A5062909564- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Temporomandibular Joint Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurogenetic and Muscular Disorders Research
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Health, Environment, Cognitive Aging
- Vestibular and auditory disorders
- Pain Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Complex Systems and Time Series Analysis
- Congenital Anomalies and Fetal Surgery
- Ophthalmology and Visual Impairment Studies
- Visual perception and processing mechanisms
- Botulinum Toxin and Related Neurological Disorders
- RNA modifications and cancer
Sichuan University
2020-2024
West China Second University Hospital of Sichuan University
2023-2024
West China Hospital of Sichuan University
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Abstract Background and Hypothesis Disrupted control of brain state transitions may contribute to the diverse dysfunctions cognition, emotion, behavior that are fundamental schizophrenia. Control theory provides rationale for evaluating from a controllability perspective, which help reveal mechanism clinical features such as cognitive deficits associated with We hypothesized would be altered in patients schizophrenia, networks related symptomatology. Study Design Controllability measurements...
Obsessive-compulsive disorder (OCD) and schizophrenia have distinct but also overlapping symptoms. Few studies examined the shared disorder-specific disturbances in dynamic brain function 2 disorders.
Abstract Background Attention-deficit/hyperactivity disorder (ADHD) is a clinically heterogeneous neurodevelopmental defined by characteristic behavioral and cognitive features. Abnormal brain dynamic functional connectivity (dFC) has been associated with the disorder. The full spectrum of ADHD-related variation dynamics its association features remain to be established. Methods We sought identify patterns linked specific dimensions using sparse canonical correlation analysis across cohort...
Abstract Obsessive–compulsive disorder (OCD) is a debilitating and disabling neuropsychiatric disorder, whose neurobiological basis remains unclear. Although traditional static resting‐state magnetic resonance imaging (rfMRI) studies have found aberrant functional connectivity (FC) in OCD, alterations whole‐brain FC topological properties the context of brain dynamics remain relatively unexplored. The rfMRI data 29 patients with OCD 40 healthy controls were analyzed using group independent...
Studies of dynamic functional connectivity (dFC) and topology can provide novel insights into the neurophysiology brain dysfunction in schizophrenia its relation to core symptoms psychosis. Limited investigations these disturbances have been conducted with never-treated first-episode patients avoid confounds treatment or chronic illness. Therefore, we recruited 95 acutely ill, first-episode, examined dFC patterns relative healthy controls using resting-state magnetic resonance imaging a...
Temporomandibular disorders (TMD) are characterized by sensorimotor and psychological dysfunction, with evidence revealing the implication of a dysfunctional central nervous system. Previous magnetic resonance imaging (MRI) studies have reported brain alterations in TMD, but most focused on either structure or function single modality MRI investigated static functional connectivity (FC) TMD. By combining structural data, present study aimed to identify regions abnormalities TMD patients...
Obsessive-compulsive disorder (OCD) is a disabling neuropsychiatric whose neurobiological basis remains unclear. Magnetic resonance imaging (MRI) studies have reported functional and structural alterations of the anterior cingulate cortex (ACC) in OCD. In this study, we explored activity subregions ACC effective connectivity (EC) between whole brain We used Granger causality analysis (GCA) to identify direction information flow whether impact that was excitatory or inhibitory. performed...
Abstract Tourette syndrome (TS) is a developmental neuropsychiatric disorder characterized by repetitive, stereotyped, involuntary tics, the neurological basis of which remains unclear. Although traditional resting-state MRI (rfMRI) studies have identified abnormal static functional connectivity (FC) in patients with TS, dynamic FC (dFC) relatively unexplored. The rfMRI data 54 children TS and 46 typically developing (TDC) were analyzed using group independent component analysis to obtain...
The fetal period is a critical stage in brain development, and understanding the characteristics of crucial. Although some studies have explored aspects functional networks, few specifically focused on sex differences network characteristics. We adopted graph theory method to calculate connectivity topology properties (including global nodal properties), further compared these parameters between male female fetuses. found that fetuses showed an increased clustering coefficient local...
Children with spinal muscular atrophy (SMA) are at risk of low bone mineral density (BMD) and fragility. This study aims to assess lumbar spine BMD measured by quantitative computed tomography (QCT) investigate influencing factors in children SMA without disease-modifying treatment.
Abstract Tourette syndrome (TS) is a developmental neuropsychiatric disorder characterized by repetitive, stereotyped, involuntary motor and vocal tics, the neurological basis of which remains unclear. Although traditional resting-state MRI (rfMRI) studies have identified abnormal static functional connectivity (FC) in patients with TS, dynamic FC (dFC) relatively unexplored. The rfMRI data 54 children TS 46 typically developing (TDC) were analyzed using group independent component analysis...
Sparse canonical correlation analysis (sCCA) was used to delineate multivariate relationship between dynamic functional connectivity (dFC) and behavior or cognition scores in a cohort of children with without Attention-Deficit/Hyperactivity Disorder (ADHD). We identified four distinct patterns dFC, each corresponded specific dimension (inattention/hyperactivity, somatization) cognitive function (inhibition flexibility, fluency memory). Altered dFC within the default mode network (DMN) DMN...
Temporal dynamics in degree centrality (DC) were measured to detect alterations of dynamic topological organization patients with obsessive-compulsive disorder (OCD) and schizophrenia (SZ). We found both OCD SZ showed decreased occurrence a state manifested as the highest sensory systems. Moreover, we observed common specific alteration temporal variability DC some brain regions, which correlated symptom severity patients, respectively.
Introduction Though schizophrenia (SZ) and obsessive-compulsive disorder (OCD) are conceptualized as distinct clinical entities, they do have notable symptom overlap a tight association. Graph-theoretical analysis of the brain connectome provides more indicators to describe functional organization brain, which may help us understand shared disorder-specific neural basis two disorders. Objectives To explore static dynamic topological OCD SZ well relationship between metrics variables. Methods...
Introduction Obsessive-compulsive disorder (OCD) and schizophrenia (SZ) are both severe psychiatric disorders. Though these two disorders have distinct typical symptoms, there partial polygenic overlap comorbidity between the However, few studies explored shared disorder-specific brain function underlying neural pathophysiology of disorders, especially in aspect dynamics. Objectives To explore abnormal characteristics dynamic functional connectivity (dFC) OCD SZ as well association dFC...