A5057764298- Protein Degradation and Inhibitors
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Phosphodiesterase function and regulation
- Genomics and Chromatin Dynamics
- Polydiacetylene-based materials and applications
- Ubiquitin and proteasome pathways
University of Colorado Denver
2015-2016
Denver School of Nursing
2016
University of Colorado System
2016
University of Denver
2016
BRD4 governs pathological cardiac gene expression by binding acetylated chromatin, resulting in enhanced RNA polymerase II (Pol II) phosphorylation and transcription elongation. Here, we describe a signal-dependent mechanism for the regulation of cardiomyocytes. is suppressed microRNA-9 (miR-9), which targets 3′ UTR Brd4 transcript. In response to stress stimuli, miR-9 downregulated, leading derepression enrichment at long-range super-enhancers (SEs) associated with genes. A mimic represses...
Self-assembling peptides serve as a versatile tool in stem cell and tissue engineering for advancing next-generation medical therapies.
BRD4 is a member of the BET family proteins, which contain tandem reader domains (bromodomains) that bind to acetylated histone tails within chromatin. We recently demonstrated JQ1, small molecule prevents BRD4-chromatin interaction, potently blocks pathological cardiac hypertrophy and improves function in pre-clinical models. functions as nodal regulator transcriptional program for by recruiting P-TEFb gene regulatory elements, resulting phosphorylation RNA polymerase II (Pol II),...