A5042441448- Gut microbiota and health
- Infant Nutrition and Health
- COVID-19 Impact on Reproduction
- Neonatal and Maternal Infections
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Clinical Nutrition and Gastroenterology
- Preterm Birth and Chorioamnionitis
- Gastrointestinal motility and disorders
- Digestive system and related health
- Clostridium difficile and Clostridium perfringens research
- Maternal Mental Health During Pregnancy and Postpartum
- Family and Patient Care in Intensive Care Units
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inhalation and Respiratory Drug Delivery
- Infant Development and Preterm Care
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Nosocomial Infections in ICU
- Neonatal and fetal brain pathology
- Pneumonia and Respiratory Infections
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
- Infant Health and Development
University of Illinois Chicago
2021-2022
Vanderbilt University
2013-2018
Vanderbilt University Medical Center
2012-2018
Nashville Oncology Associates
2014
Objective The objective was to develop non-invasive predictive models for late-onset neonatal sepsis from off-the-shelf medical data and electronic records (EMR). Design used in this study are 299 infants admitted the intensive care unit Monroe Carell Jr. Children's Hospital at Vanderbilt evaluated sepsis. Gold standard diagnostic labels (sepsis negative, culture positive sepsis, negative/clinical sepsis) were assigned based on all laboratory, clinical microbiology available EMR. Only that...
Streptococcus agalactiae, or Group B (GBS), is a gram-positive bacterial pathogen associated with infection during pregnancy and major cause of morbidity mortality in neonates. Infection the extraplacental membranes surrounding developing fetus, condition known as chorioamnionitis, characterized histopathologically by profound infiltration polymorphonuclear cells (PMNs, neutrophils) greatly increases risk for preterm labor, stillbirth neonatal GBS infection. The advent animal models...
Fecal sampling is widely utilized to define small intestinal tissue-level microbial communities in healthy and diseased newborns. However, this approach may lead inaccurate assessments of disease or therapeutics newborns because the assumption that taxa fecal microbiota are representative present throughout gastrointestinal tract. To assess stratification microbes newborn gut evaluate probable shortcoming place tissue sampling, we simultaneously compared mucosa 15 neonates undergoing...
Bacterial DNA has been reported in the placenta and amniotic fluid by several independent groups of investigators. However, it's taxonomic overlap with fetal maternal bacterial different sites poorly characterized. Here, we determined presence intestines placentas mice at gestational day 17 (n = 13). These were compared to newborn 15), (mouth, n 6; vagina, colon, 7; feces, 8), negative controls rule out contamination. The V4 region 16S rRNA gene indicated a pattern intestine similar but...
Mortality and morbidity from SARS-CoV2 (COVID-19) infections in children remains low, including an exceedingly low rate of horizontal vertical transmission. However, unforeseen complications to childhood health have emerged secondary the pandemic. Few studies date examined unintended pandemic newborns infants. In this Commentary, we discuss impact that COVID-19 may on inheritance newborn microbiome its assembly throughout first years life. early stages when transmission was poorly...
Early life microbial colonization is critical for the development of immune system, postnatal growth, and long-term health disease.The dynamic nascent microbiomes children are highly individualized characterized by low bacterial diversity.Any disruptions in can contribute to shifts normal that persist past first 1000 days result intestinal dysbiosis.Here, we focus on microbiome-host interactions during fetal, newborn, infant microbiome development.We summarize roles communities fetal adverse...
Sepsis is a major cause of neonatal mortality and morbidity worldwide. A recent report suggested that murine host defense against infection could be compromised by immunosuppressive CD71(+) erythroid splenocytes. We examined the impact splenocytes on to endotoxin challenge or polymicrobial sepsis characterized circulating (CD235a(+)) cells in human neonates. Adoptive transfer an Ab-mediated reduction did not alter survival challenge. Ex vivo immunosuppression stimulated adult CD11b(+) was...
Necrotizing enterocolitis (NEC) is the most common surgical emergency in preterm infants, and pathogenesis associates with changes fecal microbiome. As samples incompletely represent microbial communities intestinal mucosa, we sought to determine NEC tissue-specific microbiome assess its contribution pathogenesis.We amplified sequenced V1-V3 hypervariable region of bacterial 16S rRNA gene extracted from tissue corresponding 12 patients 14 without NEC. Low quality non-bacterial sequences were...
Abstract Perinatal transmission of COVID-19 is poorly understood and many neonatal intensive care units’ (NICU) policies minimize mother-infant contact to prevent transmission. We present our unit’s approach ways it may impact microbiome acquisition. attended positive mothers’ deliveries from March-August 2020. Delayed cord clamping skin-to-skin were avoided infants admitted the NICU. No parents’ visits allowed discharge was arranged with negative family members. Maternal breast milk...
Objective: The quantity of enteral protein supplementation required by premature infants to optimize growth has not been determined. This study compares the fed current standard intake (3.5 g/kg/day) with those a higher amount (4.0 g/kg/day). Study design: Fifty-two <1500 g and <33 weeks gestational age participated in blinded, single-center, prospective randomized control trial compare between two groups different protein-intake levels. Primary outcomes were average daily weight gain...