A5011580349- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Pituitary Gland Disorders and Treatments
- Retinal Imaging and Analysis
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Diabetes Management and Research
- Thyroid and Parathyroid Surgery
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Dietary Effects on Health
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Hypothalamic control of reproductive hormones
- Glioma Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Schizophrenia research and treatment
- Apelin-related biomedical research
- Voice and Speech Disorders
University Medical Centre Mannheim
2006-2022
Heidelberg University
2006-2022
University Hospital Heidelberg
2006-2022
PHV Dialysezentrum
2019-2022
Praxis
2021
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2020
Chuvash State Pedagogical University
2020
University of Mannheim
2013-2015
Kurume University
2013
Medical University of Lublin
2013
Objective: It was hypothesized that resistin links obesity with diabetes, but this has not been studied in children and adolescents to date. Patients: We determined serum levels of 135 obese (body mass index, 32.0 ± 6.2 kg/m2; age, 12.6 3.4 yr) 201 lean 18.7 2.4 12.5 2.5 by a newly developed extensively evaluated in-house immunoassay. These results were controlled for their association markers puberty, obesity, insulin sensitivity. Results: The analytical evaluation our assay revealed...
Leptin is bound in human blood by a high affinity binding protein, which appears to be identical with the soluble leptin receptor (sOB-R). Using ligand-mediated immunofunctional assay for determination of serum sOB-R, we investigated its course during childhood, puberty, and adolescence large cohort 581 healthy children adolescents small group 13 patients anorexia nervosa. In first years life, sOB-R detectable remarkably concentrations. Thereafter, continuous decline levels was found....
Leptin, a 167 amino acid peptide, is known to influence the gonads via direct and indirect effects. Recent studies provide contradictory proposition about peripheral impact of leptin in male gonads. Thus, we examined its receptors human seminal plasma ejaculated spermatozoa by Western blot technique fluorescence microscopy. In found free band (16 kDa) an anti-leptin polyclonal antibody. Incubation with recombinant caused statistically significant increase amount (p < 0.01) supports this...
<i>Background:</i> We have developed a rapid, sensitive and quantitative in vitro assay for leptin based upon its ability to bind the soluble extracellular domain of receptor (sOB-R). Such an is theoretically capable differentiating between physiologically active molecules from those with modified, either enhanced or reduced, binding activity. <i>Methods:</i> A preparation sOB-R was immobilized capture serum samples standards. Anti-leptin antibodies that had been...
Leptin is a 167-amino acid protein that stimulates gonadotrophin-releasing hormone secretion and exerts indirect effects on the gonads via neuropeptide Y, NPY. Recent research has suggested leptin may also have an effect testosterone secretion. To investigate role of in reproduction, testicular tissue seminal plasma was examined relation to serum, semen sample qualities vasectomy. Seminal serum 64 infertility patients, 15 individuals after vasectomy, were assayed for using competitive 'in...
Aims/hypothesis: To evaluate the potential effectiveness of 'carbohydrate days' as a dietary intervention to overcome insulin resistance in type 2 diabetes.
Cushing's syndrome causes considerable harm to the body if left untreated, yet often remains undiagnosed for prolonged periods of time. In this study we aimed test whether face classification software might help in discriminating patients with from healthy controls. Diagnostic study. Using a regular digital camera, took frontal and profile pictures 20 female 40 sex- age-matched Semi-automatic analysis was performed by comparing texture geometry within grid nodes placed on pictures. The...
A recent randomized trial showed that pretreatment of the brain-dead donor with low-dose dopamine improves immediate kidney graft function, by limiting injury from cold storage (ClinicalTrials.gov Identifier: NCT00115115). This study determines whether exposure to desmopressin (1-deamino-8-d-arginine-vasopressin [DDAVP]) before organ retrieval affects renal transplant outcome.This retrospective multicenter cohort study, nested in database trial, includes 264 deceased heart-beating donors...
The vital renal replacement therapy makes it impossible for dialysis patients to distance themselves socially. This results in a high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and developing coronavuris disease 2019, with excess mortality due burden immunosuppression. We determined the efficacy 100-µg booster mRNA-1273 (Moderna, Cambridge, MA, USA) 6 months after two doses BNT162b2 (BioNTech/Pfizer, Mainz, Germany/New York, 194 SARS-CoV-2-naïve patients.
Obesity and the metabolic syndrome (MetS) are associated with endothelial dysfunction (ED). An established method to determine ED is retinal vessel analysis. MetS, but obese patients not matching all criteria of MetS therefore defined as metabolically healthy subjects (MHOS) exist. Bariatric surgery may be an appropriate option treat morbid obesity. The aim this study was compare MHOS post bariatric in adipocytokine patterns ED. Arterio-venous ratio (AVR) diameters from photographs...
Resistant hypertension is still a challenge and reserve antihypertensive agents are often necessary to achieve blood pressure control. One minoxidil, direct vasodilator that known for its strong pressure–lowering effect, but contemporary studies sparse. The authors retrospectively analyzed 54 inpatients with uncontrolled despite the combined use of current agents. To investigate effect minoxidil when added other agents, was evaluated at time treatment initiated discharge. Minoxidil...
Intraoperative localization of pathologic parathyroid glands is major importance for the hyperparathyroidism treatment. Based on small size and anatomic variability, can be very challenging. The current practice to compare preoperative ultrasonography with Technetium-99m sestamibi scintigraphy (MIBI) plan resection accordingly. In this study, we implemented indocyanine green angiography intraoperative glands.This a retrospective analysis 37 patients primary, secondary, or tertiary who were...
Zusammenfassung Einleitung Komplette Schilddrüsenresektionen sind mit einer relativ hohen Rate an passagerem oder auch persistierendem Hypoparathyreoidismus vergesellschaftet. Die Sicherung und Lokalisation vitalen Nebenschilddrüsengewebes während der Schilddrüsenresektion durch den Einsatz intraoperativer Indocyaningrün-Fluoreszenz (ICG-Fluoreszenz) wurde jüngst in retrospektiven prospektiven Studien als intraoperatives Hilfsmittel zur Vermeidung des postoperativen beschrieben....
Untreated non-alcoholic fatty liver disease (NAFLD) may have significant consequences including an increase in mortality and cardiovascular injury. Thus, early detection of NAFLD is currently believed not only to prevent liver-related but also mortality. However, almost nothing known about coexisting patients with coronary artery (CAD). We investigated the impact surrogate scores fibrosis a large cohort referred angiography. Modeling common NALFD scores, fibrosis-4 index (FIB-4) score (NFS),...
<h3>Objective</h3> To assess retinopathy and its risk factors in an obesity WHO III cohort. <h3>Methods</h3> In the <i>Mannheim Obesity Study</i>, 277 subjects with aged 18–64 years were examined a cross-sectional approach. Screening for was performed using 3-field retinal photography. Endothelial function assessed arteriole-to-venule ratio flicker light analysis. Subjects without analysed anthropometry, metabolic, vascular renal parameters. <h3>Results</h3> Retinopathy found 18 of (6.5%)....
It has been shown that face classification software can help distinguish between subjects with and without acromegaly on regular photographs. In this project we have method be provided to the medical public in a first clinical application.
Introduction and Aims: Dipeptidyl peptidase-4 (DPP-4) is an enzyme which mainly degrades incretins such as glucagon like peptide-1 (GLP-1) altered in a variety of inflammatory disorders.DPP-4 GLP-1 receptor are abundantly expressed the kidney cells.We have recently found that DPP-4 inhibitors ameliorate vascular injury diabetic rats by blocking harmful effects advanced glycation end products (AGEs).However, how circulating level regulated remain unknown.Methods: We examined anthropometric...
Obesity and the metabolic syndrome (MetS) contribute to endothelial dysfunction (ED). Retinal vessel analysis can identify ED. Obese patients (WHO III°) show ED in retinal vessels which improves with bariatric surgery. To assess determinants of improvement, we used a multiplexed Luminex platform (Myriad-RBM, Austin/Texas) measure serum 261 protein biomarkers, cover numerous pathways for example inflammation, oxidative stress, fat mass Serum samples were obtained before 7 ± 3 months after...
Background: The neuropathic component is present in the mechanism of pain RA 36% cases. presence anxiety-depressive disorders and a decrease quality life patients with are shown. Objectives: study clinical features men women. Methods: group consisted 134 (94 women 40 men), aged 36 to 60 years (average age 48.6 ± 7.1 years) disease duration from 1 year 10 (4.03 1.6 hospitalized rheumatology department Republican Clinical Hospital (Cheboksary). At time inclusion study, all were active stage...
Introduction: It has been shown that face classification software might help distinguishing between subjects with and without acromegaly on regular photographs. In this project we investigated several aspects will be necessary helpful to bring recognition method closer clinical application.