A5076679155- Growth Hormone and Insulin-like Growth Factors
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Hematopoietic Stem Cell Transplantation
- Drug Transport and Resistance Mechanisms
- Insect and Pesticide Research
- Pharmacological Effects and Toxicity Studies
- Food Allergy and Anaphylaxis Research
- Gout, Hyperuricemia, Uric Acid
- Pituitary Gland Disorders and Treatments
- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- RNA Interference and Gene Delivery
- Sexual Differentiation and Disorders
- Pharmacy and Medical Practices
- Neurological and metabolic disorders
- Osteoarthritis Treatment and Mechanisms
- Health Promotion and Cardiovascular Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Myocardial Infarction Research
- Erythrocyte Function and Pathophysiology
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Nutritional Studies and Diet
- RNA Research and Splicing
Pfizer (Japan)
2013-2022
Ryukoku University
2021-2022
Kyoto Pharmaceutical University
2010-2018
Pfizer (United States)
2014
Osaka University
2013
Tokyo Institute of Technology
1999-2013
Nihon University
2013
National Center for Geriatrics and Gerontology
2013
Kyoto Prefectural University of Medicine
2013
National Center for Global Health and Medicine
2013
Multiprotein bridging factor 1 (MBF1) is a coactivator which mediates transcriptional activation by interconnecting the general transcription TATA element-binding protein and gene-specific activators such as <i>Drosophila</i>nuclear receptor FTZ-F1 or yeast basic leucine zipper GCN4. The human homolog of MBF1 (hMBF1) has been identified but its function, especially in transcription, remains unclear. Here we report cDNA cloning functional analysis hMBF1. Two isoforms, term hMBF1α hMBF1β, have...
<b><i>Introduction:</i></b> Somatrogon is a long-acting recombinant human growth hormone being developed as once-weekly treatment for children with deficiency (GHD). The objective of this phase 3 study (NCT03874013) was to compare the efficacy and safety somatrogon once-daily Genotropin in Japanese GHD. <b><i>Methods:</i></b> In open-label, randomized, active-controlled study, 44 prepubertal GHD (boys: &#x3c;11 years; girls: &#x3c;10...
Background: Concomitant anticoagulant therapy may further reduce the risk of thrombotic events in patients with acute coronary syndrome (ACS) when given addition to current standard antiplatelet therapies. This Phase II, randomized, double-blind, placebo-controlled study Japanese ACS assessed bleeding apixaban compared placebo combination therapy, and followed a similar design APPRAISE-1, larger global II study. Methods Results: Patients recently diagnosed were randomized receive 2.5mg twice...
Abstract It is known that the lipid‐lowering agent pravastatin, which not metabolized by cytochrome P450, eliminated as an unchanged drug in bile and urine. interesting to note non‐renal clearance of pravastatin end‐stage renal failure patients decreased compared with healthy volunteers. This study investigated influence uremic serum toxins on transport mechanisms elucidate cause patients. Caco‐2 Hep3B cells were used models intestinal epithelial hepatocytes respectively. Normal...
Data collected by the Japanese Ministry of Health, Labour and Welfare (MHLW), namely data from Specific Health Checkups Guidance (MHLW-SH) National Nutrition Survey (MHLW-H&N) allow assessment blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), hemoglobin A1c (HbA1c) in Japan. Recently, a large database employment-based health insurance has been developed MinaCare Co. Ltd. A retrospective, cross-sectional study using healthcare checkup was designed to investigate distribution...
Abstract Objectives The purpose of this study was to clarify the cause decreased metabolic clearance losartan in patients with end-stage renal failure. influence serum from haemodialysis (uraemic serum) and uraemic toxins on metabolism EXP-3174 investigated vitro. Methods formation estimated using pooled human liver microsomes. 3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid, hippuric indole-3-acetic 3-indoxyl sulfate p-cresol were used as toxins. Key findings Uraemic potently In addition,...
Predicting clinical outcomes can be difficult, particularly for life-threatening events with a low incidence that require numerous cases. Our aim was to develop and validate novel algorithms identify major adverse cardiovascular (MACEs) from claims databases. We developed based on the data available in database International Classification of Diseases, Tenth Revision (ICD-10), drug prescriptions, medical procedures. also employed Jichi Medical University Hospital, Japan, period between...
TBP-like protein (TLP) is structurally similar to the TATA-binding (TBP) and thought have a transcriptional regulation function. Although TLP has been found form complex with transcription factor IIA (TFIIA), in vivo functions of TFIIA for are not clear. In this study, we analyzed interaction between TFIIA. We determined biophysical properties Dissociation constants versus TBP were 1.5 10 nm, respectively. Moreover, dissociation rate constant (1.2 × 10–4/m·s was significantly lower than that...
Abstract Xanthine oxidoreductase (XOR) inhibitors, such as allopurinol and febuxostat, inhibit the catalysis of serum uric acid (SUA) synthesis. In doing so, they are thought to improve vascular endothelial function in patients with hyperuricemia cardiovascular risk by reducing increases SUA reactive oxygen species levels. We performed a retrospective cohort study evaluate effects topiroxostat, novel XOR inhibitor, on measured flow‐mediated dilation (FMD) ultrasonography. total, 23 were...
The melanocortin 4 receptor (MC4R) plays an important role in the regulation of appetite and energy expenditure humans rodents. Impairment MC4R signaling causes severe obesity. mainly couples to G-protein Gs. Ligand binding activates adenylyl cyclase resulting increased intracellular cAMP levels. acts as a secondary messenger, regulating various cellular processes. can also couple with Gq other pathways. Therefore, contribution MC4R/Gs metabolism remains unclear. To study effect Gs...
Vesnarinone is a synthetic quinolinone derivative used in the treatment of cardiac failure and cancer. It also known to cause agranulocytosis as side effect, which restricts its use, although mechanism underlying not well understood. Here, we show that vesnarinone binds valosin-containing protein (VCP), interacts with polyubiquitinated proteins essential for degradation I<i>κ</i>B<i>α</i> activate nuclear factor (NF)<i>κ</i>B. We impairs I<i>κ</i>B<i>α</i>, impairment result inhibition...
Abstract Background: Positive transcription elongation factor b (P‐TEFb), which phosphorylates the carboxyl‐terminal domain (CTD) of RNA polymerase II (RNAPII), is comprised catalytic subunit cyclin‐dependent kinase 9 (CDK9) and regulatory cyclin T. The activity transcriptional activation potential P‐TEFb sensitive to various compounds, including H‐8, 5,6‐dichloro‐1‐β‐d‐ribofuranosylbenzimidazole (DRB), flavopiridol. Results: We investigated molecular mechanism H‐8 inhibition CDK9 using...
Immortalized cloned human chondrocytes isolated from a normal (Ch-4, 8, N) and an osteoarthritis patient (Ch-8-OA) were established by introduction of recombinant SV40-adenovirus vector containing SV40 early gene. These cells exhibited continuous proliferative capacity in monolayer culture showed chondrocytic characteristics that they positive for alkaline phosphatase collagen type II. When treated with IL-1alpha, the growth was inhibited. IL-1alpha induced production IL-6, GM-CSF TNFalpha...
Races and competitions over 100 miles have recently increased. Limited information exists about the effect of multiday continuous endurance exercise on blood glucose control appropriate intake food drink in a female athlete. The present study aimed to examine variation its relationship with nutritional running performance professional athlete during 155.7 h ultramarathon race little sleep.We divided mountain course 438 km into 33 segments by timing gates continuously monitored participant's...
A post-marketing surveillance study (STANDARD-VTE) evaluated the real-world safety and effectiveness of apixaban in Japanese patients prescribed for either treatment venous thromboembolism (VTE) or prevention recurrent VTE.