A5071621998- Redox biology and oxidative stress
- Migraine and Headache Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Reproductive System and Pregnancy
- Sulfur Compounds in Biology
- Glutathione Transferases and Polymorphisms
- Mast cells and histamine
- Organ and Tissue Transplantation Research
- Advanced Radiotherapy Techniques
- Genomics, phytochemicals, and oxidative stress
- Chronic Myeloid Leukemia Treatments
- Innovative Teaching Methods
- Lysosomal Storage Disorders Research
- Hereditary Neurological Disorders
- Trigeminal Neuralgia and Treatments
- Fetal and Pediatric Neurological Disorders
- Multiple Myeloma Research and Treatments
- Cerebrospinal fluid and hydrocephalus
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Genetics, Bioinformatics, and Biomedical Research
- RNA regulation and disease
- Per- and polyfluoroalkyl substances research
- Multiple Sclerosis Research Studies
Griffith University
2014-2024
University of Palermo
2019-2024
Ospedale Sacro Cuore Don Calabria
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Queensland Department of Environment and Science
2022
University of Messina
2016
University of Pisa
2016
Catholic University of America
2003-2006
Università Cattolica del Sacro Cuore
1990-2005
Agostino Gemelli University Polyclinic
1996-2004
T lymphocytes are defective in cystine uptake and thus require exogenous thiols for activation function. Here we show that monocyte-derived human dendritic cells (DCs) release cysteine the extracellular space. Cysteine generation is increased by lipopolysaccharide tumor necrosis factor α, contact with specifically recognizing soluble or alloantigens. These stimuli also induce thioredoxin (TRX) accumulation DCs. However, only antigen-specific triggers TRX secretion antigen-presenting cells....
The habituation to sensory stimuli of different modalities is reduced in migraine patients. However, the pain has never been evaluated. Our aim was assess nociceptive pathway function and experimental patients with migraine. Scalp potentials were evoked by CO(2) laser stimulation (laser potentials, LEPs) hand facial skin 24 without aura (MO), 19 chronic tension-type headache (CTTH), 28 control subjects (CS). studied measuring changes LEP amplitudes across three consecutive repetitions 30...
Metastasis is the most life threatening aspect of breast cancer. It a multi-step process involving invasion and migration primary tumor cells with subsequent colonization these at secondary location. The aim present study was to investigate role thioredoxin (Trx1) in cancer assess strength association between high levels Trx1 reductase (TrxR1) expression patient survival. Our results indicate that both TrxR1 are statistically significantly increased compared paired normal tissue from same...
// Prahlad V. Raninga 1,2 , Giovanna Di Trapani 1 Slavica Vuckovic 3 Maneet Bhatia and Kathryn F. Tonissen School of Natural Sciences, Griffith University, Nathan, QLD, Australia 2 Eskitis Institute for Drug Discovery, QIMR Berghofer Medical Research Institute, Brisbane, Correspondence to: Tonissen, email: Keywords : thioredoxin, multiple myeloma, apoptosis, NF-kB, chemoresistance Received February 10, 2015 Accepted March Published April 12, Abstract Multiple myeloma (MM) is a hematological...
Multiple myeloma (MM), the second most common haematological malignancy, is a clonal plasma B-cell neoplasm that forms within bone marrow. Despite recent advancements in treatment, MM remains an incurable disease. Auranofin, linear gold(I) phosphine compound, has previously been shown to exert significant anti-myeloma activity by inhibiting thioredoxin reductase (TrxR) activity. A bis-chelated tetrahedral complex [Au(d2pype)2]Cl (where d2pype 1,2-bis(di-2-pyridylphosphino)ethane) was...
Multiple myeloma (MM) is a B-cell malignancy characterized by an accumulation of abnormal clonal plasma cells in the bone marrow. Introduction proteasome-inhibitor bortezomib has improved MM prognosis and survival; however hypoxia-induced or acquired resistance remains clinical problem. This study highlighted role thioredoxin reductase 1 (TrxR1) MM. Higher TrxR1 gene expression correlated with high-risk disease, adverse overall survival, poor patients. We demonstrated that hypoxia induced...
Multiple myeloma (MM) is characterized by an accumulation of abnormal clonal plasma cells in the bone marrow. Despite recent advancements anti-myeloma therapies, MM remains incurable disease. Antioxidant molecules are upregulated many cancers, correlating with tumor proliferation, survival, and chemoresistance therefore, have been suggested as potential therapeutic targets. This study investigated cross-talk between two antioxidant molecules, thioredoxin reductase (TrxR) heme oxygenase-1...
Prostate re-irradiation is an attractive treatment option in the case of local relapse after previous radiotherapy, either definitive or post-operative setting. In this scenario, introduction MR-linacs may represent a helpful tool to improve accuracy and precision treatment.This study reports preliminary data cohort 22 patients treated with 1.5T MR-Linacs for prostate bed re-irradiation. Toxicity was prospectively assessed collected according CTCAE v5.0. Survival endpoints were measured...
This study was undertaken to investigate the effect of estrogens on histamine release mediated by IgE in rat peritoneal mast cells (PMC) and sensitized human basophils. The were found enhance either PMC basophils upon stimulation with anti-IgE. enhancement dose-dependent reaching maximum value 23% for 41% stimulated anti-IgE preincubation 10<sup>––</sup><sup>8</sup><i>M </i>estrogens. Moreover, when purified used, enhancing still detected, suggesting a...
Different degrees of cerebral calcifications together with encephalofacial angiomatosis and seizure disorder characterize the Sturge-Weber syndrome. According to observations reported in literature, calcium deposits may be found wall vessels, perivascular tissue rarely within neurons. Corresponding variety localizations, interpretation phenomenon remains obscure. Most theories postulate role a vascular factor mesenchymal factor. Ultramicroscopic studies specimens obtained 2 children syndrome...
Primary headaches are closely related to sleep. Modifications in the patterns of arousal during sleep have been reported migraine, especially nights preceding a headache attack. We aimed at evaluating pattern from group patients affected by sleep-related migraine. enrolled 10 consecutive patients, three males and seven females, aged between 20 62 years, who presented frequent attacks migraine without aura (more than five per month), one-half occurred sleep, causing an awakening). A control...
The relationship between maternal hormones and factors secreted by the implanting embryo is still controversial. We have analysed in-vitro effect of oestradiol human embryo-derived histamine-releasing factor (EHRF) on histamine release from rat uterine mast cells. Rat cells which were preincubated with then challenged EHRF gave values two- to threefold higher than those without preincubation. enhancement observed was time- temperature-dependent. A similar obtained sensitized basophils but...
Thioredoxin is a redox active protein which has been implicated in reproductive processes. In this study we investigated the intracellular production and extracellular secretion of placental thioredoxin by human cytotrophoblast cell lines were used as in-vitro model systems. Results clearly demonstrated that not only synthesized these cells but also secreted while present 12 kDa form, it would appear two forms, predominant form accompanied lower amount 10 form. The observed localization...
Cluster headache (CH) is a primary with close relation to sleep. CH presents circa-annual rhythmicity; attacks occur preferably during the night, in rapid eye movement (REM) sleep, and they are associated autonomic neuroendocrine modifications. The posterior hypothalamus key structure for biological phenomenon of CH. Our aim describe 55-year-old man presenting typical episodic CH, whom we performed prolonged sleep study, consisting 9-week actigraphic recording repeated polysomnography,...
The epidemiological, clinical, electrophysiological and nerve biopsy findings of 3 cases n-hexane neuropathy in shoe industry are reported. disease affects more than 1 person working the same environment, regardless their specific role, occurs factories where standards hygiene low. In most severe picture peripheral is associated with symptoms suggesting a concurrent involvement central nervous system such as dysarthria, disproportionate ataxia gait, blurred vision, sometimes, after recovery...