patient received an IV infusion of flurbiprofen axetil 100 mg, which was diluted in ml 0.9% sodium chloride injection, once daily for waist and abdomen persistent colic because right ureteral calculi. The developed dyspnea, facial swelling, nasal obstruction, runny nose, laryngeal edema after the first dose about 20 minutes (infusion volume 50 ml). Flurbiprofen allergy considered. stopped immediately anti-allergy treatments with adrenaline, dexamethasone, budesonide,...