A5008099375- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Intensive Care Unit Cognitive Disorders
- Cardiac and Coronary Surgery Techniques
- Blood Pressure and Hypertension Studies
- Nosocomial Infections in ICU
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Neonatal Respiratory Health Research
- Hydrogen's biological and therapeutic effects
Tomsk National Research Medical Center
2023-2025
Russian Academy of Sciences
2023-2025
Nosocomial pneumonia is the most common infectious complication following cardiac surgical procedures. The aim was to assess efficacy and safety of repeated inhalation sessions 200 ppm nitric oxide for nosocomial Methods. pilot single-center prospective randomized study included spontaneously breathing patients with cardiovascular diseases, operated on under artificial circulation, a complicated postoperative period in form pneumonia. These ( n = 40) underwent procedures cardiopulmonary...
Objective This study aimed to assess the safety and potential efficacy of high-dose inhaled nitric oxide therapy for prevention postoperative pneumonia in cardiac surgery patients
Background: Postoperative Acute kidney injury (AKI) is a significant concern for cardiac surgery patients with chronic disease (CKD). Effective pharmacological interventions to mitigate these risks are urgently needed. This study aimed evaluate the efficacy and safety of perioperative nitric oxide (NO) administration in preventing AKI limiting CKD progression undergoing surgery. Methods: A total 136 elective cardiopulmonary bypass (CPB) were randomized into two equal groups: NO group (n=68),...
The objective was to study the effect of delivery exogenous nitric oxide on severity apoptosis, pyroptosis, and necroptosis renal parenchyma after simulating cardiopulmonary bypass with circulatory arrest. Materials Methods. 24 Altai breed rams were randomized into 4 equal groups. In CPB CPB+NO groups, we simulated without CPB+CA CPB+CA+NO CPB+NO, NO given perioperative in concentration 80 ppm. CPB, supplied a standard oxygen-air mixture NO. Results . group, TNF-α statistically significantly...
The article describes a clinical case of inhalation therapy with high doses nitric oxide (NO) in comorbid patient severe course COVID-19. An air stream containing NO was generated using the PLAZON device. High-dose administered as life-saving option due to lack effect from treatment delivered accordance current national guidelines for safety and efficacy technique demonstrated.
INTRODUCTION: Acute kidney injury is one of the common complications in cardiosurgical operations with cardiopulmonary bypass (CPB). A number studies have shown that donation exogenous nitric oxide (NO) reduces episodes аcute injury. However, subcellular mechanisms realization nephroprotective properties NO remain unknown. OBJECTIVE: To study safety technology plasma-chemical synthesis and to evaluate effect delivery resulting on mitochondrial damage renal tissue simulation bypass. MATERIALS...
This study aims to determine the effectiveness of administering 80 ppm nitric oxide in reducing kidney injury, mitochondrial dysfunction and regulated cell death kidneys during experimental perfusion. Twenty-four sheep were randomized into four groups: two groups received NO conditioning with 90 min cardiopulmonary bypass (CPB + NO) or CPB hypothermic circulatory arrest CA NO), while sham protocols CA). Kidney injury was assessed using laboratory (neutrophil gelatinase-associated lipocalin,...
INTRODUCTION: Acute kidney injury (AKI) is a common and serious complication after cardiac surgery performed under cardiopulmonary bypass (CPB). Patients with chronic disease (CKD) are particularly vulnerable to surgery-associated AKI. Nitric oxide (NO) has great potential for implementing multi-organ protection in surgery. OBJECTIVES: To test the hypothesis that perioperative nitric conditioning good safety profile reduces incidence of acute during patients disease. MATERIAL AND METHODS: An...
Introduction . Acute kidney injury is a common complication of cardiac surgery with cardiopulmonary bypass. Ischemic-reperfusion injury, systemic inflammation, oxidative stress, and other factors that occur during bypass lead to disruption energy supply death tissue cells. Delivery nitric oxide promising method nephroprotection cardiosurgical operations Aim: To study the parameters renal delivery in experiment. Material Methods. A prospective controlled experimental was performed on 12 rams....
Perioperative management of cardiac surgery leads to significant morphofunctional impairment the lungs, cardiopulmonary bypass (CPB) being principal contributor. The pathophysiological mechanisms associated with include ischaemic-reperfusion injury, oxidative stress and systemic inflammation. Nitric oxide is able limit damage. Aim study: investigate effect nitric supply on state sheep lungs under simulated bypass. Methods. 12 Altai breed were divided into 2 equal groups. Classical techniques...
Introduction: Organoprotective effects of perioperative nitric oxide delivery towards the heart and kidneys have been demonstrated many times in cardiac surgery but information about its ability to prevent respiratory complications is extremely limited. Objective: This study aimed at evaluation efficacy safety for preventing during surgeries involving cardiopulmonary bypass patients with an increased risk adverse events identification factors postoperative acute respiratory. Methods: A...
Introduction: One of the promising areas nephroprotection in cardiac surgery is perioperative nitric oxide donation. The combined using Goal-Directed Perfusion (GDP), Kidney Disease Improving Global Outcomes (KDIGO) and delivery strategies can reduce incidence acute kidney injury by targeting different links pathogenesis injury. Objective: To assess nephroprotective properties combination with KDIGO GDP during cardiopulmonary bypass patients chronic disease.Methods: study included 136...