A5034616571- Astro and Planetary Science
- Ion channel regulation and function
- Planetary Science and Exploration
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Cellular Mechanics and Interactions
- Pharmaceutical Practices and Patient Outcomes
- Isotope Analysis in Ecology
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Plant-based Medicinal Research
- Melanoma and MAPK Pathways
- Chemical Reactions and Isotopes
- Ion Transport and Channel Regulation
- Geology and Paleoclimatology Research
- Cardiac Imaging and Diagnostics
- Respiratory Support and Mechanisms
Tomsk National Research Medical Center
2016-2024
Russian Academy of Sciences
2017-2024
National Research Tomsk State University
2015-2020
Tomsk Polytechnic University
2015-2020
Institute of Cardiology
2015-2018
Siberian State Medical University
1998-2017
Institute of Physics and Technology
2015-2016
Tomsk State University of Control Systems and Radio-Electronics
2014
The Ministry of Education and Science of the Russian Federation
2014
University of Calgary
2009-2012
L-type Ca(2+) channels are broadly expressed in arterial smooth muscle cells, and their voltage-dependent properties important tone development. Recent studies have noted that these not singularly vascular tissue other subtypes likely present. In this study, we ascertained which voltage-gated rat cerebral determined contribution to the myogenic response. mRNA analysis revealed α(1)-subunit of (Ca(v)1.2) T-type (Ca(v)3.1 Ca(v)3.2) present isolated cells. Western blot subsequently confirmed...
This study examined whether elevated intravascular pressure stimulates asynchronous Ca(2+) waves in cerebral arterial smooth muscle cells and if their generation contributes to myogenic tone development. The endothelium was removed from rat arteries, which were then mounted an arteriograph, pressurized (20-100 mmHg) under a variety of experimental conditions. Diameter membrane potential (V(M)) monitored using conventional techniques; wave myosin light chain (MLC(20))/MYPT1 (myosin...
c-Jun N-terminal kinase (JNK) is activated by various brain insults and implicated in neuronal injury triggered reperfusion-induced oxidative stress. Some JNK inhibitors demonstrated neuroprotective potential models, including cerebral ischemia/reperfusion injury. The objective of the present work was to study activity a new specific inhibitor, IQ-1S (11
The intermediate filament protein vimentin has been shown to be required for smooth muscle contraction. adapter p130 Crk-associated substrate (CAS) participates in the signaling processes that regulate force development muscle. However, interaction of filaments with CAS not well elucidated. In present study, ACh stimulation tracheal strips increased ratio soluble insoluble (an index disassembly) association development. activation also induced phosphorylation at Ser 56 as assessed by...
A novel specific inhibitor of c-Jun N-terminal kinase, 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S), has a high affinity to JNK3 compared JNK1/JNK2. The aim this work was study the mechanisms neuroprotective activity IQ-1S in models reversible focal cerebral ischemia (FCI) Wistar rats. animals were administered with an intraperitoneal injection (5 and 25 mg/kg) or citicoline (500 mg/kg). Administration exerted pronounced dose-dependent effect, not inferior effects citicoline....
The tyrosine phosphorylated protein Crk-associated substrate (CAS) has previously been shown to participate in the cellular processes regulating dynamic changes actin architecture and arterial constriction. In present study, treatment of rat mesenteric arteries with phenylephrine (PE) led increase CAS phosphorylation association adapter CrkII. was catalyzed by Abl an vitro study. To determine role kinase vessels, plasmids encoding short hairpin RNA (shRNA) were transduced into chemical...
The objective of this study was to determine whether G(q/11)-coupled receptor activation can enhance the mechanosensitivity a canonical transient potential (TRPC)-like current and consequently myogenic responsiveness rat anterior cerebral arteries. Initial patch-clamp experiments revealed presence basal cation in isolated smooth muscle cells that displayed evidence double rectification, which blocked by trivalent cations (Gd(3+) La(3+)). PCR analysis identified expression TRPC1, 3, 6 7 mRNA...
Control of sympathetic hyperactivity is pivotal for treatment heart failure (HF) in patients with coronary artery disease (CAD). Our earlier studies demonstrated that the auricular pulsed electrical stimulation vagus nerve (VNS) beneficially affected condition CAD HF. The aim our study was to evaluate changes rate (HR) and levels heat shock proteins peripheral blood lymphocytes course VNS.The comprised 70 individuals aged 50-68 years chronic insufficiency, severe left ventricular...