A5068703849- Migraine and Headache Studies
- Neurological Complications and Syndromes
- Trigeminal Neuralgia and Treatments
- Cerebrospinal fluid and hydrocephalus
- Neurological and metabolic disorders
- Musculoskeletal pain and rehabilitation
- Moyamoya disease diagnosis and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Fetal and Pediatric Neurological Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Placebo Effect
- Psychosomatic Disorders and Their Treatments
- Spinal Dysraphism and Malformations
- Olfactory and Sensory Function Studies
- Cardiovascular Syncope and Autonomic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Nausea and vomiting management
- Maternal Mental Health During Pregnancy and Postpartum
- Multiferroics and related materials
- Pain Management and Opioid Use
- Space Science and Extraterrestrial Life
- Space exploration and regulation
- Fibromyalgia and Chronic Fatigue Syndrome Research
Taipei Veterans General Hospital
2019-2025
National Yang Ming Chiao Tung University
2018-2025
Instituto de Investigación Médica Mercedes y Martín Ferreyra
2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2024
Universidad Nacional de Córdoba
2024
National Taipei University
2020
National Yang Ming University Hospital
2018-2019
In an effort to improve migraine management around the world, International Headache Society (IHS) has here developed a list of practical recommendations for acute pharmacological treatment migraine. The are categorized into optimal and essential, in order provide options all possible settings, including those with limited access medications.
Objective To evaluate human glymphatics and meningeal lymphatics noninvasively. Methods This prospective study implemented 3‐dimensional (3D) isotropic contrast‐enhanced T2 fluid‐attenuated inversion recovery (CE‐T2‐FLAIR) imaging with a 3T magnetic resonance machine to cerebral in patients reversible vasoconstriction syndrome (RCVS) (n = 92) or without 90) blood–brain barrier (BBB) disruption diseased control group cluster headache 35). The contrast agent gadobutrol (0.2mmol/kg [0.2ml/kg])...
Many single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their associations endophenotypes or subtypes are scarce. We aimed investigate the of pre-identified susceptibility loci in Taiwanese subtypes, including chronic and allodynia.The six SNPs identified from our previous study, TRPM8 rs10166942, LRP1 rs1172113, DLG2 rs655484, GFRA1 rs3781545, UPP2 rs7565931, GPR39 rs10803531, endophenotypes, allodynia were tested....
Background The present study aimed to evaluate the risk and impact of fibromyalgia in relation headache frequency migraine patients. Methods This cross-sectional involved patients from a regional hospital tertiary medical center. Diagnoses were made according International Classification Headache Disorders, 3rd edition, modified 2016 American College Rheumatology diagnostic criteria, respectively. Clinical data, including Fibromyalgia Symptoms (FS) scale revised Impact Questionnaire (FIQR),...
Previous studies regarding the quantitative sensory testing are inconsistent in migraine. We hypothesized that results were influenced by headache frequency or migraine phase.This study recruited chronic and episodic patients as well healthy controls. Participants underwent testing, including heat, cold, mechanical punctate pain thresholds at supraorbital area (V1 dermatome) forearm (T1 dermatome). Prospective diaries used for phase when was performed.Twenty-eight migraine, 64 32 controls...
Background and Purpose— Reversible cerebral vasoconstriction syndrome (RCVS) has a unique temporal course of vasoconstriction. Blood-brain barrier (BBB) breakdown is part the pathophysiology RCVS, but its unknown. We aimed to investigate profile BBB relevant clinical profiles in large sample size. Methods— In this prospective observatory bicenter study, patients who underwent contrast-enhanced fluid-attenuated inversion recovery magnetic resonance imaging within 2 months from onset were...
Abstract Background Chronic headache may persist after the remission of reversible cerebral vasoconstriction syndrome (RCVS) in some patients. We aimed to investigate prevalence, characteristics, risk factors, and impact post-RCVS headache. Methods prospectively recruited patients with RCVS collected their baseline demographics, including psychological distress measured by Hospital Anxiety Depression scale. evaluated whether developed 3 months onset. The manifestations headache-related...
We aimed to assess the differences in quantitative sensory testing between chronic migraine and healthy controls explore association pain sensitivities outcomes following preventive treatment.In this prospective open-label study, preventive-naïve were recruited, cold, heat, mechanical punctate, pressure thresholds over dermatomes of first branch trigeminal nerve thoracic measured by at baseline. Chronic migraines treated with flunarizine treatment response was defined as ≥50% reduction...
Abstract Background The pathophysiology of the reversible cerebral vasoconstriction syndrome (RCVS) remains enigmatic and role glymphatics in RCVS has not been evaluated. We aimed to investigate glymphatic dynamics its clinical correlates. Methods prospectively evaluated function patients, with subjects healthy controls (HCs) recruited between August 2020 November 2023, by calculating diffusion-tensor imaging along perivascular space (DTI-ALPS) index under a 3-T MRI. Clinical vascular...
Abstract Objective To compare the real‐world effectiveness and tolerability of calcitonin gene‐related peptide (CGRP) monoclonal antibodies (mAbs) onabotulinumtoxinA in chronic migraine (CM) patients. Methods This multicenter study involved retrospective analysis prospectively collected data CM patients treated with CGRP mAbs or onabotulinumtoxinA, including difficult‐to‐treat (DTT) (i.e., ≥3 preventive failures). Treatment outcomes were determined at 6 months based on prospective headache...
Reversible cerebral vasoconstriction syndrome (RCVS) is a rare, but increasingly recognised cerebrovascular condition with an estimated annual age-standardised incidence of approximately three cases per million. Knowledge about risk factors and triggering conditions information prognosis optimal treatment in these patients are limited.The REversible Vasoconstriction intERnational CollaborativE (REVERCE) project aims to elucidate the epidemiological clinical characteristics RCVS by collecting...
Dependence behaviors are common in patients with medication-overuse headache (MOH). This prospective study aimed to characterize dependence MOH by using Leeds questionnaire (LDQ), and determine the clinical utility of LDQ diagnosis MOH. In total, 563 consecutive chronic migraine (CM) (451F/112M, mean age 41.7 ± 12.0 years) were recruited, including 320 (56.8%) (254F/66M, 42.3 11.6 years). scores positively correlated monthly frequency acute medication use (Spearman’s rho = 0.680, p <...
The present study aimed to compare sex differences in the clinical manifestations related dependence behaviors medication-overuse headache (MOH).Consecutive patients with newly diagnosed chronic migraine (CM) and without MOH based on Third Edition of International Classification Headache Disorders (ICHD-3) were enrolled prospectively from clinic a tertiary medical center. Demographics profiles collected by using questionnaire, which included current use tobacco, alcohol, caffeinated...
Half of the sufferers reversible cerebral vasoconstriction syndrome (RCVS) exhibit imaging-proven blood-brain barrier disruption. The pathogenesis disruption in RCVS remains unclear and mechanism-specific intervention is lacking. We speculated that cerebrovascular dysregulation might be associated with RCVS. Hence, we aimed to evaluate whether dynamic autoregulation altered patients could disruption.A cross-sectional study was conducted from 2019 2021 at headache clinics a national tertiary...
Background To differentiate primary headache associated with sexual activity from other devastating secondary causes. Methods In this prospective cohort, we recruited consecutive patients at least 2 attacks of the clinics or emergency department a national medical center 2005 to 2020. Detailed interview, neurological examination, and serial thorough neuroimaging including brain magnetic resonance imaging angiography scans were performed on registration during follow-ups. Patients categorized...
Abstract Objective To investigate the distribution, clinical associations, and treatment responses for most bothersome symptoms of migraine in a large sample patients with Taiwan. Background The symptom is recently recommended as co‐primary endpoint trials acute migraine. However, observational studies have been conducted United States Europe, photophobia representing common symptom. Methods Patients who were newly diagnosed by headache specialists Taipei Veterans General Hospital recruited....
Abstract Objective Quantitative sensory testing is widely used in clinical and research settings to assess the functions of healthy subjects patients. It importance establish normative values a population provide reference for studies involving Given absence pain thresholds Taiwan, aim this study was report future Taiwanese compare differences between male female participants. Methods Healthy adults without any chronic or acute condition were recruited. The assessed over cephalic...
<h3>Background and Objectives</h3> Blood-brain barrier (BBB) disruption has been proposed to be important in the pathogenesis of reversible cerebral vasoconstriction syndrome (RCVS), but not all patients present an identifiable macroscopic BBB disruption; that is, visible contrast leakage on contrast-enhanced T2 fluid-attenuated inversion recovery imaging. This study aimed evaluate microscopic permeability its dynamic change with RCVS. <h3>Methods</h3> prospective cohort implemented 3T MRI....
Artery of Percheron (AOP) infarction, a rare cause acute altered mental status (AMS), is characterized by bilateral paramedian thalamic infarction. The aim this study was to review the clinical manifestation, radiological patterns, treatment, and prognosis patients with AOP This retrospective case series included infarction from 2009 2020 medical center in Taiwan. We defined as magnetic resonance imaging, were further categorized their additional territorial involvements. determined outcomes...