A5072481531- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Proteoglycans and glycosaminoglycans research
- HIV/AIDS Research and Interventions
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Respiratory viral infections research
- Innovation and Knowledge Management
- Capital Investment and Risk Analysis
- Connective tissue disorders research
- Extraction and Separation Processes
- Powdery Mildew Fungal Diseases
- Neuroblastoma Research and Treatments
- RNA Interference and Gene Delivery
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- Complex Systems and Decision Making
- Hepatitis C virus research
- Plant Pathogens and Resistance
- Musculoskeletal pain and rehabilitation
- Asian Industrial and Economic Development
- Water-Energy-Food Nexus Studies
Hitotsubashi University
2017-2022
The University of Tokyo
1997-2012
Institute of Agrobiological Sciences
2012
Nagoya University
2012
GlaxoSmithKline (India)
2011
Iwate University
2010
GlaxoSmithKline (Japan)
2006
Kobe Medical Center
2004
Okayama University
1986-2002
Fukushima University
2000-2001
CD4(+)CD25(+) regulatory T (Treg) cells are crucial mediators of autoimmune tolerance. The factors that regulate Treg cells, however, largely unknown. Here, we show deficiency in midkine (MK), a heparin-binding growth factor involved oncogenesis, inflammation, and tissue repair, attenuated experimental encephalomyelitis (EAE) because an expansion the cell population peripheral lymph nodes decreased numbers autoreactive T-helper type 1 (T(H)1) T(H)17 cells. MK ex vivo dose-dependent manner by...
A new method of quantitative measurement with a cybex machine is applied to the trunk muscles. The curves muscle torque and fatigue are easily obtained in clinical medicine. In normal controls, maximal greater back muscles than abdominal muscles, definite influence aging found both Furthermore, more fatigued by sustained contraction repeated contractions, role mechanism pain production prevention still be determined.
Currently approved therapies for age-related macular degeneration (AMD) are inhibitors against vascular endothelial growth factor (VEGF), which is a major contributor to the pathogenesis of neovascular AMD (nAMD). Intravitreal injections anti-VEGF drugs have shown dramatic visual benefits patients. However, significant portion patients exhibit an incomplete response therapy and, over extended management course, can lose vision, with formation submacular fibrosis as one risk factor. We...
We report reversal of the FGFR3-related skeletal dysplasia by RNA aptamer designed to neutralize FGFR3 ligand FGF2.
Midkine is a heparin-binding growth factor highly expressed in various cancers, including neuroblastoma, the most common extracranial pediatric solid tumor. Prognosis of patients with neuroblastoma which MYCN amplified remains particularly poor. In this study, we used transgenic model for midkine precancerous lesions sympathetic ganglia. Genetic ablation delayed tumor formation and reduced incidence. Furthermore, an RNA aptamer that specifically bound suppressed cells vitro vivo xenografts....
Fibroblast growth factor 2 (FGF2) plays a crucial role in bone remodeling and disease progression. However, the potential of FGF2 antagonists for treatment patients with diseases has not yet been explored. Therefore, we generated novel RNA aptamer, APT-F2, specific human characterized its properties vitro vivo. APT-F2 blocked binding to each four cellular receptors, inhibited FGF2-induced downstream signaling cells proliferation, restored osteoblast differentiation by FGF2. APT-F2P,...
Ingenol 3,5,20-triacetate (ITA), one of the ingenol derivatives, is a selective inhibitor human immunodeficiency virus (HIV) replication in vitro. ITA inhibited HIV strains MT-4 cells at concentrations 0.051 to 0.65 microM. This concentration was approximately 10(3)-fold lower than its cytotoxic threshold. The mechanism action primarily attributed inhibition viral adsorption host cells, but it distinct from by other inhibitors.
It has been reported that human immunodeficiency virus type 1 (HIV-1) bound to follicular dendritic cells (FDCs) remains highly infectious CD4(+) T even when it forms immune complexes with neutralizing antibody (HIV-1/IC). To elucidate the role of FDCs in HIV-1 transmission lymph nodes, we have isolated and purified from tonsils examined whether HIV-1/IC trapped on their surface is cells. our surprise, not but antibody-free could be transmitted Furthermore, contrast previous studies showing...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiadiazole Derivatives: Highly Potent and Specific HIV-1 Reverse Transcriptase InhibitorsYasuaki Hanasaki, Hiroyuki Watanabe, Kimio Katsuura, Hiromitsu Takayama, Seiichiro Shirakawa, Kentaro Yamaguchi, Shin-ichiro Sakai, Katsushi Ijichi, Masatoshi Fujiwara, Cite this: J. Med. Chem. 1995, 38, 12, 2038–2040Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June...
In order to justify the selection of therapeutic measures for low-back pain and sciatica, epidemiologic clinical studies were performed natural histories or long-term prognosis those symptoms. The main conclusions drawn in relation decision making are as follows: is more frequent than sciatica intermittent claudication, but latter disabling; acute attacks generally disabling chronic pain, frequency may be closely related poor duration; radiologic findings little value differentiating...
Ingenol 3,5,20-triacetate has recently been identified as a highly potent and selective inhibitor of HIV replication in vitro. To evaluate the potential ingenol derivatives anti-HIV agents, several have synthesized investigated for their activities, structure-activity relationships, possible mechanisms action. Among derivatives, 13-hydroxyingenol-3-(2,3-dimethylbutanoate)-13-dodecanoate (RD4-2138) proved to be replication. Its 50% effective concentration viral MT-4 cells was 0.07-0.5 nM...