A5000356491- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Renal cell carcinoma treatment
- Chemotherapy-induced organ toxicity mitigation
- Renal Transplantation Outcomes and Treatments
- Cancer Immunotherapy and Biomarkers
- Non-Invasive Vital Sign Monitoring
- Molecular Sensors and Ion Detection
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer Treatment and Pharmacology
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Pharmacological Effects and Toxicity Studies
- Inflammatory mediators and NSAID effects
- Platelet Disorders and Treatments
- Neutropenia and Cancer Infections
- Analytical Chemistry and Chromatography
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Blood groups and transfusion
- Folate and B Vitamins Research
- Pharmacological Receptor Mechanisms and Effects
- Advanced Chemical Sensor Technologies
Oita University Hospital
2019-2025
Genetic factors, inflammatory cytokines such as interleukin (IL)‐6 and tumor necrosis factor‐α (TNF‐α), uremic substances 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF) have been reported to affect organic anion transporting polypeptide (OATP)1B1 transport activity. However, the relationship between OATP1B1 activity these factors in patients with cancer cachexia has not reported. This study aimed identify contributing individual differences cachexia, using coproporphyrin‐I (CP‐I)...
Abstract Combination therapy of tegafur/uracil (UFT) and leucovorin (LV) is widely used to treat colorectal cancers. Although this has a significant therapeutic effect, severe adverse effects occur frequently. Therapeutic drug monitoring (TDM) may help prevent effects. A useful assay that can quantitate plasma levels 5-FU, uracil, tegafur simultaneously for TDM been desired, but such method not currently available. In study, we aimed develop sensitive simultaneous quantification in human...
Background: Lenvatinib is increasingly being selected as the first-line treatment for unresectable hepatocellular carcinoma (HCC) based on results of REFLECT trial. However, early discontinuation lenvatinib because adverse effects a frequent occurrence. Hence, difficult drug use in clinical setting. One causes that dose mainly determined by body weight alone, despite high interindividual variability. To overcome this problem, dosing regimen population pharmacokinetic (PPK) model HCC patients...
Background: Although lenvatinib treatment has a favorable efficacy for unresectable hepatocellular carcinoma (HCC), it is associated with adverse events (AEs) that must be closely monitored and managed. Thrombocytopenia one of the major AEs. The aim this study was to clarify whether thrombocytopenia can predicted by plasma concentration lenvatinib. Methods: This single-center retrospective observational study. Twenty-three patients HCC pharmacokinetics data at initial administration between...
Pazopanib is widely used to treat renal cell carcinomas and soft tissue tumors in Japan. has significant therapeutic efficacy but it associated with frequent severe adverse effects. Therapeutic drug monitoring (TDM) may help prevent A more convenient rapid pazopanib assay desirable for the application of TDM clinical settings. In this study, authors developed a high-throughput method quantifying human plasma using ultra-high-performance liquid chromatography-tandem mass spectrometry...
Clinical cases of attenuation opioid analgesic effect by administration immune checkpoint inhibitors has not been reported. We present a case head and neck cancer under pain management with opioids, in which was exacerbated after nivolumab.A male patient hospitalized for the second-line treatment nivolumab. He had complained admission, but especially worse nivolumab administration. The dose opioids eventually increased approximately 320% (morphine equivalent dose) compared to before...
Background: Affinity chrome-mediated immunoassays (ACMIA) do not require pretreatment and have a wide calibration range good analytical performance. To date, no studies compared ACMIA latex agglutination turbidimetry (LTIA). The objective of this study was to evaluate the interchangeability ACMIA, LTIA, previously developed ultra–high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). Methods: A total 111 whole blood samples were collected from 25 patients...
Abstract Drug‐drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but phenobarbital limited. We describe a case showing increases in plasma as concentrations during preoperative S‐1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer.