A5050298956- Anesthesia and Pain Management
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Nausea and vomiting management
- Airway Management and Intubation Techniques
- Pain Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Tracheal and airway disorders
- Immune Response and Inflammation
- Genetics and Neurodevelopmental Disorders
- Ion Channels and Receptors
- Cardiac, Anesthesia and Surgical Outcomes
- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
- Gastrointestinal disorders and treatments
- Nosocomial Infections in ICU
- Pancreatitis Pathology and Treatment
- Sepsis Diagnosis and Treatment
- Heat shock proteins research
- Advancements in Transdermal Drug Delivery
- Neuroscience and Neuropharmacology Research
- Acute Kidney Injury Research
Minhang District Central Hospital
2023
Fudan University
2023
Shanghai Jiao Tong University
2014-2021
Renji Hospital
2013-2021
Guiyang Medical University
2020
Affiliated Hospital of Guizhou Medical University
2020
In-Q-Tel
2014
Pain and cartilage destruction caused by rheumatoid arthritis (RA) are major challenges during clinical treatment. Traditional systemic administration not only has obvious side effects but also provides limited relief for local symptoms in joints. Local delivery of therapeutics RA treatment is a potential strategy rapid intraarticular release. In this study, we prepared thermoresponsive injectable hydrogel mixing pluronic F127 (F127) hyaluronic acid (HA) with poly (γ-glutamic acid) (PGA)...
Focal ischemia/reperfusion (I/R) injury induced cerebral inflammation, aggravates brain damage. The aim of the present study was to investigate protective mechanisms dexmedetomidine (DEX) on I/R in rats. Sprague‑Dawley rats were divided seven experimental groups (18 rats/group): Sham surgery; middle artery occlusion (MCAO) surgery (90 min); DEX10 [10 µg/kg intraperitoneal (i.p.) injection 30 min prior MCAO]; DEX50 (50 i.p. MCAO); DEX100 (100 DEX50+Yohimbine [YOH; 5 mg/kg 10 DEX i.p.)...
ABSTRACT Background: Reduced B cell numbers play a critical role in sepsis immunosuppression. The of B-cell maturation regulated by T follicular helper (Tfh) cells reduced during remains unclear. We tested the hypothesis that impaired contributes to numbers. Design: Retrospective study and observational prospective cohort study. Settings: Critical care units. Methods: To identify exact lymphocyte counts affect prognosis sepsis, we first conducted retrospective Then study, differences...
The causative mechanisms triggering myofascial pain syndrome (MPS) are still in debate. It is becoming evident that mitochondrial dysfunction may regulate pathways controlling MPS. aim of this study was to investigate whether AMPK-PGC-1α-SIRT3 axis associated with depression function the rat MPS model.A total 32 Sprague-Dawley rats were randomly divided into control group and experimental group. expression level mRNA protein gastrocnemius medialis (GM) analyzed by Western blot RT-PCR....
TRPA1 is pivotal in cold hypersensitivity, but its regulatory mechanisms inflammatory hyperalgesia remain poorly understood. We show here that the upregulation of SUMO1-conjugated protein levels a complete Freund's adjuvant (CFA)-induced pain model enhances mRNA stability, ultimately leading to increased expression levels. further demonstrate hnRNPA1 binds mRNA, and SUMOylation, upregulated CFA-induced pain, contributes stabilizing by accumulating cytoplasm. Moreover, we find wild-type viral...
Increasingly more aged people with Alzheimer's disease (AD) must undergo surgery general anesthesia for various reasons. Knowing the potency of common inhaled anesthetics on AD patients is important to minimize quantity anesthetics. Previous studies indicated that transgenic mice were resistant than wild-type mice. However, are associated early-onset familial AD, which accounts only 5% total in clinic. Confirming results using other animal models still necessary.The aim this study was...
Abstract Background Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder that characterized by motor symptoms such as tremor, rigidity, slowness of and problems with gait. Large-scale meta-analyses genome-wide association studies (GWAS) have identified few susceptibility loci in patients sporadic PD. The aim this study was to investigate the between NMD3 single nucleotide polymorphism (SNP) PD South China. Methods A total 217 were recruited genotyped using SNaPshot...
Abstract Bcakground Parkinson's disease (PD) is a progressive degenerative disorder of the basal ganglia that not only affects initiation and execution voluntary movements, but also nonmotor features. The aim was to investigate association between NMD3 symptoms PD patients in Chinese. Methods 217 were recruited this study. All evaluated by Sniffin’ Sticks 16 (SS-16), Hamilton anxiety rating scale depression scale, 39-item Questionnaire (PDQ-39) MDS - Unified Rating Scale (MDS-UPDRS)....
Abstract Bcakground: Parkinson's disease (PD) is a progresasive neurodegenerative movement disorder which characterized by motor symptoms such as tremor, rigidity, slowness of and problems with gait. Large-scale meta-analyses genome-wide association studies (GWAS) have identified few susceptibility loci in sporadic PD. The aim this study was to investigate the between NMD3 single nucleotide polymorphism (SNP) PD patients southern Chinese. Methods: A total 217 were recruited genotyped using...
Abstract Bcakground Parkinson's disease (PD) is a progressive degenerative disorder of the basal ganglia that not only affects initiation and execution voluntary movements, but also nonmotor features. The aim was to investigate association between NMD3 symptoms PD patients in Chinese. Methods 217 were recruited this study. All evaluated by Sniffin’ Sticks 16 (SS-16), Hamilton anxiety rating scale depression scale, 39-item Questionnaire (PDQ-39) MDS - Unified Rating Scale (MDS-UPDRS)....
Background: Postoperative pulmonary complications are serious, and especially common in geriatric surgical patients. Laryngeal mask airways endotracheal intubation the two most airway approaches for patients who require general anaesthesia. less invasive than easier to insert, but do not protect from aspiration. Which approach is preferable remains unknown. We therefore tested primary hypothesis that a composite of in-hospital postoperative with laryngeal after having elective noncardiac...