A5085417054- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Glycosylation and Glycoproteins Research
- PI3K/AKT/mTOR signaling in cancer
- Advances in Oncology and Radiotherapy
- Pancreatic function and diabetes
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Economic and Financial Impacts of Cancer
- SARS-CoV-2 and COVID-19 Research
- Urologic and reproductive health conditions
- Neuropeptides and Animal Physiology
- Fungal Infections and Studies
- Cytokine Signaling Pathways and Interactions
- Genetics and Neurodevelopmental Disorders
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Single-cell and spatial transcriptomics
- Antifungal resistance and susceptibility
- COVID-19 epidemiological studies
- Infectious Diseases and Mycology
Biogem
2015-2023
Oslo University Hospital
2021
Istituto di Farmacologia Traslazionale
2019
// Donatella Malanga 1 , Carmela De Marco 1, 2 Ilaria Guerriero Fabiana Colelli Nicola Rinaldo Marianna Scrima Teresa Mirante 3 Claudia Vitis 7 Pietro Zoppoli Michele Ceccarelli 4 Miriam Riccardi Maria Ravo 5 Alessandro Weisz Antonella Federico 6 Renato Franco Gaetano Rocco Rita Mancini 8 Antonia Rizzuto Elio Gulletta 9 Gennaro Ciliberto Giuseppe Viglietto Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia, Catanzaro, Italy Biogem scarl, Istituto Ricerche...
Hyperactivation of the PI3K/AKT pathway is observed in most human cancer including lung carcinomas. Here we have investigated role miRNAs as downstream targets activated signaling Non Small Cell Lung Cancer (NSCLC). To this aim, miRNA profiling was performed epithelial cells (BEAS-2B) expressing active AKT1 (BEAS-AKT1-E17K), PI3KCA (BEAS-PIK3CA-E545K) or with silenced PTEN (BEAS-shPTEN).Twenty-four differentially expressed common to BEAS-AKT1-E17K, BEAS-PIK3CA-E545K and BEAS-shPTEN were...
MicroRNAs (miRNAs), formed by cleavage of pre-microRNA the endoribonuclease Dicer, are critical modulators cell function post-transcriptionally regulating gene expression.Selective ablation Dicer in AQP2-expressing cells (DicerAQP2Cre+ mice) was used to investigate role miRNAs kidney collecting duct mice.The mice had severe polyuria and nephrogenic diabetes insipidus, potentially due greatly reduced AQP2 AQP4 levels. Although epithelial sodium channel levels were decreased cortex increased...
<b><i>Introduction:</i></b> Since the pandemic of COVID-19 started from December 2019, remarkable numbers infections and deaths associated with have been recorded worldwide. End-stage kidney disease patients on dialysis are particularly at high risk due to impairments in innate adaptive immune systems. Vaccination (DP) still remains challenging because variable response a low seroconversion rate compared healthy participants (HP). Therefore, it is urgently necessary...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. This due to its aggressive course, late diagnosis and intrinsic drugs resistance. The complexity of the tumor, in terms cell components heterogeneity, has led approval few therapies with limited efficacy. study early stages carcinogenesis provides opportunity for identification actionable pathways that underpin therapeutic Methods We analyzed 43 Intraductal papillary mucinous neoplasms (IPMN) (12 Low-grade 31...
Endoderm-derived organs as liver and pancreas are potential targets for regenerative therapies, thus, there is great interest in understanding the pathways that regulate induction specification of this germ layer. Currently, knowledge molecular mechanisms guide vivo endoderm restricted by lack early specific markers. Nephrocan (Nepn) a gene whose expression characterizes stages murine (E7.5–11.5) encodes secreted N-glycosylated protein. In present study, we report identification new...
•The SIC conducted a survey on the effect of COVID-19 lockdown cancer research laboratories in Italy.•The impact activities was high, with complete or partial shutdown >80% laboratories.•Response to pandemic fragmented different strategies adopted without clearly defined contingency plan.•An adequate organization centers is urgently needed ensure laboratory safe environment. BackgroundItaly among first countries hit by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection....
The β2-adrenergic receptor has been shown to be involved in neuroendocrine differentiation and contribute the development of aggressive prostate cancer. In this study we have investigated whether miR-196a plays a role regulation LNCaP cancer cell line. Our results show that expression is elevated cells with reduced levels after stably transfection three different shRNAs. Furthermore, treatment β-blockers showed upregulation strictly related low not inhibition signaling activity. Finally,...
Pancreatic organogenesis is a multistep process that requires the cooperation of several signaling pathways. In this context, role pancreatic mesenchyme important to define epithelium development; nevertheless, precise space–temporal activation still needs be clarified. This study reports dissection embryogenesis, highlighting molecular network surrounding epithelium–mesenchyme interaction. To investigate crosstalk, and mesenchyme, at embryonic day 10.5, were collected through laser capture...
Abstract BACKGROUND. Intraductal papillary mucinous neoplasm (IPMN) are the most prevalent pancreatic cystic neoplasms which may progress to ductal adenocarcinoma (PDAC), lethal solid malignancy. Therefore, patients suffering from this condition represent ideal population where address efforts of identifying prevention or interception strategies. Here, we used spatial transcriptomics on IPMNs different grade identify mechanisms that associated progression those lesions toward invasive...