A5037578401- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Immune Response and Inflammation
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- GDF15 and Related Biomarkers
- Cancer Treatment and Pharmacology
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Pneumonia and Respiratory Infections
- Gestational Trophoblastic Disease Studies
- Hemoglobin structure and function
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Berberine and alkaloids research
- Cellular Mechanics and Interactions
- Natural Compounds in Disease Treatment
- Lung Cancer Research Studies
- Hydrogen's biological and therapeutic effects
- Cardiac Ischemia and Reperfusion
- Immunotherapy and Immune Responses
- Pain Mechanisms and Treatments
Renmin Hospital of Wuhan University
2021-2022
Wuhan University
2021-2022
Qingdao University
2012-2021
Affiliated Hospital of Qingdao University
2015-2021
The aim of the present study was to investigate protective mechanisms and identify effects isoquercetin on myocardial infarction in a rat model acute (AMI). Isoquercetin ameliorated infarct size, creatine kinase (CK), CK‑MB lactic dehydrogenase activity inhibited inflammation, oxidative stress heart cell apoptosis with AMI. increased endothelial nitric oxide synthase, reduced inducible synthase levels suppressed Toll-like receptor 4‑nuclear factor (TLR4‑NF)‑κB signaling pathway Overall, AMI...
The present study investigated the expression of microRNA (miRNA or miR)‑199a‑5p in peripheral blood patients with primary hypertension, and examined its mechanism action vascular endothelial cell injury induced by hypertension. A total 57 who were treated at Affiliated Hospital Qingdao University (Qingdao, China) between December 2014 November 2015 included study. Peripheral was collected from all patients. miR‑199a‑5p measured using reverse‑transcription quantitative polymerase chain...
BACKGROUND Gut bacterial diversity is decreased in a proportion of patients with septic shock. We attempted to validate the hypothesis that low increases risk mortality. MATERIAL AND METHODS All shock seen at 2 medical center from 2016 through 2019 were included this cohort study. Total DNA was isolated stool, and high-throughput sequencing performed. Clinical data extracted patient records hospital databases. Patients grouped by gut microbiota (measured Shannon index) on presentation. used...
The aim of the present study was to compare expression transcriptional coactivator with PDZ-binding motif (TAZ) in pancreatic cancer (PC) patients, and investigate regulation mechanisms TAZ proliferation PC. PC tissues matched peritumoral tissues, juice serum were collected from patients who underwent pancreatectomy between June 2012 December 2015 at Affiliated Hospital Qingdao University (Qingdao, China). Pancreatic chronic pancreatitis as a control. levels taz mRNA samples examined by...
Atherosclerosis (AS) is the leading cause of cardiovascular disease and poses a threat to human health. MicroRNAs (miRNAs/miRs) are group endogenous small non-coding RNAs that have been identified serve important roles in AS. However, expression role miR-133a-3p AS remains unclear. The aim present study was investigate determine its underlying mechanism. level blood vascular plaque tissue patients with detected via reverse transcription-quantitative PCR (RT-qPCR). smooth muscle cells...
To explore the analgesic effect of dizocine combined with ropivacaine on recurrent neuropathic pain in rat model peripheral nerve compression. Rats were randomly divided into 5 groups: sham control group (S), compression (M), (D), (R), and drug (DR). Rat was constructed to observe symptoms rats before after surgery. Mechanical withdrawal threshold measured 21st day The electrophysiological changes by biopotential recording system, including proximal latency, distal compound muscle action...
Respiratory tract infections in the elderly are difficult to cure and can easily recur, thereby posing a great threat patient prognosis quality of life.To investigate therapeutic effects different antibiotics patients with respiratory infection.Seventy-four infection were randomly allocated study (n = 37; treated cefoperazone sodium/sulbactam sodium) or control piperacillin sodium/tazobactam sodium on basis routine symptomatic support) group. Both groups for 7 d. Time symptom relief...
Severe acute pancreatitis (SAP) usually causes multiple-organ dysfunction syndrome and exhibits a high mortality rate. It has been previously reported that berberine, as dominant alkaloid, can be effectively used against inflammation. However, there is limited data on the effects of berberine hydrochloride (BBRH) inflammation in SAP rat models. Male Sprague–Dawley rats were given preliminary intraperitoneal injections BBRH 30 min prior to retrograde infusion 5% sodium taurocholate their...
Abstract An increasing number of microRNAs (miRs) have been shown to serve crucial roles in intestinal ischemia/reperfusion (II/R) injury. The aim the present study was examine effects miR-129-5p on II/R injury vitro and vivo . It revealed that expression level upregulated, whereas SP-D downregulated tissues I/R mice. Serum levels diamine oxidase, FD-4 D-lactic acid, which are commonly used indicators mucosal permeability, were significantly decreased following knockdown. By contrast, ZO-1...