A5081337275- Cancer Cells and Metastasis
- Effects of Radiation Exposure
- Biomarkers in Disease Mechanisms
- Immune Cell Function and Interaction
- Vascular Malformations and Hemangiomas
- Digestive system and related health
- Optimism, Hope, and Well-being
- Hematopoietic Stem Cell Transplantation
- Fibroblast Growth Factor Research
- Histiocytic Disorders and Treatments
- Cancer Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Tumors and Oncological Cases
- Mesenchymal stem cell research
- Hydrogen's biological and therapeutic effects
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Pneumocystis jirovecii pneumonia detection and treatment
Naval University of Engineering
2024
Wenzhou Medical University
2022-2024
Hebei General Hospital
2024
Hebei Medical University
2024
Abstract Ionising radiation exposure can lead to acute haematopoietic syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by Food Drug Administration. FG‐4592, as a proline hydroxylase inhibitor, may play an important role radioprotection system. Mice were peritoneal injected FG‐4592 or normal saline. After irradiation, survival time, body weight, peripheral blood cell bone marrow (BMC) count,...
Intestinal tissue is extremely sensitive to ionizing radiation (IR), which easy cause intestinal sickness, and the mortality rate very high after exposure. Recent studies have found that immune cells stem (ISCs) may play a key role in IR-induced injury.
Abstract Background Hematopoiesis have been proved that it could be changed in the patients with advanced cancer. In this study, we investigated changes of HSCs differentiation tumor-bearing mice. Methods The mice model was established by subcutaneously inoculating xenografts B16-F10 mouse melanoma cells into right back male wild-type C57BL/6 Hematopoietic stem and multi-lineage were evaluated using blood routine, HE-staining, flow cytometry assay culture technology. Results exhibited...
Intestinal stem cells (ISCs) are responsible for intestinal tissue homeostasis and important the regeneration of damaged epithelia. Through establishment ionizing radiation (IR) induced injury model, we found that radiosensitivity intestine GSN KO mice increases significantly. It means played a key role in process radiation-induced injury. The deletion aggravated damage decreased survival rate crypts number ISCs after lethal IR vivo. organoid experiments, inhibited proliferation...
Abstract Background: Severe ionizing radiation (IR) induced intestinal injury has high mortality, which is a worldwide problem to be solved urgently. In recent years, studies have found that PHD-HIF signaling pathway may play key roles in IR injury, and we FG-4592, the PHD inhibitor, significant radio-protective effects on injury. Methods: With/without FG4592 treatment, survival time, pathology, cell viability, apoptosis organoids of mice after irradiation were compared, mechanism was...
Background: The incidence of inflammatory bowel disease (IBD) is growing in the population. At present, etiology remains unclear, and there no effective low-toxic therapeutic drug. role PHD-HIF pathway relieving DSS-induced colitis gradually being explored.Methods: Wild-type C57BL/6 mice were used as a model to explore important Roxadustat alleviating colitis. High-throughput RNA-Seq qRT-PCR methods screen verify key differential genes colon between normal saline (NS) groups.Results: could...