A5059747713- Vector-borne infectious diseases
- Insect and Pesticide Research
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Vector-Borne Animal Diseases
- Dermatological diseases and infestations
- Toxin Mechanisms and Immunotoxins
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Viral Infections and Vectors
Czech Academy of Sciences, Biology Centre
2020-2024
Czech Academy of Sciences
2024
Institute of Parasitology
2020-2023
University of South Bohemia in České Budějovice
2018-2023
In addition to being vectors of pathogenic bacteria, ticks also harbor intracellular bacteria that associate with over generations, aka symbionts. The biological significance such bacterial symbiosis has been described in several tick species but its function Ixodes ricinus is not understood. We have previously shown I. are primarily inhabited by a single symbiont, Midichloria mitochondrii, an bacterium resides and reproduces mainly the mitochondria ovaries fully engorged females. To study...
During feeding on vertebrate hosts, ticks secrete saliva composed of a rich cocktail bioactive molecules modulating host immune responses. Although most the proteinaceous fraction tick is little immunogenicity, repeated mammalian hosts may lead to impairment feeding, preventing full engorgement. Here, we challenged rabbits with both Ixodes ricinus nymphs and adults observed formation specific antibodies against several salivary proteins. Repeated I. stages led gradual decrease in engorged...
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Ticks, notorious blood-feeders and disease-vectors, have lost a part of their genetic complement encoding haem biosynthetic enzymes are, therefore, dependent on the acquisition distribution host haem. Solute carrier protein SLC48A1, aka haem-responsive gene 1 (HRG1), has been implicated in transport, regulating availability intracellular HRG1 transporter identified both free-living parasitic organisms ranging from unicellular kinetoplastids, nematodes, up to vertebrates. However, an...
Genomes of ticks display reductions, to various extents, in genetic coding for enzymes the haem biosynthetic pathway. Here, we mined available transcriptomes soft tick species and identified transcripts encoding only half involved biosynthesis. Transcripts across most examined were those porphobilinogen synthase, coproporphyrinogen oxidase, protoporphyrinogen ferrochelatase. Genomic retention synthase seems be tick-restricted as no such homologue has been any hard species. Bioinformatic...