A5072430303- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Tissue Engineering and Regenerative Medicine
- Complement system in diseases
- Phagocytosis and Immune Regulation
- Plant tissue culture and regeneration
- Immunodeficiency and Autoimmune Disorders
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Erythrocyte Function and Pathophysiology
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Extracellular vesicles in disease
- Reproductive Biology and Fertility
- CAR-T cell therapy research
Montreal Clinical Research Institute
2023-2024
McGill University
2023-2024
Universidad Nacional de Colombia
2020
Mesenchymal stromal cells (MSC) have been used in over 800 clinical trials with encouraging results the field of transplant medicine and chronic inflammatory diseases. Today, Umbilical Cord (UC)-derived MSC are second leading source for purposes, mainly due to its easy access superior immune-modulatory effects. Although underlying molecular mechanisms immune-suppressive activities not fully understood, research last decade strongly suggests that MSC-mediated benefits closely related...
Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion Ly49H+ natural killer (NK) cells, which are virus specific considered to be "adaptive" or "memory" NK cells. Here, we find that signaling lymphocytic molecule family receptors (SFRs), a group hematopoietic cell-restricted receptors, essential for the cells after MCMV infection. This activity is largely mediated CD48, an SFR broadly expressed on displaying augmented expression It also dependent CD48...
BACKGROUND The total nucleated cell dosage of umbilical cord blood (UCB) is an important factor in determining successful allogeneic hematopoietic stem transplantation after a minimum human leukocyte antigen donor‐recipient match. northern South American population need new‐generation bank that cryopreserves only units with high content, thereby increasing the likelihood use. Colombia set up public 2014; and, as result its research for improving new strategy UCB collection was developed....
Hematopoietic progenitor cell (HPC) transplantation is a treatment option for malignant and nonmalignant diseases. Umbilical cord blood (UCB) an important HPC source, mainly pediatric patients. It has been demonstrated that human leukocyte antigen (HLA) matching dose are the most features impacting clinical outcomes. However, UCB performed using low resolution HLA typing it unnoticed mismatches negatively impact transplant. Since we found differences in CD34+ viability after thawing of units...
Mesenchymal stromal cells (MSCs) hold promise for cell-based therapies due to their ability stimulate tissue repair and modulate immune responses. Umbilical cord-derived MSCs from Wharton jelly (WJ) offer advantages such as low immunogenicity potent modulatory effects. However, ensuring consistent quality safety throughout manufacturing process remains critical. RNA sequencing (RNA-seq) emerges a crucial tool assessing genetic stability expression dynamics in therapeutic products.
Abstract Monocytes and macrophages are involved in a wide range of biological processes parasitic diseases. The characterization the molecular mechanisms governing such usually requires precise control expression genes interest. We implemented tetracycline-controlled gene system U937 cell line, one most used vitro models for research human monocytes macrophages. Here we characterized U937-derived lines terms phenotypic (morphology marker expression) functional (capacity phagocytosis...