A5040144828- Stochastic processes and financial applications
- Differential Equations and Numerical Methods
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Differential Equations and Boundary Problems
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- Cardiac and Coronary Surgery Techniques
- Intensive Care Unit Cognitive Disorders
- Aortic Disease and Treatment Approaches
- Financial Risk and Volatility Modeling
- Credit Risk and Financial Regulations
- Numerical methods for differential equations
- Acute Kidney Injury Research
- Thermal Regulation in Medicine
- Capital Investment and Risk Analysis
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Nitric Oxide and Endothelin Effects
- Advanced Numerical Methods in Computational Mathematics
- Organ Donation and Transplantation
- Face and Expression Recognition
- Advanced Mathematical Modeling in Engineering
Tomsk National Research Medical Center
2023-2025
Russian Academy of Sciences
2023-2025
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento
2023
Iscte – Instituto Universitário de Lisboa
2017-2022
Performing cardiac surgery under cardiopulmonary bypass (CPB) and circulatory arrest (CA) provokes the development of complications caused by tissue metabolism, microcirculatory disorders, endogenous nitric oxide (NO) deficiency. This study aimed to investigate potential mechanisms for systemic organoprotective effects exogenous NO during CPB CA based on assessment dynamic changes in glycocalyx degradation markers, deformation properties erythrocytes, metabolism experiment. A single-center...
The aim of the study was to evaluate antimicrobial effect single and repeated nitric oxide (NO) exposure on major pathogens nosocomial pneumonia isolated from sputum cardiac surgery patients. Materials Methods. A 24-hour culture microorganisms pan-resistant isolates Pseudomonas aeruginosa , Escherichia coli Acinetobacter baumannii Klebsiella pneumoniae inpatient patients with pneumonia, as well strains P. E. American Type Culture Collection (ATCC), were exposed 200 ppm NO (experimental...
Objective This study aimed to assess the safety and potential efficacy of high-dose inhaled nitric oxide therapy for prevention postoperative pneumonia in cardiac surgery patients
Background: Postoperative Acute kidney injury (AKI) is a significant concern for cardiac surgery patients with chronic disease (CKD). Effective pharmacological interventions to mitigate these risks are urgently needed. This study aimed evaluate the efficacy and safety of perioperative nitric oxide (NO) administration in preventing AKI limiting CKD progression undergoing surgery. Methods: A total 136 elective cardiopulmonary bypass (CPB) were randomized into two equal groups: NO group (n=68),...
The objective was to study the effect of delivery exogenous nitric oxide on severity apoptosis, pyroptosis, and necroptosis renal parenchyma after simulating cardiopulmonary bypass with circulatory arrest. Materials Methods. 24 Altai breed rams were randomized into 4 equal groups. In CPB CPB+NO groups, we simulated without CPB+CA CPB+CA+NO CPB+NO, NO given perioperative in concentration 80 ppm. CPB, supplied a standard oxygen-air mixture NO. Results . group, TNF-α statistically significantly...
Introduction: Surgical interventions under cardiopulmonary bypass and circulatory arrest are complicated by impaired microcirculation in tissues; during hypoxic period the mitochondria dysfunction becomes leading pathogenetic factor of ischemia-reperfusion injuries. In this regard, search for methods organ protection seems to be an extremely urgent task. The using nitric oxide can a promising technique given its pluripotent properties.Objective: study was aimed examining injuries kidney...
INTRODUCTION: Acute kidney injury (AKI) is a common and serious complication after cardiac surgery performed under cardiopulmonary bypass (CPB). Patients with chronic disease (CKD) are particularly vulnerable to surgery-associated AKI. Nitric oxide (NO) has great potential for implementing multi-organ protection in surgery. OBJECTIVES: To test the hypothesis that perioperative nitric conditioning good safety profile reduces incidence of acute during patients disease. MATERIAL AND METHODS: An...
A numerical method for free boundary problems the equation urn:x-wiley:mma:media:mma5483:mma5483-math-0001 is proposed. The based on recent results from transmutation operators theory allowing one to construct efficiently a complete system of solutions above equation, generalizing heat polynomials. corresponding implementation algorithm presented.
This paper develops a novel analytically tractable Neumann series of Bessel functions representation for pricing (and hedging) European-style double barrier knock-out options, which can be applied to the whole class one-dimensional time-homogeneous diffusions, even cases where corresponding transition density is not known. The proposed numerical method shown efficient and simple implement. To illustrate flexibility computational power algorithm, we develop an extended jump default model that...
Perioperative management of cardiac surgery leads to significant morphofunctional impairment the lungs, cardiopulmonary bypass (CPB) being principal contributor. The pathophysiological mechanisms associated with include ischaemic-reperfusion injury, oxidative stress and systemic inflammation. Nitric oxide is able limit damage. Aim study: investigate effect nitric supply on state sheep lungs under simulated bypass. Methods. 12 Altai breed were divided into 2 equal groups. Classical techniques...
Introduction: Organoprotective effects of perioperative nitric oxide delivery towards the heart and kidneys have been demonstrated many times in cardiac surgery but information about its ability to prevent respiratory complications is extremely limited. Objective: This study aimed at evaluation efficacy safety for preventing during surgeries involving cardiopulmonary bypass patients with an increased risk adverse events identification factors postoperative acute respiratory. Methods: A...
Introduction: One of the promising areas nephroprotection in cardiac surgery is perioperative nitric oxide donation. The combined using Goal-Directed Perfusion (GDP), Kidney Disease Improving Global Outcomes (KDIGO) and delivery strategies can reduce incidence acute kidney injury by targeting different links pathogenesis injury. Objective: To assess nephroprotective properties combination with KDIGO GDP during cardiopulmonary bypass patients chronic disease.Methods: study included 136...
Aim . To study the prevalence and risk factors (RF) for hospital-acquired pneumonia (HAP) after on-pump cardiac surgery in a modern cohort of patients. Material methods This retrospective analysis medical records cardiovascular patients, operated on period from January 1, 2022 to December 31, 2022. The consistently included 417 patients who underwent surgery. incidence timing HAP development were assessed. influence main demographic, clinical, perioperative was studied. Results per year...
Abstract This paper uses an analytical framework to examine a firm’s investment and switching strategy under uncertainty. The context is the possibility launch operate two distinct projects, one at time, with exposure stochastic exogenous price. We allow for multiple switches between along abandonment options from each. These possibilities fundamentally influence operational strategy. show that some conditions, dichotomous waiting region may arise stage. In this case we have inaction region,...
Highlights For the first time, incidence and timing of development postoperative pneumonia in patients undergoing surgical reconstruction aortic arch post-covid period were studied. Risk factors for predictors severe course disease this cohort identified. The results obtained will make it possible to differentiate at risk developing from general population targeted perioperative prevention complication. Abstract Aim. To study nosocomial (NP) after surgery, determine impact on its severity...
This paper develops a novel analytically tractable Neumann series of Bessel functions representation for pricing (and hedging) European-style double barrier knock-out options, which can be applied to the whole class one-dimensional time-homogeneous diffusions even cases where corresponding transition density is not known. The proposed numerical method shown efficient and simple implement. To illustrate flexibility computational power algorithm, we develop an extended jump default model that...
A numerical method for free boundary problems the equation \[ u_{xx}-q(x)u=u_t \] is proposed. The based on recent results from transmutation operators theory allowing one to construct efficiently a complete system of solutions this generalizing heat polynomials. corresponding implementation algorithm presented.