A5059518362- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Collagen: Extraction and Characterization
- Orthopaedic implants and arthroplasty
- Advanced X-ray and CT Imaging
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Neurogenesis and neuroplasticity mechanisms
- Calcium Carbonate Crystallization and Inhibition
- Additive Manufacturing and 3D Printing Technologies
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Advanced MRI Techniques and Applications
- Bone and Dental Protein Studies
- Occupational and environmental lung diseases
- Hydrogels: synthesis, properties, applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Silk-based biomaterials and applications
- Orthopedic Infections and Treatments
- Lung Cancer Treatments and Mutations
- Cellular Mechanics and Interactions
- Mesenchymal stem cell research
- Art Education and Development
- Supramolecular Self-Assembly in Materials
- Marine Biology and Environmental Chemistry
Michigan State University
2008-2025
University of Michigan
2016-2019
Fujifilm (Netherlands)
2017
Ann Arbor Center for Independent Living
2016
University of Cambridge
2014-2015
Axons of the adult central nervous system exhibit an extremely limited ability to regenerate after spinal cord injury. Experimentally generated patterns axon growth are typically disorganized and randomly oriented. Support linear axonal into lesion sites has been demonstrated using arrays uniaxial channels, templated with agarose hydrogel, containing genetically engineered cells that secrete brain-derived neurotrophic factor (BDNF). However, immobilizing factors secreting within a scaffold...
Ice-templating techniques, including freeze-drying and freeze casting, are extremely versatile can be used with a variety of materials systems. The process relies on the freezing water based solution. During freezing, ice nucleates within solution concentrates solute in regions between growing crystals. Once is removed via sublimation, remains porous structure, which negative ice. As final structure solution, variables influence nucleation growth alter ice-templated scaffolds. Nucleation,...
In this paper, we show, for the first time, key link between scaffold architecture and latent heat evolution during production of porous biomedical collagen structures using freeze-drying. Collagen scaffolds are used widely in industry repair reconstruction skeletal tissues organs. Freeze-drying slurries is a standard industrial process, and, until now, literature has sought to characterize influence set processing parameters including freezing protocol weight percentage collagen. However,...
Abstract Longitudinal radiological monitoring of biomedical devices is increasingly important, driven by the risk device failure following implantation. Polymeric are poorly visualized with clinical imaging, hampering efforts to use diagnostic imaging predict and enable intervention. Introducing nanoparticle contrast agents into polymers a potential method for creating radiopaque materials that can be monitored via computed tomography. However, properties composites may altered addition,...
In a previous study, we demonstrated novel manufacturing approach to fabricate multi-channel scaffolds (MCS) for use in spinal cord injuries (SCI). the present extended similar materials processing technology significantly longer (5X) porous poly caprolactone (PCL) MCS and evaluated their efficacy 1 cm sciatic peripheral nerve injury (PNI) model. Due increase dimensions challenges that may arise gap model, microstructural characterization involved wall permeability assess nutrient flow,...
Longitudinally monitoring biomedical devices postimplantation can improve patient outcomes by allowing targeted intervention during healing. Most polymeric are not visible via imaging technologies. Incorporation of nanoparticle contrast agents into polymer matrices creates imageable devices, but understanding and controlling clearance from the implant site after degradation is needed for clinical translation. To achieve homogeneous distribution throughout surface chemistry, particularly...
Linearly growing ultrathin polyelectrolyte multilayer (PEM) films of strong polyelectrolytes, poly(diallyldimethylammonium chloride) (PDAC), and sulfonated polystyrene, sodium salt (SPS) exhibit a gradual shift from cytophilic to cytophobic behavior, with increasing thickness for less than 100 nm. Previous explanations based on film hydration, swelling, changes in the elastic modulus cannot account cytophobicity observed these thin as number bilayers increases. We implemented finite element...
The potential applications of ice-templating porous materials are constantly expanding, especially as scaffolds for tissue engineering. Ice-templating, a process utilizing ice nucleation and growth within an aqueous solution, consists cooling stage (before nucleation) freezing (during formation). While heat release during can change scaffold isotropy, the stage, where crystals grow anneal, determines final size features. To investigate path flow collagen slurries solidification, series molds...
Recombinant peptides have the power to harness inherent biocompatibility of natural macromolecules, while maintaining a defined chemistry for use in tissue engineering. Creating scaffolds from requires stabilization via crosslinking, process known alter both mechanics and density adhesion ligands. The linear recombinant peptide based on human collagen type I (RCP) was investigated after crosslinking. Three treatments were compared: dehydrothermal treatment (DHT), hexamethylene diisocyanate...
Abstract Bleomycin‐induced lung fibrosis is a debilitating disease, linked to high morbidity and mortality in chemotherapy patients. The MRTF/SRF transcription pathway has been proposed as potential therapeutic target, it critical for myofibroblast differentiation, hallmark of fibrosis. In human fibroblasts, the inhibitor, CCG‐257081, effectively decreased mRNA levels downstream genes: smooth muscle actin connective tissue growth factor, with IC 50 s 4 15 μM, respectively. ability CCG‐257081...
Abstract Implanted polymeric devices, designed to encourage tissue regeneration, require porosity. However, characterizing porosity, which affects many functional device properties, is non‐trivial. Computed tomography (CT) a quick, versatile, and non‐destructive way gain 3D structural information, yet various CT technologies, such as benchtop, preclinical clinical systems, all have different capabilities. As system capabilities determine the information that can be obtained, seamless...
3D printed biomaterial implants are revolutionizing personalized medicine for tissue repair, especially in orthopedics. In this study, a radiopaque bismuth oxide (Bi
In recent years, there has been a shift from traditional cell culture on two-dimensional substrates towards the use of three-dimensional scaffolds for tissue engineering. Ice-templating is versatile tool to create porous collagen. Here we discuss specific considerations design moulds produce freeze dried collagen with pore sizes around 100µm, range that relevant A numerical model heat conduction, implemented in COMSOL Multiphysics® version 5.0, calculated temperature contour lines and flow...
Clinical effectiveness of implantable medical devices would be improved with in situ monitoring to ensure device positioning, determine subsequent damage, measure biodegradation, and follow healing. While standard clinical imaging protocols are appropriate for diagnosing disease injury, these have not been vetted devices. This study investigated how radiologists use detect the location integrity implanted whether embedding nanoparticle contrast agents into can improve assessment. To mimic...