A5064007487- Zebrafish Biomedical Research Applications
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Neurobiology and Insect Physiology Research
- Cardiac Fibrosis and Remodeling
- Retinal Development and Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hippo pathway signaling and YAP/TAZ
- Drug Transport and Resistance Mechanisms
- Tissue Engineering and Regenerative Medicine
- Physiological and biochemical adaptations
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Fungal and yeast genetics research
- Birth, Development, and Health
- Sodium Intake and Health
- Diet and metabolism studies
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Developmental Biology and Gene Regulation
- Cardiovascular Disease and Adiposity
- 3D Printing in Biomedical Research
- Congenital Heart Disease Studies
- Neuropeptides and Animal Physiology
Max Delbrück Center
2020-2024
German Centre for Cardiovascular Research
2020-2024
Max Planck Institute for Heart and Lung Research
2014-2017
Goethe University Frankfurt
2010-2012
Universidad Católica de Santa Fe
2012
Mahidol University
2005
Animals constantly need to judge the valence of an object in their environment: is it potential food or a threat? The brain makes fundamental decisions on appropriate behavioral strategy by integrating external information from sensory organs and internal signals related physiological needs. For example, hungry animal may take more risks than satiated one when deciding approach avoid object. Using proteomic profiling approach, we identified Calmodulin-interacting peptide Pcp4a as key...
The autonomic nervous system plays a pivotal role in cardiac repair. Here, we describe the mechanistic underpinning of adrenergic signaling fibrotic and regenerative response heart to be dependent on immunomodulation. A pharmacological approach identified receptor alpha-1 as key regulator macrophage phenotypic diversification following myocardial damage zebrafish. Genetic manipulation single-cell transcriptomics showed that signals activation an "extracellular matrix remodeling"...
Cells can sacrifice their individuality by fusing, but the prevalence and significance of this process are poorly understood. To approach these questions, here we generate transgenic reporter lines in zebrafish to label specifically ablate fused cells. In addition skeletal muscle cells, reporters cardiomyocytes starting at an early developmental stage. Genetic mosaics generated cell transplantation show expressing both donor- host-derived transgenes, confirming occurrence fusion larval...
Stressful experiences early in life can increase the risk of cardiovascular diseases. However, it remains largely unknown how stress influences susceptibility to disease onset. Here, we show that exposure brain-processed disrupts myocardial growth by reducing cardiomyocyte mitotic activity. Activation glucocorticoid receptor (GR), primary response pathway, reduces numbers, trabecular formation, and leads contractile dysfunction developing myocardium. a physiological level GR signaling is...
Abstract Aims Dysregulated immune response contributes to inefficiency of treatment strategies control hypertension and reduce the risk end-organ damage. Uncovering pathways driving transition from onset hypertensive stimulus manifestation multi-organ dysfunction are much-needed insights for targeted therapy. Methods results To aid visualization cellular events orchestrating pathogenesis, we modelled cardiovascular remodelling in zebrafish. Zebrafish larvae exposed ion-poor environment...
The larval zebrafish has emerged as a very useful model organism to study the neuronal circuits controlling neuroendocrine and behavioral responses stress. This protocol describes how expose larvae hyperosmotic stress test whether candidate populations of neurons are activated or inhibited by stressor using relatively rapid immunofluorescence staining approach. approach takes advantage phosphorylation extracellular signal-regulated kinase (ERK) upon activation. For complete details on use...
Epicardial adipose tissue (eAT) is a metabolically active fat depot that has been associated with wide array of cardiac homeostatic functions and cardiometabolic diseases. A full understanding its diverse physiological pathological roles hindered by the dearth animal models. Here, we show, in heart an ectothermic teleost, zebrafish, existence localized underneath epicardium, originating from epicardium exhibiting molecular signature beige adipocytes. Moreover, subset adipocytes within this...
Hypertension-induced ventricular remodeling contributes significantly to the progression of heart failure (HF). The global increase in HF prevalence results heightened cardiovascular morbidity and mortality, yet treatment options remain limited. gut microbiota ferments indigestible dietary fibers, producing essential metabolites such as short-chain fatty acids (SCFAs), amino metabolites. We hypothesize that direct oral administration SCFAs modulates mucosal immune cells, thereby ameliorating...