A5009675933- Microscopic Colitis
- Diverticular Disease and Complications
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Cellular Mechanics and Interactions
- Cardiomyopathy and Myosin Studies
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Hidradenitis Suppurativa and Treatments
- Congenital gastrointestinal and neural anomalies
- Celiac Disease Research and Management
- Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Mycobacterium research and diagnosis
- Reproductive tract infections research
- Diagnosis and treatment of tuberculosis
- Fungal and yeast genetics research
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Inflammatory mediators and NSAID effects
- Bariatric Surgery and Outcomes
- Esophageal and GI Pathology
Thomas Jefferson University
2019-2022
Massachusetts General Hospital
2016-2020
Harvard University
2016-2017
Brandeis University
2015-2016
St Mark's Hospital
2016
Adipose tissue in mesenteric fat plays a key role systemic and luminal inflammation. However, little is known about the of visceral adipose (VAT) its interaction with genetic predisposition Crohn's disease (CD) progression. Our study population included patients CD enrolled Prospective Registry Inflammatory Bowel Disease Study at Massachusetts General Hospital (PRISM). VAT volume was measured from computed tomography using Aquarius 3D. We used logistic regression models to estimate...
The critical role of the gut microbiome in microscopic colitis (MC) is evident by observation that fecal diversion associated with resolution mucosal inflammation while restoration stream recurrence disease.1 Characterization composition and function MC therefore could provide insights into disease pathogenesis.
The long-term natural history of microscopic colitis (MC) (collagenous (CC), lymphocytic (LC)), traditionally considered relapsing but non-progressive diseases, is poorly defined. Whether persistent histologic inflammation in such diseases associated with an increased risk colorectal neoplasia (CRN) or extracolonic cancers has not been robustly established. This retrospective cohort included diagnosed MC at a referral center. Rates CRN and cancer were compared to patients undergoing...
Introduction. Evidence has linked exogenous and endogenous sex hormones with the human microbiome.Hypothesis/Gap statement. The longitudinal effects of oral contraceptives (OC) on gut microbiome have not previously been studied.Aim. We sought to examine impact OC use taxonomic composition metabolic functions microbiota steroid after initiation use.Methodology. recruited ten healthy women who provided blood stool samples prior use, 1 month 6 months starting OC. measured serum levels hormones,...
The patterning of actin cytoskeleton structures in vivo is a product spatially and temporally regulated polymer assembly balanced by disassembly. While recent years our understanding mechanisms has grown immensely, knowledge disassembly machinery remained comparatively sparse. Saccharomyces cerevisiae an ideal system to tackle this problem, both because its amenabilities genetic manipulation live‐cell imaging only single gene encodes each the core factors: cofilin ( COF1 ), Srv2/CAP SRV2...
Previous studies of the relationship between dietary factors and risk diverticulosis have yielded inconsistent results. We therefore sought to investigate association consumption fruit vegetables prevalent diverticulosis.Our study population included participants in Gastrointestinal Disease Endoscopy Registry (GIDER), a colonoscopy-based longitudinal cohort at Massachusetts General Hospital, who provided comprehensive information on intake lifestyle using validated questionnaires prior...
period of 34.6 months (8-116 months).Predictors postoperative recurrence in univariate analysis were lack post-operative smoking cessation, the inaugural complications, ileal location, an interval between diagnosis and surgery < 9.5 months, healthy resection margins 2 cm.In a multivariate study, independent factors absence cm.Conclusions: The clinical is common after ileocecal Crohn's disease.Tobacco use, early surgery, cm predictive recurrence.
Abstract Weight loss through lifestyle modification is currently the standard of care in management patients with nonalcoholic fatty liver disease (NAFLD); however, benefits specific strategies for achieving weight these are poorly understood. We sought to determine whether patient satisfaction and health‐related quality life (HRQoL) vary by method NAFLD. Patients diagnosed NAFLD previous 6 months 3 years were identified chart review at our urban, tertiary medical center. Participants...
Abstract Background: Previous studies of the relationship between dietary factors and risk diverticulosis have yielded inconsistent results. We therefore sought to investigate association consumption fruit vegetables prevalent diverticulosis. Methods: Our study population included participants in Gastrointestinal Disease Endoscopy Registry (GIDER), a colonoscopy-based longitudinal cohort at Massachusetts General Hospital, who provided comprehensive information on intake lifestyle using...
Abstract Background: Previous studies of the relationship between dietary factors and risk diverticulosis have yielded inconsistent results. We therefore sought to investigate association consumption fruit vegetables prevalent diverticulosis. Methods: Our study population included participants in Gastrointestinal Disease Endoscopy Registry (GIDER), a colonoscopy-based longitudinal cohort at Massachusetts General Hospital, who provided comprehensive information on intake lifestyle using...
period of 34.6 months (8-116 months).Predictors postoperative recurrence in univariate analysis were lack post-operative smoking cessation, the inaugural complications, ileal location, an interval between diagnosis and surgery < 9.5 months, healthy resection margins 2 cm.In a multivariate study, independent factors absence cm.Conclusions: The clinical is common after ileocecal Crohn's disease.Tobacco use, early surgery, cm predictive recurrence.
period of 34.6 months (8-116 months).Predictors postoperative recurrence in univariate analysis were lack post-operative smoking cessation, the inaugural complications, ileal location, an interval between diagnosis and surgery < 9.5 months, healthy resection margins 2 cm.In a multivariate study, independent factors absence cm.Conclusions: The clinical is common after ileocecal Crohn's disease.Tobacco use, early surgery, cm predictive recurrence.
of demographic and disease variables on the risk poor outcomes using Chi-square McNemar log-rank tests.Results: Included were 18 patients (13 female): 11 had CD 7 UC/indeterminate colitis.The median age at time surgery was 49, BMI before 47. Median to BS after diagnosis 6 years (range 4-41 years).61% underwent gastric lap band (6 CD, 5 UC), 11% sleeve gastrectomy (2 0 28% Roux-en-Y bypass (3 2 UC).After a follow-up period 1-16 years), phenotype did not change.Further, (39%) developed...