A5088316632- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- RNA Research and Splicing
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Schizophrenia research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Metabolism and Genetic Disorders
- Colorectal and Anal Carcinomas
- Tryptophan and brain disorders
- RNA regulation and disease
- Advanced Chemical Sensor Technologies
- Hernia repair and management
- Chemical Thermodynamics and Molecular Structure
- Diet and metabolism studies
- Pleural and Pulmonary Diseases
- Gastroesophageal reflux and treatments
- Renal Diseases and Glomerulopathies
- Mitochondrial Function and Pathology
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Bipolar Disorder and Treatment
Fukui Prefectural University
2024
Shimada Municipal Hospital
2023
Okayama University
2015-2022
Oita Medical Center
2021
Hamamatsu University School of Medicine
2021
Oita University
2001-2020
National Center for Global Health and Medicine
2015-2020
Center for Global Health
2019-2020
Tokyo University of Pharmacy and Life Sciences
2018-2020
Nagoya University
1993-2019
Abstract Ascorbate is an antioxidant and coenzyme for various metabolic reactions in vivo . In plant chloroplasts, high ascorbate levels are required to overcome photoinhibition caused by strong light. However, synthesized the mitochondria molecular mechanisms underlying transport into chloroplasts unknown. Here we show that AtPHT4;4, a member of phosphate transporter 4 family Arabidopsis thaliana , functions as transporter. vitro analysis shows proteoliposomes containing purified AtPHT4;4...
Spinal and bulbar muscular atrophy (SBMA) is a hereditary motor neuron disease caused by the expansion of polyglutamine tract in androgen receptor (AR). Animal studies have shown that pathogenesis SBMA dependent on serum testosterone level. This study aimed at evaluating efficacy safety deprivation leuprorelin acetate patients with SBMA.Fifty underwent subcutaneous injections or placebo randomized, placebo-controlled trial for 48 weeks, followed an open-label additional 96 which 19 group 15...
Spinal and bulbar muscular atrophy (SBMA) is an adult-onset, lower motor neuron disease caused by aberrant elongation of a CAG repeat in the androgen receptor (AR) gene. The main symptoms are weakness bulbar, facial limb muscles, but sensory disturbances frequently found SBMA patients. Motor have been attributed to accumulation mutant AR nucleus neurons, which more profound patients with longer repeat. We examined nerve conduction properties including F-waves total 106 genetically confirmed...
Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. Because progression of SBMA slow, it plausible to identify biomarkers that monitor course for therapeutic development. To verify whether 6-min walk test (6MWT) biomarker SBMA, we performed 6MWT 35 genetically confirmed patients 29 age-matched healthy controls. The distance covered within 6 min (6MWD) was significantly less than controls (323.3 +/-...
Approximately 7% of child patients with inguinal hernias also present cryptorchidism. On the other hand, combined adult cases are uncommon. Here we report two hernia intra-canalicular cryptorchidism who underwent totally extraperitoneal (TEP) repair orchiectomy under same operative view.We treated (49- and 38-year-old men) right indirect Both TEP orchiectomy. In findings, an atrophic testis was drawn out a sac from internal ring. After separated cord structure sheared, it removed. The...
<h3>Objective</h3> Spinal and bulbar muscular atrophy (SBMA) is a lower motor neuron disease caused by the expansion of trinucleotide CAG repeat in androgen receptor (<i>AR</i>) gene. The fundamental histopathological finding this an extensive loss neurons spinal cord brainstem. It is, however, difficult to evaluate clinically degree degeneration, which stresses need for biomarkers detect remaining neuronal function. <h3>Methods</h3> authors performed unit number estimation (MUNE) 52...
Background and Objectives Clinicopathologic features the choice of surgical treatment for mixed hepatocellular cholangiocellular carcinoma (MHC) remain controversial. Methods We evaluated clinicopathological seven cases MHC (one autopsied six surgically resected cases). MHCs were divided into two classes by reference to macroscopic appearance: four single nodular (SN) type three multinodular (MN) type. Results The mean age patients preoperative level serum alpha-fetoprotein 44.5 years 56,457...
The incidence of Heberden's nodes was determined in three groups Japanese women with different occupations to investigate the role work-load their pathogenesis. School cooks (n = 260), each whom prepared 150 450 lunches daily, pre-school 222), 30 80 and municipal employees 298) underwent physical examination X-ray hand if pathology present. osteoarthritis 19.2% 13.5%, 8.6% 5.4%, 5.9% 2.0% among school cooks, workers, respectively. significantly higher cooks. These findings support concept...
Gastric ulcer healing is delayed in patients with portal hypertension (PHT) and often responds poorly to histamine H(2) blockers. Although proton pump inhibitors are more effective anti-ulcer agents, there little information regarding their efficacy for gastric cases of PHT. Therefore, we investigated the effects a inhibitor, omeprazole, on acetic-acid-induced PHT rats.Animals studied were 80 male Sprague-Dawley rats aged 7 weeks, which half underwent two-staged vein ligation (PHT rats) sham...
Pelizaeus-Merzbacher disease (PMD) is a central nervous system (CNS) demyelinating in human, currently known as prototypic hypomyelinating leukodystrophy 1 (HLD1). The gene responsible for HLD1 encodes proteolipid protein (PLP1), which the major myelin produced by oligodendrocytes. HLD9 an autosomal recessive disorder differing from plp1 gene. hld9 arginyl-tRNA synthetase (RARS), belongs to family of cytoplasmic aminoacyl-tRNA synthetases. Herein we show that HLD9-associated missense...
Abstract Studies in genetically modified mice establish that essential roles of endogenous neuromedin U (NMU) are anorexigenic function and metabolic regulation, indicating NMU is expected to be a potential target for anti-obesity agents. However, central administration experiments rats, inconsistent results have been obtained, the role energy metabolism rats remain unclear. This study aims elucidate rats. We generated knockout (KO) unexpectedly showed no difference body weight, adiposity,...
We studied the effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal lesions in rats comparison with those omeprazole. TU-199 inhibited hog activity its potency was almost equal to that omeprazole (IC50 = 6.2 4.2 microM, respectively). In vivo, basal pylorus-ligated dose-dependent manner (ED50 mg/kg p.o.). fistula rats. (2.5 5 i.d.) also stimulated by histamine, carbachol or tetragastrin. Furthermore, prevented formation water-immersion restraint...
Hypomyelinating leukodystrophy 3 (HLD3), previously characterized as a congenital diseases associated with oligodendrocyte myelination, is increasingly regarded primarily affecting neuronal cells.We used N1E-115 cells the cell model to investigate whether HLD3-associated mutant proteins of cytoplasmic aminoacyl-tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) aggregate in organelles and affect differentiation.292CA frame-shift type harboring two-base (CA) deletion at 292th...
Abstract This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. case is particularly instructive because several typical symptoms are clues to this critical adverse drug reaction.
Charcot-Marie-Tooth (CMT) diseases are genetic neuropathies in the peripheral nervous system (PNS). Type 1 CMT Schwann cells, PNS myelinating glial whereas type 2 axonal neuropathies. In addition, there other types of categories diseases. associated with approximately 100 responsible genes. Taiwanese mutation (Asn71-to-Tyr) alanyl-tRNA synthetase (AARS) 2N disease has been reported to have several pathological effects on properties AARS proteins themselves [1]. Also, some mutations genes...
Abstract Background One of the main causes death in psychiatric patients is cardiovascular diseases which are closely related with lifestyle-related diseases. Psychiatric disorders include schizophrenia and mood disorders, whose symptoms treatment medicines different, suggesting that they might have different metabolic disorders. Thus, we studied differences between Japan. Methods This cross-sectional study was performed from 2015 to 2017. Study participants were 189 Japanese hospitalized...
Abstract Spermatogenesis is one of the most dramatic changes in cell differentiation. Remarkable chromatin condensation nucleus observed animal, plant, and algal sperm. Sperm nuclear basic proteins (SNBPs), such as protamine sperm-specific histone, are involved sperm nucleus. Among brown algae, oogamous Fucales algae have a condensed However, existence SNBPs was unclear. Here, we identified linker histone (histone H1) analyzed their gene expression pattern during spermatogenesis Sargassum...
Abstract Background Laparoscopic surgical approaches, including total extraperitoneal repair (TEP), have been widely accepted for inguinal hernia in Japan. However, there are limited data regarding recurrence after TEP Japan, given the versatility of this procedure. This study retrospectively evaluated rates and open mesh at multiple Japanese centers. Methods retrospective 1917 patients who underwent 32 institutions Oita prefecture between January 2014 December 2015. Eligible were grouped...