A5028803558- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Orthopedic Infections and Treatments
- Antifungal resistance and susceptibility
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Nitric Oxide and Endothelin Effects
- Pharmaceutical and Antibiotic Environmental Impacts
- Fungal Infections and Studies
- Vibrio bacteria research studies
- Sarcoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Bone fractures and treatments
- Phytochemicals and Antioxidant Activities
- Total Knee Arthroplasty Outcomes
- Antimicrobial Resistance in Staphylococcus
- Oral and Maxillofacial Pathology
- Malaria Research and Control
- Hormonal Regulation and Hypertension
- Bone Tumor Diagnosis and Treatments
- Peptidase Inhibition and Analysis
- Musculoskeletal synovial abnormalities and treatments
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
Kamineni Institute of Dental Sciences
2025
Motilal Nehru Medical College
2023-2024
Rosalind Franklin Institute
2024
Aligarh Muslim University
2008-2023
Jawaharlal Nehru Medical College Hospital
2007-2023
Arabian Gulf University
2011-2023
Rosalind Franklin University of Medicine and Science
2023
Franklin University
2023
Chicago State University
2018-2022
University of Kota
2021-2022
Highlights•Pancreatic CTCs can be enriched with antigen-agnostic microfluidic technology•Single-cell RNA sequencing of pancreatic reveals three distinct CTC populations•Extracellular matrix genes are highly expressed in mouse and human CTCs•The extracellular protein SPARC contributes to tumor metastasisSummaryCirculating cells (CTCs) shed from primary tumors into the bloodstream, mediating hematogenous spread cancer distant organs. To define their composition, we compared genome-wide...
Glioblastoma (GBM) is thought to be driven by a subpopulation of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity yet remain poorly understood. Here, we present comparative analysis chromatin state in GBM CSCs reveals widespread activation genes normally held check Polycomb repressors. These activated targets include large set developmental transcription factors (TFs) whose coordinated unique the CSCs. We demonstrate critical factor set, ASCL1, activates Wnt...
Objectives: To determine occurrence, prevalence and CTX-M genotypes produced by Enterobacteriaceae from clinical samples three geographically distant Indian hospitals to detect linkage of IS26 with blaCTX-M map its precise insertion position. Methods: A total 130, non-duplicate Escherichia coli Klebsiella pneumoniae resistant a third-generation cephalosporin (3GC) centres were screened for extended-spectrum β-lactamase (ESBL) production using phenotypic detection methods. All isolates...
Background: Indwelling medical devices (IMDs) in critical patients are vulnerable to colonization by biofilm producing bacteria. Complex characteristics of bacterial biofilms promote antibiotic resistance, leading the emergence resistant device-related infections (DRI), which pose new challenges their management. Materials and Methods : The study was done on 135 hospitalized (Intensive care units) pediatric with IMDs (intravascular catheter, urinary endotracheal tube) determine...
Albumin, widely recognized as a highly sensitive and specific marker of hepatocellular carcinoma (HCC), is currently unavailable in the diagnostic laboratory because lack robust platform. In prior study we detected albumin mRNA majority intrahepatic cholangiocarcinomas using novel branched chain RNA situ hybridization (ISH) We now explore utility ISH differentiation HCCs, compare its sensitivity with Hep Par 1 Arginase-1. evaluated 93 HCCs mimics including neuroendocrine tumors...
Tumor necrosis factor-α (TNF-α) has been implicated in the pathogenesis of hypertension and renal injury. However, direct effects TNF-α on hemodynamic excretory function are not yet clearly defined. We examined responses to infusion (0.33 ng·g −1 ·min ) anesthetized mice. Renal blood flow (RBF) glomerular filtration rate (GFR) were determined by PAH inulin clearance. The urine was collected from a cannula inserted into bladder. Following 60-min control clearance period, initiated 15 min...
To date, there is no safe and effective hemoglobin-based oxygen carrier (HBOC) to substitute for erythrocyte transfusion. It uncertain whether a deficiency of endothelial nitric oxide bioavailability (endothelial dysfunction) prevents or augments HBOC-induced vasoconstriction.Hemodynamic effects infusion PolyHeme (1.08 g hemoglobin/kg; Northfield Laboratories, Evanston, IL) murine tetrameric hemoglobin (0.48 hemoglobin/kg) were determined in awake healthy lambs, mice, anesthetized mice. In...
Abstract Background. The objective of this article was to study the role high frequency ultrasound and color Doppler imaging in diagnostic evaluation patients with cervical lymphadenopathy. Methods. present carried out over a period 18 months included 64 different age groups presenting Comprehensive sonographic examination neck for lymph nodes performed using LOGIQ 500 machine (GE Wipro Proseries). scanning patient supine position, hyperextended pad or pillow under shoulders order provide...
Dysfunctional endothelial cell (EC) barrier and increased lung vascular permeability is a cardinal feature of acute injury sepsis that may result in pathophysiological condition characterized by alveolar flooding, pulmonary edema, subsequent hypoxemia. In ECs, activation Rho-associated kinase-1 (ROCK1) phosphorylates myosin light chain (MLC)-associated phosphatase at its inhibitory site, which favors phosphorylation MLC, stress fiber formation, hyperpermeability during injury. The role...
The prominent cultivation of lemongrass relies on the pharmacological incentives its essential oil. oil (LEO) has a significant amount citral (mixture geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, elemol in addition to numerous other bioactive compounds. These components confer various medicinal activities LEO including antifungal, antibacterial, antiviral, anticancer, antioxidant properties. attributes are commercially...
Background: Acute avulsion fractures of the base fifth metatarsal are common and treated in a variety ways. The aims this study were to compare pain, functional outcome, time taken off work after treatment with walking boot or short-leg cast. Methods: Of 39 patients acute metatarsal, 23 cast 16 boot, according preference consultant present at outpatient clinic. Functional outcome was assessed by Visual Analogue Scale Foot Ankle Questionnaire (VAS FA), other complaints on presentation 3, 6,...
Pleomorphic adenoma is the most common salivary gland neoplasm, accounting for a significant proportion of both major and minor tumors. While it frequently arises in parotid or submandibular glands, can occasionally present as an intraoral mass over palate lip when originating from glands. A palatal pleomorphic typically presents painless, gradually enlarging on posterior lateral aspect palate. This article discusses case adenoma, which was successfully managed with surgical excision.
Terrorism in Pakistan remains one of the most significant challenges, deeply impacting nation’s social fabric, political stability, and economic development. In 2024, regions Khyber Pakhtunkhwa (KPK) Islamabad have emerged as critical focal points for terrorist activities, posing severe threats to public safety governance. The country has witnessed a surge targeted attacks, including bomb blasts, armed assaults, suicide missions, primarily orchestrated by resurgent extremist groups. This...
Background The Ilizarov technique has been used in the UK for last 20 years management of infected non-union long bones. This method uses fine wires inserted percutaneously which are attached and tensioned to provide a strong frame construct. majority tibial femoral non unions can be treated successfully by internal fixation. However, an tibia prove difficult problem. useful treating these complex injuries. Objectives To assess whether new limb reconstruction centre comparable results....
The present study was designed to determine resistance rates and patterns in Pseudomonas aeruginosa isolates obtained from hospitalised burn patients an Indian tertiary care hospital. To that end, we isolated plasmid(s) the multidrug-resistant isolates, demonstrated plasmid-mediated by curing transformation experiments, screened all for occurrence of AmpC beta-lactamases. Thirty P. were analysed presence antibiotic resistance. Plasmid-curing experiments beta-lactamase detection performed on...
The present study was conducted to examine the role of nitric oxide (NO), mitochondrial ATP-sensitive K(+) channels (mito K(+)(ATP) channels) and reactive oxygen species (ROS) their interdependence in brief femoral artery ischaemia-induced myocardial preconditioning. To assess injury, infarction induced by occlusion followed reperfusion left anterior descending (LAD) coronary anaesthetized rats assessed triphenyl tetrazolium chloride (TTC) staining. Left ventricular function end-diastolic...
Background The authors investigated whether transfusion with stored erythrocytes would increase tissue injury, inflammation, oxidative stress, and mortality (adverse effects of transfusing erythrocytes) in a murine model hemorrhagic shock. They tested the adverse associated were exacerbated by endothelial dysfunction ameliorated inhaling nitric oxide. Methods studied mice fed high-fat diet (HFD-fed; to induce dysfunction) or standard for 4-6 weeks. Mice subjected 90 min shock, followed...
We reviewed the outcome of patients who had been treated operatively for symptomatic peri-acetabular metastases and present an algorithm to guide treatment. The records 81 between 1987 2010 were identified. There 27 men 54 women with a mean age 61 years (15 87). diagnosis, size lesion, degree pelvic continuity, type reconstruction, World Health Organization performance status, survival time, pain, mobility complications including implant failure recorded in each case. overall patient...
Background:Aflatoxins are a metabolite of Aspergillus molds and widespread in the natural environment. Workers who handle food grains at increased risk exposure to aflatoxins subsequently certain respiratory conditions. In India, more than half employed population is engaged some type agricultural work, yet little known about problems as result among workers India.Objectives:The aim this study was determine occupational food-grain compared not occupationally exposed...