A5101418313- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- Plant-derived Lignans Synthesis and Bioactivity
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Liver Disease and Transplantation
- Genetic factors in colorectal cancer
- Pharmacological Effects of Natural Compounds
- Graphene and Nanomaterials Applications
- Metastasis and carcinoma case studies
- Kruppel-like factors research
- Drug-Induced Hepatotoxicity and Protection
- Sphingolipid Metabolism and Signaling
- Drug Solubulity and Delivery Systems
- Gastrointestinal Tumor Research and Treatment
- Molecular Spectroscopy and Structure
- Protein Interaction Studies and Fluorescence Analysis
- Sarcoma Diagnosis and Treatment
- Spectroscopy and Laser Applications
- Liver Disease Diagnosis and Treatment
- Lipid Membrane Structure and Behavior
- Cancer Treatment and Pharmacology
- Metal complexes synthesis and properties
Hangzhou Medical College
2019-2024
Zhejiang Provincial People's Hospital
2014-2024
Chengdu University of Technology
2021-2023
Nanjing University
2016
Despite substantial efforts to develop novel therapeutic strategies for treating hepatocellular carcinoma (HCC), the effectiveness and specificity of available drugs still require further improvement. Previous work has shown that exogenous ceramide can play a key role in inducing apoptotic death cancer cells, however poor water-solubility this compound hampered its use treatment. In present study, we used polyethylene glycol (PEG) polyethylenimine (PEI) co-conjugated ultra-small nano-GO...
The aim of this study was to discuss the role c-KIT mutation in pathogenesis gastrointestinal stromal tumors (GISTs) and analyze its correlation with proliferation apoptosis. PDGFRA genotypes were examined by deoxyribonucleic acid sequencing. Immunohistochemistry performed determine expression levels Kit, Ki-67 (proliferation marker), apoptotic protease-activating factor (APAF)-1 (apoptosis marker) relationship between their three genes. In 68 cases examined, 44 (64.7%) showed mutations one...
Abstract Podophyllotoxin (PPT) is an active natural pharmaceutical component with potent anticancer activity. However, due to its poor water solubility and serious side effects, medical applications are limited. In this work, we synthesized a series of PPT dimers, which can be self-assembled into stable nanoparticles 124–152 nm in aqueous solution significantly increase the solution. addition, dimer exhibited high drug loading capacity (>80%) could store at 4 °C state good stability for...
Abstract Oncolytic adenoviruses (oADV) are promising cancer treatment agents. However, in vivo hepatic sequestration and the host immunologic response against agents limit therapeutic potential of oADVs. In this study, we present a combined method with rational design for improving oADV infection efficiency, immunogenicity, efficacy by self-biomineralization. We integrated biomimetic nucleopeptide W6p into capsid using reverse genetics, allowing calcium phosphate mineralization to be...
<p>Figure S10. Preparation process of oADV-W6-CaP and schematic diagram oADV-W6-CaP-induced cancer immunotherapy.</p>
<p>Figure S2. (A) Competition assay with CAR-specific antibody in SW1990, BxPC-3 and MCF-7 cells. (B) Neutralization of oADV-W6-CaP or oADV-W6 cells anti-Ad5 serum at indicated dilutions.</p>
<p>Figure S4. oADV-W6-CaP promotes activation of the type I IFN pathway in Panc02, CT26 and SCC-7 cells.</p>
<p>Figure S6. Biological safety of the oADV-W6-CaP.</p>
<p>Figure S9. Up-regulation of PD-L1 and CD47 expression on tumor cells after oADV-W6-CaP infection.</p>
<p>Figure S7. Immuno-gating strategies of flow cytometry analysis.</p>
<p>Table S1. Primer sequences used for qRT-PCR analysis and probe</p>
<p>Figure S1. Particle size of bare oADV-W6 and oADV-W6-CaP.</p>
<div>Abstract<p>Oncolytic adenoviruses (oADV) are promising cancer treatment agents. However, <i>in vivo</i> hepatic sequestration and the host immunologic response against agents limit therapeutic potential of oADVs. In this study, we present a combined method with rational design for improving oADV infection efficiency, immunogenicity, efficacy by self-biomineralization. We integrated biomimetic nucleopeptide W6p into capsid using reverse genetics, allowing calcium...
<p>Figure S8. (A) Flow cytometric analysis of the proportion CD3+, CD8+ and CD4+ T cells in splenocytes. (B) The virus titers tumor sera 4T1 mice were quantified by TCID50 method. (C) relative content tumors qPCR assay.</p>
<p>Figure S3. In vitro tests of virus thermostability.</p>
<p>Figure S5. Individual tumor growth curve. The volume was measured every two or three days. Once the of mouse exceeded 2000 mm3, it no longer measured.</p>