A5044768974- Hematopoietic Stem Cell Transplantation
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
- Polyomavirus and related diseases
- Acute Myeloid Leukemia Research
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Immune Response and Inflammation
- Hematological disorders and diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Platelet Disorders and Treatments
- Animal Disease Management and Epidemiology
- Blood disorders and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Neutropenia and Cancer Infections
- Cancer Risks and Factors
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Herpesvirus Infections and Treatments
- Antifungal resistance and susceptibility
- Vector-Borne Animal Diseases
- Chemokine receptors and signaling
- Effects and risks of endocrine disrupting chemicals
Oita University Hospital
2012-2024
Oita University
2015-2024
Otsuma Women's University
2004
Kyoto University
1990-2000
Pathological Society
1998
The Japanese Society of Gastroenterological Surgery
1997
Cord blood transplantation (CBT) is a distinct risk factor for human herpesvirus-6 (HHV-6) reactivation and HHV-6 encephalitis. In prospective multicenter trial we investigated the effects of prophylactic foscarnet (90 mg/kg i.v. infusion from days 7 to 27 after CBT) on occurrence reactivation, encephalitis, acute graft-versus-host disease (aGVHD) in CBT recipients. Between 2014 2016, 57 patients were included foscarnet-prophylaxis group. Outcomes compared with an historical control group...
Abstract This multicenter, prospective phase IIb trial evaluating the efficacy and safety of tucidinostat (HBI‐8000) in patients with relapsed or refractory (R/R) adult T‐cell leukemia/lymphoma (ATLL) was undertaken Japan. Eligible had R/R ATLL failed standard care treatment chemotherapy mogamulizumab. Twenty‐three received 40 mg orally twice per week were included analyses. The primary end‐point objective response rate (ORR) assessed by an independent committee. ORR 30.4% (95% confidence...
Abstract TNF-α is implicated in the initiation of cytokine cascades various inflammatory settings. To assess interactions multiple cytokines at level effector cells, we examined effects on expression two IL-8Rs (CXCR1 and CXCR2) polymorphonuclear leukocytes (PMNs). decreased surface CXCR2 a dose- time-dependent manner. In contrast, CXCR1 was not affected by TNF-α. The release into supernatant TNF-α-treated PMNs detected immunoblotting immuno-slot-blot analyses, suggesting that...
We explored the effect of leukotriene B4 (LTB4) on endothelial cells in LTB4-induced transendothelial migration (TEM) neutrophils as an vitro model neutrophil extravasation. Chemotactic response human to LTB4 was significantly lower than that N-formyl-methionyl-leucyl-phenylalanine (fMLP), whereas extent TEM higher fMLP. The study random induced by and fMLP also showed similar results, which indicated might affect umbilical cord vein cell (HUVEC) barrier. Neutrophil pretreatment HUVEC...
Bisphenol A (4, 4'-isopropylinediphenol), an intermediate in the production of polymers and polycarbonates ingredient used plastic dental fillings, is known to be endocrine disruptor. has been shown exert estrogenic effects animals, but its plants were not known. We thus examined whether it phytohormone effects. cytokinin bioassay system that assessed growth soybean (Glycine max cv. 'Acme') calli showed bisphenol stimulated growth, had maximum activity at a concentration 10-1μg ml-1. also...
This prospective multicenter study aimed to determine the effects of human herpesvirus-6B (HHV-6B) reactivation on central nervous system (CNS) function in cord blood transplant (CBT) recipients. Our focus was track HHV-6B and evaluate its association with delirium cognitive function, specifically domains verbal memory, attention/processing speed, quality life (QOL). A cohort 38 patients participated this study. Of 37 evaluated, seven (18.9%) developed delirium, six these cases emerging...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) induced random migration of human polymorphonuclear leukocytes (PMNs) but not chemotaxis. Chemoattractants such as N-formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4), and interleukin-8 (IL-8) both Other inflammatory cytokines, including granulocyte (G-CSF), interleukin 1alpha (IL-1alpha), tumor necrosis alpha (TNF-alpha), did induce either movement. One-minute exposure PMNs to GM-CSF was sufficient for the induction...
Abstract Background Tumor-to-tumor metastasis (TTM) is a rare but well-established phenomenon where histologically distinct tumors metastasize within each other. Here we report the first “known” case of follicular lymphoma that metastasized and extended to mature ovarian teratoma. Case presentation A 59-year-old Japanese postmenopausal woman visited our hospital for detailed examination an tumor. Clinical imaging suggested it be either teratoma-associated cancer with multiple lymph node...
Lymphoblastic lymphoma (LBL) is a rare subtype of non-Hodgkin lymphoma. There are limited reports on allogeneic stem cell transplantation (allo-SCT) in patients with LBL. We retrospectively analyzed the clinical outcomes 15 adult LBL who received allo-SCT at our institution. The median age was 29 years (range, 18-42). Disease status time complete remission (CR), partial (PR), and advanced disease 4, 7 patients, respectively. follow-up duration survivors 25 months 6-106). probabilities...
The pharmacokinetics of voriconazole shows large intra-individual and inter-individual variability is affected by various factors. Recently, inflammation has been focused as a significant factor affecting the variability. This study aimed to compare influence C-reactive protein (CRP) other clinical laboratory parameters on in trough concentration examine impact patients with hematological malignancies. We conducted retrospective, single-center, observational cohort study. Forty-two...
A 59-year-old man with an 18-year history of rheumatoid arthritis who had been treated steroids, methotrexate, and infliximab presented a high-grade fever, cervical lymphadenopathy, hepatosplenomegaly. Epstein-Barr virus (EBV) hepatitis was diagnosed based on the liver histology EBV antibody titer. The symptoms improved temporarily, but five months later, skin rash, jaundice, thrombocytopenia relapsed. Bone marrow biopsies demonstrated infiltration Reed-Sternberg cells. Based these findings,...