A5018474145- Nanoparticle-Based Drug Delivery
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Apelin-related biomedical research
- Neuropeptides and Animal Physiology
- Oral microbiology and periodontitis research
- Amino Acid Enzymes and Metabolism
- Oral and gingival health research
- Advanced Drug Delivery Systems
- Nuclear Receptors and Signaling
- Polyamine Metabolism and Applications
- Hormonal Regulation and Hypertension
- Oral Health Pathology and Treatment
- Asthma and respiratory diseases
- Protein Interaction Studies and Fluorescence Analysis
- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Adenosine and Purinergic Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Metabolism and Genetic Disorders
- Corneal Surgery and Treatments
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Electrospun Nanofibers in Biomedical Applications
Grigore T. Popa University of Medicine and Pharmacy
2008-2023
Yahoo (United Kingdom)
2014
de Duve Institute
2005
Spitalul Clinic de Recuperare
2003
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. TpoR signals by activating Janus kinases JAK2 Tyk2. Here we show that, in addition to signaling downstream from the activated TpoR, Tyk2 strongly promote surface localization enhance total protein levels of TpoR. This effect is caused stabilization mature endoglycosidase H-resistant form receptor. Confocal microscopy indicates that colocalizes partially with...
Apelin (AP), an endogenous ligand of the APJ receptor, is involved in regulation cardiovascular homeostasis. Regardless multiple similarities between AP and angiotensin II (Ang II), their roles seem to be different. We studied both interactions 13 (AP13) Ang what extent, if any, nitric oxide (NO) involved.The experiments were performed endothelium-denuded or endothelium-intact rat portal vein presence 10 µM N(G)-nitro L-arginine methyl ester aminoguanidine. AP13 did not modify isolated tone...
Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether or C4H3F7O), with a molar mass 200.055 g/mol, also called fluoromethyl, is highly fluorinated methyl isopropyl general anesthetic property, available for clinical practice about 30 years. sweet-smelling, non-flammable and it used induction maintenance of anesthesia. Together desflurane, replacing isoflurane halothane in modern anesthesiology. Propofol (2,6-diisopropylphenol C12H18O), 178.271g/mol an alkylphenol...
It has been suggested that tyrosine kinase activity participates in the regulation of signal transduction associated with angiotensin II (Ang II)-induced pharmaco-mechanical coupling rat aortic smooth muscle. We further tested effects genistein, a tyrosine-kinase inhibitor, and its inactive analogue, daidzein, on I I), III III) IV IV) contractions, as compared those Ang II. Genistein partially inhibited II- I-induced contractions. The genistein-induced inhibition was more evident especially...
Angiotensin (1-7) [Ang (1-7)] is a bioactive component of the renin angiotensin system. Ang may interact with type 1 (AT ) or 2 receptors and — specific receptors. We examined interactions between different doses (1nM-1microM) II (Ang II) (10 100nM) on isolated rat portal vein. In endothelium-denuded vein rings, inhibited contractile effects induced by II. The were modified indomethacin, N(G)-nitro-L-arginine methyl ester (L-NAME), (D-Ala 7 )-Angiotensin (H-2888) losartan. Our results...
Our studies aimed the effects of some endoplasmic reticulum stress inducers (thapsigargin, a Ca2+-ATP-ase inhibitor; tunicamycin, protein N-glycosylation brefeldin A, transport paraquat, an enhancer reactive oxygen species production; A23187, Ca2+ ionophore), as well antioxidants (N-acetylcysteine; dithiothreitol, disulfide bond formation inhibitor) on apoptosis cultured rat mesenchymal stem cells. The analyze obtained results evidenced that common and effective herbicide, induced isolated...
Aim of the study The goal our was represented by analysis effects different concentrations platelet-rich plasma extracts on degree senescence dermal fibroblasts (by evaluating β-galactosidase) in presence metformin and rapamycin. Material methods Rat from storage were cultivated using conventional laboratory protocols subsequently assessed for β-galactosidase expression. Then, we used PRP gel a concentration 1% 5%, administered culture medium 5 cell passages. Moreover, pharmacologic active...
The aim of the study was to assess bone gain achieved through guided regeneration (GBR) techniques using bovine-origin xenograft versus porcine-origin combined with autogenous bone. Materials and method. conducted on 62 patients (28 male; 34 female), aged between 40-79 years. All had partial edentulousness were candidates for dental implants rehabilitation resorbed alveolar tissue (GTR) techniques. characteristics groups are presented in Tables 1.1-1.2. Based type graft material used,...
The present studies aimed the effects of tyrphostin AG 494 and 1295 on apoptosis mouse pro-B lymphocytes. actual scientific literature lacks such data. Tyrphostin is an inhibitor epidermal growth factor receptor pathways platelet-derived pathways. Our obtained data demonstrated that was less effective in preventing murine cells, triggered by combination Cytoporone B (NR4A1 agonist) Cyclosporine A. In contrast, had a stronger inhibitory effect same when administered for 24 hours. Thus,...
Abstract One of the most important problems for use liposomes as a drug delivery system is modification vesicle induced by liquid medium in which they are introduced (blood plasma vivo studies and saline buffer solution vitro studies). Using thin‐layer chromatography (TLC) we compared behaviour phosphatidylcholine (used preparation) to that following unfilled liposomes: multilamellar (MLV); small unilamellar vesicles (SUV); reverse phase evaporation (REV), before after storage 15 min...