A5067511913- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Cervical Cancer and HPV Research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Molecular Biology Techniques and Applications
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Hepatitis Viruses Studies and Epidemiology
- Respiratory viral infections research
- Genital Health and Disease
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Vaccine Coverage and Hesitancy
- Bacillus and Francisella bacterial research
- Malaria Research and Control
- COVID-19 epidemiological studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
Chulalongkorn University
2016-2025
King Chulalongkorn Memorial Hospital
2023
Siriraj Hospital
2022
Mahidol University
2022
Ministry of Public Health
2022
Bangkok Metropolitan Administration
2021
Thai Red Cross Society
2021
University of Turku
2018
Due to the common symptoms of COVID-19, patients are similar influenza-like illness. Therefore, detection method would be crucial discriminate between SARS-CoV-2 and influenza virus-infected patients. In this study, CRISPR-Cas12a-based was applied for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), A virus, B virus which a practical attractive application screening with COVID-19 in areas limited resources. The limit SARS-CoV-2, A, 10, 10 3 , copies/reaction, respectively....
Abstract This study monitored the long-term immune response to severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection in patients who had recovered from disease (COVID)-19. Anti-nucleocapsid immunoglobulin G (anti-N IgG) titer serum samples collected at a single (N = 302) or multiple time points 229) 3–12 months after COVID-19 symptom onset SARS-CoV-2 detection specimens was measured by semiquantitative chemiluminescent microparticle immunoassay. The 531 (966 specimens) were...
Between 2018 and 2019, the incidence of chikungunya was approximately 15,000 cases across 60 provinces in Thailand. Here, clinical presentations chikungunya, emergent pattern, genomic diversity virus (CHIKV) causing this massive outbreak were demonstrated. A total 1,806 sera samples from suspected collected 13 Thailand, tested for presence CHIKV RNA, IgG, IgM using real-time PCR, enzyme-linked immunoassay (ELISA), commercial (rapid test). The phylogenetic tree whole-genome E1 constructed...
Understanding antibody responses after natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can guide the disease 2019 (COVID-19) vaccine schedule, especially in resource-limited settings. This study aimed to assess dynamics of SARS-CoV-2 antibodies, including anti-spike protein 1 (S1) immunoglobulin (Ig)G, anti-receptor-binding domain (RBD) total Ig, anti-S1 IgA, and neutralizing against wild-type over time a cohort patients who were previously infected with...
Abstract The growing occurrence of novel recombinants, such as XBB.1.16, has emerged and become predominant, raising concerns about the impact genomic recombination on evolution severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigated molecular epidemiological trends Omicron XBB.1.16 epidemic in Bangkok between December 2022 August 2023. Partial spike complete genome sequencing SARS-CoV-2 samples collected from collaborating hospitals were performed. analysis 491...
The coronavirus 2019 omicron variant has surged rapidly and raises concerns about immune evasion even in individuals with complete vaccination, because it harbors mutations. Here we examine the capability of booster vaccination following CoronaVac/AZD1222 prime to induce neutralizing antibodies (NAbs) against (BA.1 BA.2) T-cell responses. A total 167 participants primed heterologous for 4-5 months were enrolled, receive AZD1222, BNT162b2, or mRNA-1273 as a third dose. Reactogenicity was...
Abstract Seroprevalence studies on SARS-CoV-2 are essential for estimating actual prevalence rates of infection and vaccination in communities. This study evaluated based total anti-nucleocapsid immunoglobulin (N) and/or history. We determined the seroprevalence anti-receptor binding domain (RBD) antibodies across age groups. A cross-sectional was conducted Chonburi province, Thailand, between October 2022 January 2023. Participants included newborns to adults aged up 80 years. All serum...
Viral hepatitis is a global challenge, particularly in low- and middle-income countries. The World Health Organization aims to eliminate HBV HCV by 2030, targeting HBsAg prevalence below 0.1% children under 5. This study analyzed sera from 1,459 participants of all ages Chonburi province, Thailand, between October 2022 January 2023 assess whether this target has been met evaluate the seroprevalence anti-HBs, anti-HBc, anti-hepatitis A virus (HAV), anti-HCV population. Participants were...
Non-bacterial acute gastroenteritis (AGE) associated with virus infection affects individuals living in developing countries, especially children. To investigate whether shedding of certain human enterovirus (EV) is more frequently detected the stool AGE unknown etiology than without symptoms, we tested fecal samples collected from 2,692 diarrhea between January 2010 and December 2016. Samples were for rotavirus, norovirus, EV by reverse-transcription polymerase chain reaction (RT-PCR)...
Abstract The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) is a major global concern. Several SARS-CoV-2 gene mutations have been reported. In the current study associations between variation and exposure history during first wave of outbreak in Thailand January May 2020 were investigated. Forty samples collected at different time points outbreak, parts genome sequence used to assess genomic patterns. phylogenetics 40 clustered into L, GH, GR, O...
Coronavirus disease 2019 (COVID-19) booster vaccination is being comprehensively evaluated globally due to waning immunity and the emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Therefore, this study aimed evaluate antibody responses in individuals vaccinated with two doses BBIBP-CorV vaccine explore boosting effect different platforms BBIBP-CorV-primed healthy adults, including a viral vector (AZD122) mRNA vaccines (BNT162b2 mRNA-1273). The results...
Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic in young children. Therefore, the true rate of is likely underestimated. Few data are available on infections children, and studies SARS-CoV-2 seroprevalence among children during omicron wave limited. We assessed infection-induced estimated associated risk factors for seropositivity. Methods A longitudinal serological survey was conducted from January 2021 through December 2022. The...
Epstein-Barr virus (EBV) is an extremely common herpesvirus that may cause asymptomatic infection or various diseases, including infectious mononucleosis, certain lymphoproliferative diseases and several types of neoplasms. Vaccine development important strategy to reduce the burden EBV-associated timing vaccinations should be before primary occurs. In past, more than 90% Thai children were infected with EBV in early childhood. Now, due improved healthcare system Thailand, we aim determine...
Pornjarim Nilyanimit, M.S., Jira Chansaenroj, Witthaya Poomipak, Kesmanee Praianantathavorn, Sunchai Payungporn, Ph.D., and Yong Poovorawan, M.D.. Ann Lab Med 2018;38:139-46. https://doi.org/10.3343/alm.2018.38.2.139
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although Thailand has been fairly effective at controlling spread of COVID-19, continued surveillance and information on antibody response in recovered patients their close contacts remain necessary absence approved vaccines antivirals. Here, we examined 217 COVID-19 to assess viral RNA shedding residual antibodies against SARS-CoV-2. We also evaluated blood samples from 308...
Abstract Background Efficient monitoring and control of coronavirus disease 2019 (COVID-19) require access to diagnostic tests, serological testing is desirable. In the current study, antibodies were investigated in patients recently diagnosed with severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Methods Cross-sectional data obtained from 245 whom SARS-CoV-2 infection had been confirmed via real-time reverse transcriptase-polymerase chain reaction between March October 2020. Serum...
The SARS-CoV-2 Omicron variant presents numerous mutations potentially able to evade neutralizing antibodies (NAbs) elicited by COVID-19 vaccines. Therefore, this study aimed provide evidence on a heterologous booster strategy overcome the waning immunity against variants.
This study examined the neutralizing activity and receptor-binding domain (RBD) antibody levels against wild-type omicron BA.1 BA.2 variants in individuals who received three doses of COVID-19 vaccination. The relationship between anti-RBD IgG live virus titers was examined. In total, 310 sera samples from after booster vaccination (third-dose) were tested for specific SARS-CoV-2 RBD surrogate neutralization test (sVNT). assay performed using foci-reduction (FRNT50). strongly correlated with...
The Coronavirus disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), continues to surge despite the widespread use of vaccination. In Thailand, more than 77% and 39% population received two doses three COVID-19 vaccines as December 2022, respectively. addition, during Omicron predominant period in 70% Thai individuals have been infected. To gain comprehensive insight into SARS-CoV-2 antibody dynamics following vaccination or infection (hybrid...
SUMMARY Acute haemorrhagic conjunctivitis outbreaks are often attributed to viral infection. In 2014, an unprecedented nationwide outbreak of infectious occurred in Thailand, which affected >300 000 individuals over 3 months. To identify and characterize the virus responsible for epidemic, eye swab specimens from 119 patients were randomly collected five different provinces. Conserved regions enteroviral 5′-UTR adenovirus hexon gene analysed. Enterovirus was identified 71·43% (85/119)...