A5015481663- Venomous Animal Envenomation and Studies
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Pharmacological Effects of Natural Compounds
- Alcohol Consumption and Health Effects
- Healthcare and Venom Research
- Biochemical effects in animals
- Toxin Mechanisms and Immunotoxins
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Ion Channels and Receptors
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plants and Neuroprotection
- Biochemical and Structural Characterization
- Bioactive Compounds and Antitumor Agents
Instituto Butantan
2019-2024
Multiple sclerosis (MS) is a demyelinating disease of inflammatory and autoimmune origin, which induces sensory progressive motor impairments, including pain. Cells the immune system actively participate in pathogenesis progression MS by inducing neuroinflammation, tissue damage, demyelination. Crotalphine (CRO), structural analogue to peptide firstly identified Crotalus durissus terrificus snake venom, analgesia endogenous opioid release type 2 cannabinoid receptor (CB2) activation. Since...
Protein kinase Cε (PKCε) is highly expressed in nociceptor neurons and its activation has been reported as pro-nociceptive. Intriguingly, we previously demonstrated that of the mitochondrial PKCε substrate aldehyde dehydrogenase-2 (ALDH2) results anti-nociceptive effects. ALDH2 a major enzyme responsible for clearance 4-hydroxy-2-nonenal (4-HNE), an oxidative stress byproduct accumulated inflammatory conditions sufficient to induce pain hypersensitivity rodents. Here determined contribution...