Philippe Leclerc

ORCID: 0000-0003-2609-9275
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About
Contact & Profiles
Research Areas
  • Orthopedic Infections and Treatments
  • Orthopaedic implants and arthroplasty
  • Total Knee Arthroplasty Outcomes
  • Personality Disorders and Psychopathology
  • Orthopedic Surgery and Rehabilitation
  • Psychotherapy Techniques and Applications
  • Mental Health and Psychiatry
  • Streptococcal Infections and Treatments
  • Infectious Diseases and Tuberculosis
  • Bone fractures and treatments
  • Shoulder Injury and Treatment
  • Social Sciences and Governance
  • Elbow and Forearm Trauma Treatment
  • Infective Endocarditis Diagnosis and Management
  • Thermal and Kinetic Analysis
  • Personality Traits and Psychology
  • Shoulder and Clavicle Injuries
  • Foot and Ankle Surgery
  • Parasite Biology and Host Interactions
  • Psychopathy, Forensic Psychiatry, Sexual Offending
  • Hip and Femur Fractures
  • Neurogenesis and neuroplasticity mechanisms
  • Microwave-Assisted Synthesis and Applications
  • Reproductive Health and Contraception
  • Trauma Management and Diagnosis

Groupe Hospitalier Diaconesses Croix Saint-Simon
2009-2024

Université de Sherbrooke
2001-2024

Michel-Sarrazin
2022-2023

Université du Québec à Trois-Rivières
2019-2023

Ministry of Health and Social Services
2021

Center for Neurosciences
2021

Assistance Publique – Hôpitaux de Paris
2015-2020

Hôpital Cochin
2015-2020

Université Paris Cité
2020

Délégation Paris 5
2020

The combination of mifepristone (RU 486) and a prostaglandin analogue given either intramuscularly or intravaginally is effective in terminating early pregnancy, but the component regimen cumbersome to administer has side effects. We conducted two studies determine efficacy 600 mg followed by small dose misoprostol, an orally active E1 analogue, for same purpose. In first study, 505 women who had amenorrhea less than 50 days received 400 micrograms misoprostol 48 hours after receiving...

10.1056/nejm199305273282101 article EN New England Journal of Medicine 1993-05-27

Abstract Thermogravimetric analysis (TGA) is a quantitative analytical technique that monitors the mass of sample from 1 mg to several g as furnace ramps temperature high 1600°C under stable or changing gas flow. The first gravimetric test was in 27 BC when Vitruvius measured limestone's change it calcined lime. In modern chemical engineering, researchers apply derive conversions, kinetics, and mechanisms for any process with by isothermal, non‐isothermal, quasi‐isothermal methods. drops...

10.1002/cjce.23673 article EN The Canadian Journal of Chemical Engineering 2019-10-31

Abstract We have previously shown that progesterone (PROG) is synthesized by Schwann cells and promotes myelin formation in the peripheral nervous system (PNS). now report this neurosteroid also stimulates myelination organotypic slice cultures of 7‐day‐old (P7) rat mouse cerebellum. Myelination was evaluated immunofluorescence analysis basic protein (MBP). After 7 days culture (7DIV), we found adding PROG (2–5 × 10 −5 M) to medium caused a fourfold increase MBP expression when compared...

10.1046/j.1471-4159.2003.01881.x article EN Journal of Neurochemistry 2003-07-28

Exchange arthroplasty of one or two stages is required for the treatment chronic periprosthetic joint infections. Two-stage exchange costly and has high morbidity with limited patient mobility between procedures. One-stage been promoted by several European teams as preferred alternative. The aim this study was to prospectively analyze outcome patients a hip infection treated one-stage arthroplasty.We performed prospective cohort in French referral center osteoarticular infections including...

10.2106/jbjs.l.01451 article EN Journal of Bone and Joint Surgery 2014-01-01

In the present study, we report on development and validation of Self Interpersonal Functioning Scale (SIFS), a 24-item self-report questionnaire designed to assess four core elements personality pathology (Identity, Self-direction, Empathy, Intimacy) from DSM-5 Level Personality (LPF) for disorders (PDs).Participants community sample (n = 280) patients specialized treatment facility PDs 106) were included in sample.Overall, SIFS showed sound psychometric properties.A second-order factor...

10.1037/per0000335 article EN Personality Disorders Theory Research and Treatment 2019-04-29

Abstract After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation pseudopregnant rat females (high levels of endogenous progesterone) than males. In addition to intracellular receptors, membrane binding sites hormone such as 25‐Dx may also be involved neuroprotection. present study we investigated distribution membrane‐associated progesterone‐binding protein brain. Immunohistochemical...

10.1111/j.1471-4159.2005.03127.x article EN Journal of Neurochemistry 2005-04-26

Background: The 11th version of the World Health Organization's International Classification Diseases (ICD-11) has adopted a dimensional approach to personality disorder (PD) nosology. Notably, it includes an assessment PD degree severity, which can be classified according five categories. To date, there is no gold standard measure for assessing severity based on ICD-11 model, and are empirically-based anchor points delineate proposed With operationalization degrees in model now being...

10.3389/fpsyt.2021.628057 article EN cc-by Frontiers in Psychiatry 2021-03-18

Abstract Background There have been multiple attempts to try parse out heterogeneity within borderline pathology by identifying patient subtypes; thus far, these works yielded few consistent results. Recent developments in the operationalization of may provide new opportunities identify clinically and conceptually meaningful subgroups patients. The Alternative DSM-5 Model for Personality Disorders (AMPD) offers a categorical-dimensional Borderline personality disorder (BPD) that has yet be...

10.1186/s40479-021-00146-w article EN cc-by Borderline Personality Disorder and Emotion Dysregulation 2021-02-11

10.1016/s0035-1040(06)75930-x article EN Revue de Chirurgie Orthopédique et Réparatrice de l Appareil Moteur 2006-11-01

Abstract Unlike internalizing and externalizing symptoms, psychotic symptoms (e.g., hallucinations, delusions) are manifestations of personality disorders (PDs) that more controversial poorly understood. This leaves clinicians with very little guidance for clinical practice, especially diagnosis. What is more, most reviews have focused strictly on the links between categorically defined borderline PD, which contrasts growing movement emphasizes a dimensional perspective (especially in...

10.1002/jclp.23655 article EN Journal of Clinical Psychology 2024-02-04

The Alternative DSM-5 Model for Personality Disorders (AMPD) retains six specific personality disorders (PDs) that can be diagnosed based on Criterion A level of impairment and B maladaptive facets. Those diagnoses are still underresearched, despite the preference expressed by most PD scholars a mixed/hybrid classification. This study explores possibility using self-report questionnaires to extract AMPD diagnoses. Plausible prevalence estimates were found in three samples (outpatient PD,...

10.1521/pedi_2012_35_541 article EN Journal of Personality Disorders 2022-01-05

Surgical resection of a malignant bone tumor (BT) or soft tissue (STT), with without prosthetic replacement, carries high risk developing postoperative infections. There is limited knowledge on the bacteriological spectrum these postsurgical infections that necessitate empirical antibiotic therapy. The aim this study was to analyze incidence and microbiological features site following BT STT resection. In retrospective mono-center study, we analyzed surgical data all consecutive patients who...

10.1007/s40121-015-0078-6 article EN cc-by-nc Infectious Diseases and Therapy 2015-09-01

Abstract The Alternative Model for Personality Disorders (AMPD), included in the Diagnostic and Statistical Manual of Mental (5th ed.) World Health Organization's International Classification Diseases (11th ed.; ICD‐11) are, respectively, hybrid categorical‐dimensional dimensional frameworks personality disorders (PDs). Both models emphasize dysfunction traits. Previous studies investigating links between AMPD ICD‐11, self‐reported physical aggression have mostly focused on traits did not...

10.1002/pmh.1522 article EN Personality and Mental Health 2021-06-21
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