A5000224030- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Neonatal Health and Biochemistry
- Urological Disorders and Treatments
- Extracellular vesicles in disease
- Childhood Cancer Survivors' Quality of Life
- Urinary and Genital Oncology Studies
- Hernia repair and management
- Heme Oxygenase-1 and Carbon Monoxide
- Aerospace Engineering and Energy Systems
- Pregnancy and preeclampsia studies
- Pleural and Pulmonary Diseases
- Retinal Diseases and Treatments
- Adenosine and Purinergic Signaling
- Pediatric Urology and Nephrology Studies
- Antioxidant Activity and Oxidative Stress
- Renal Transplantation Outcomes and Treatments
- Inflammasome and immune disorders
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Congenital Heart Disease Studies
- Advanced Glycation End Products research
Hospital for Sick Children
2022-2025
Biologie du Développement et Cellules Souches
2024-2025
Leipzig University
2022-2025
University of Toronto
2024-2025
SickKids Foundation
2024
University Hospital Leipzig
2018
Antenatal administration of extracellular vesicles from amniotic fluid stem cells (AFSC-EVs) reverses features pulmonary hypoplasia in models congenital diaphragmatic hernia (CDH). However, it remains unknown which lung cellular compartments and biological pathways are affected by AFSC-EV therapy. Herein, we conducted single-nucleus RNA sequencing (snRNA-seq) on rat fetal CDH lungs treated with vehicle or AFSC-EVs. We identified that intra-amniotically injected AFSC-EVs reach the rats CDH,...
Abstract Introduction Neonates with lower urinary tract obstruction (LUTO) experience high morbidity and mortality associated the development of chronic kidney disease. The prenatal detection rate for LUTO is less than 50%, late or missed diagnosis leading to delayed management long-term sequelae in remainder. We aimed explore trends at a high-risk fetal center determine if similar postnatal presentations were noted same period. Methods Prenatal databases from tertiary its pediatric between...
Abstract Postnatal pulmonary hypertension is the biggest treatment challenge and major determinant for poor outcome in infants with congenital diaphragmatic hernia (CDH). CDH lungs are hypoplastic exhibit vascular remodeling, whose pathogenesis remains poorly understood. Using a novel micro-static compression system, herein we found that mechanical induces remodeling downregulation of key angiogenic markers rat human fetal lung models, similar features observed autopsy samples. These changes...
Abstract Oligohydramnios (decreased amniotic fluid volume for gestational age) is a severe condition associated with high morbidity and mortality mainly due to fetal pulmonary hypoplasia. Currently, there are limited treatment options promote lung development. Administration of stem cells their derivates have shown promising regenerative properties several neonatal diseases related arrested Herein, we first characterized hypoplasia secondary oligohydramnios in surgical rat model....
Abstract Congenital diaphragmatic hernia (CDH) is a devastating condition characterized by incomplete closure of the diaphragm and herniation abdominal organs into chest. As result, fetuses have pulmonary hypoplasia, whose severity main determinant poor outcome. The pathogenesis hypoplasia secondary to CDH at least in part explained lack or dysregulation miRNAs that are known regulate lung developmental processes. Herein, we report intra-amniotic administration extracellular vesicles derived...
You have accessJournal of UrologyPediatrics IV (MP55)1 May 2024MP55-08 OBESITY IN PEDIATRIC KIDNEY TRANSPLANT PATIENTS IS NOT ASSOCIATED WITH HIGHER RISK OF POSTOPERATIVE COMPLICATIONS—a 10-YEAR SINGLE CENTER EXPERIENCE Franziska Juliane Richter, Fabian Doktor, Mandy Rickard, Priyank Yadav, Michael E. Chua, Joana Dos Santos, Chia Wei Teoh, Jin K. Kim, and Armando J. Lorenzo RichterFranziska Richter , DoktorFabian Doktor RickardMandy Rickard YadavPriyank Yadav ChuaMichael Chua SantosJoana...
Congenital mature teratomas of the umbilical cord are extremely rare. We report on a girl who presented with ruptured omphalocele and 7 cm mass connected to umbilicus, which we resected first day life. Histology revealed teratoma . On 29th life, secondary laparotomy was necessary address associated intestinal malformations (megaduodenum, stenotic small bowel duplication malrotation). After prolonged hospital stay, discharged patient in age-appropriate conditions. Antenatal diagnosis an tumor...