A5083740731- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- CAR-T cell therapy research
- Protein Tyrosine Phosphatases
- Monoclonal and Polyclonal Antibodies Research
- Head and Neck Cancer Studies
- Dysphagia Assessment and Management
- vaccines and immunoinformatics approaches
- Ferroptosis and cancer prognosis
- Galectins and Cancer Biology
- Lymphoma Diagnosis and Treatment
- interferon and immune responses
- Voice and Speech Disorders
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Salivary Gland Tumors Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Parathyroid Disorders and Treatments
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Cleft Lip and Palate Research
- Cytokine Signaling Pathways and Interactions
Loma Linda University
2012-2024
Loma Linda University Medical Center
2012-2024
University of Pittsburgh
2003-2013
UPMC Hillman Cancer Center
2006-2013
Zero to Three
2010
University of Pittsburgh Medical Center
2006-2010
Eye and Ear Foundation
2006
Tumor antigen-specific monoclonal antibodies (mAb) block oncogenic signaling and induce Fcγ receptor (FcγR)-mediated cytotoxicity. However, the role of CD8(+) CTL FcγR in initiating innate adaptive immune responses mAb-treated human patients with cancer is still emerging.FcγRIIIa codon 158 polymorphism was correlated survival 107 cetuximab-treated head neck (HNC). Flow cytometry carried out to quantify EGF (EGFR)-specific T cells HNC. The effect cetuximab on natural killer (NK) cell,...
Analog peptides represent a promising tool to further optimize peptide-based vaccines in promoting the expansion of tumor antigen-specific cytotoxic T lymphocytes. Here, we report results pilot trial designed study immunogenicity analog peptide NY-ESO-1 157-165V combination with CpG 7909/PF3512676 and Montanide ISA 720 patients stage III/IV NY-ESO-1–expressing melanoma. Eight were immunized either (arm 1, 3 patients); 2, 2 or Montanide, CpG, 3, patients). Only arm developed rapid increase...
Abstract Purpose: Human leukocyte antigen (HLA) class I processing machinery (APM) component downregulation permits escape of malignant cells from recognition by cytotoxic T lymphocytes (CTL) and correlates with poor prognosis in patients head neck cancer (HNC). Activated STAT1 (pSTAT1) is necessary for APM expression HNC cells. We investigated whether an overexpressed phosphatase was responsible basal suppression pSTAT1 subsequent component-mediated immune Experimental Design:...
Abstract Objective: This study was designed to evaluate the oropharyngeal complications of suspension laryngoscopy (SL). Methods: We prospectively analyzed 56 consecutive SLs for intervention‐related complications. Oropharyngeal symptoms and physical examination abnormalities were recorded before after SL. SL‐related problems graded in severity followed over time (weekly) until resolution achieved. All patients had SL with either a gallows or manual technique not rotation‐oriented (fulcrum)...
Oral squamous cell carcinoma (OSCC) accounts for more than 90% of the malignant neoplasms that arise in mucosa upper aerodigestive tract. Recent studies cleft lip/palate have shown association genes involved cancer. WNT pathway been associated with several types cancer and recently lip/palate. To investigate if were also oral cancer, we genotyped 188 individuals OSCC 225 control markers AXIN2, AXIN1, GSK3β, WNT3A, WNT5A, WNT8A, WNT11, WNT3, WNT9B. Statistical analysis was performed PLINK...
The aim of this study, using a retrospective chart review as the primary study design, was to determine relative contribution clinicopathologic risk factors versus low- and high-risk grade histologic groups assist management parotid cancers.In all, 168 malignancies were treated surgically at tertiary care center from 1982 2005. Of these, 115 patients with complete follow-up information further analyzed. Pathologic updating reclassification in 28% cases enabled comparison tumor histology or...
Ability to cross-present exogenous antigens in the human leukocyte antigen class I pathway is key presenting function of mature tumor cell-loaded dendritic cells (DC). Conditions DC maturation have been shown be important for DCs ability produce proinflammatory cytokines and induce T cell effector functions. However, it remains unknown if different pathways are associated with modulation (TA). Here, we compare matured 3 clinically relevant cytokine combinations including interleukin (IL)-1...
Therapeutic targeting of the epidermal growth factor receptor (EGFR), which is highly overexpressed and correlated with poor prognosis in colorectal head neck squamous cell carcinoma (SCCHN), has shown clinical efficacy using blocking mAbs, cetuximab or panitumumab, but only 10% to 20% patients. Clinical responsiveness certain Fcgamma genotypes, suggesting immune activity may contribute therapeutic efficacy. In addition, cetuximab-resistant tumor cells exhibit ubiquitination degradation...
The MAGE antigens are frequently expressed cancer vaccine targets. However, quantitative analysis of expression in upper aerodigestive tract (UADT) tumor cells and its association with T-cell recognition has not been performed, hindering the selection appropriate candidates for MAGE-specific immunotherapy. Using RT-PCR (QRT-PCR), we evaluated MAGE-3/6 65 UADT cancers, 48 normal samples from matched sites 7 HLA-A*0201+ squamous cell carcinoma head neck (SCCHN) lines. Expression results were...
In head and neck squamous cell carcinoma (HNSCC), expression levels of the epidermal growth factor receptor (EGFR) correlate with poor prognosis decreased survival rates. As mechanisms responsible for cellular immune response to EGFR in vivo remain unclear, frequency function EGFR-specific cytotoxic T cells (CTL) was determined HNSCC patients. The CTL specific HLA-A2.1-restricted EGFR-derived YLN peptide (YLNTVQPTCV) KLF (KLFGTSGQKT) 16 HLA-A2.1+ patients healthy individuals (NC) by...
To determine whether advanced imaging is cost-effective compared to primary bilateral neck exploration in the management of non-localizing hyperparathyroidism.Cost-effectiveness analysis.Cost-effectiveness analysis based on decision tree model and available Medicare financial data using from 347 consecutive patients having parathyroidectomy for hyperparathyroidism with either 1) positive, concordant ultrasound sestamibi or 2) negative ultrasound.Bilateral (BNE) costs $9578 has a success rate...
Effects of the tumor microenvironment (TME) stromal cells on progression in thyroid cancer are largely unexplored. Elucidating effects and underlying mechanisms may facilitate development targeting therapy for aggressive cases this disease. In study, we investigated impact TME stem-like (CSCs) patient-relevant contexts where applying vitro assays xenograft models uncovered contributions to progression. We found that can enhance CSC self-renewal invasiveness mainly via phosphatidylinositol...
Abstract Background The purpose of this study was to evaluate our surgical experience in patients with primary hyperparathyroidism (PHPT) nonlocalizing sestimibi and ultrasound scans. Methods A retrospective review 521 treated from April 2005 July 2017 at Loma Linda University Medical Center who received parathyroidectomy for PHPT. One hundred forty‐seven (28%) had double negative localization (nonlocalizing sestamibi ultrasound). Results Surgical cure PHPT 97.3% 99.2% nonlocalized localized...
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Solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is a rare, slow growing vascular tumor. In the head and neck region, it usually seen in nasal or oral cavity, orbit, jaw, parotid region. It has equal male to female distribution affects mainly younger adults with median age of 45 years. According World Health Organization, sometimes impossible distinguish HPC from SFT consequently, they are now classified as same entity. The first line treatment for this complete surgical removal wide...
Black Americans (BAs) with head and neck cancer (HNC) have worse survival outcomes compared to the White patients. While HNC disparities in patient for BAs been well recognized, specific drivers of inferior remain poorly understood. Here, we investigated biologic features tumor specimens obtained during surgical treatment oral cancers performed a follow-up study patients' post-surgery recurrences metastases aim explore whether could be associated poorer among BA patients American (WA) We...
<p>PDF file - 44K, SHP2 depletion does not upregulate pSTAT3</p>
<p>PDF file - 152K, SHP1 is not overexpressed in HNC tissue comparison to normal mucosa</p>