A5070698572- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- Circular RNAs in diseases
- Additive Manufacturing Materials and Processes
- Concrete and Cement Materials Research
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Molecular Biology Techniques and Applications
- High Entropy Alloys Studies
- Acute Ischemic Stroke Management
- RNA modifications and cancer
- Blood Coagulation and Thrombosis Mechanisms
- Concrete Corrosion and Durability
- High-Temperature Coating Behaviors
- Pancreatic and Hepatic Oncology Research
- Welding Techniques and Residual Stresses
- Viral gastroenteritis research and epidemiology
- NF-κB Signaling Pathways
- Angiogenesis and VEGF in Cancer
- Stochastic processes and statistical mechanics
- Cell Adhesion Molecules Research
- Advanced MRI Techniques and Applications
- Alcohol Consumption and Health Effects
- Hippo pathway signaling and YAP/TAZ
- Peroxisome Proliferator-Activated Receptors
Qingdao University
2017-2024
Affiliated Hospital of Qingdao University
2017-2024
Hebei University of Technology
2024
Xinjiang Production and Construction Corps
2023
Southeast University
2022-2023
Xi'an Jiaotong University
2023
Beijing University of Posts and Telecommunications
2015
Renmin University of China
2015
Background and objective Carotid plaque Crouse score serum homocysteine (Hcy) are closely associated with white matter hyperintensities (WMH). In recent years, it had been found that the pathological mechanism of periventricular WMH (PVWMH) deep subcortical (DSWMH) was different. this study, we aimed to further determine respective effects Hcy on location WMH. Methods We recruited 284 patients lacunar infarction admitted Affiliated Hospital Qingdao University conducted a retrospective cohort...
The aim of the present study was to investigate protective mechanisms and identify effects isoquercetin on myocardial infarction in a rat model acute (AMI). Isoquercetin ameliorated infarct size, creatine kinase (CK), CK‑MB lactic dehydrogenase activity inhibited inflammation, oxidative stress heart cell apoptosis with AMI. increased endothelial nitric oxide synthase, reduced inducible synthase levels suppressed Toll-like receptor 4‑nuclear factor (TLR4‑NF)‑κB signaling pathway Overall, AMI...
The present study investigated the expression of microRNA (miRNA or miR)‑199a‑5p in peripheral blood patients with primary hypertension, and examined its mechanism action vascular endothelial cell injury induced by hypertension. A total 57 who were treated at Affiliated Hospital Qingdao University (Qingdao, China) between December 2014 November 2015 included study. Peripheral was collected from all patients. miR‑199a‑5p measured using reverse‑transcription quantitative polymerase chain...
Red mud is a byproduct of the aluminum oxide refining process that an industrial waste residue. The storage red can seriously contaminate soil, water system, and atmosphere while also taking up lot valuable land resources. However, use stabilized/amended technology in road engineering relatively limited. Consequently, this research investigates how additives (cement, lime, phosphogypsum) affect strength amended as base material. Additionally, it examines effects dry–wet freeze–thaw cycles on...
The aim of the present study was to compare expression transcriptional coactivator with PDZ-binding motif (TAZ) in pancreatic cancer (PC) patients, and investigate regulation mechanisms TAZ proliferation PC. PC tissues matched peritumoral tissues, juice serum were collected from patients who underwent pancreatectomy between June 2012 December 2015 at Affiliated Hospital Qingdao University (Qingdao, China). Pancreatic chronic pancreatitis as a control. levels taz mRNA samples examined by...
Atherosclerosis (AS) is the leading cause of cardiovascular disease and poses a threat to human health. MicroRNAs (miRNAs/miRs) are group endogenous small non-coding RNAs that have been identified serve important roles in AS. However, expression role miR-133a-3p AS remains unclear. The aim present study was investigate determine its underlying mechanism. level blood vascular plaque tissue patients with detected via reverse transcription-quantitative PCR (RT-qPCR). smooth muscle cells...
In terms of the infrastructure construction near coral reefs, native aggregates have been widely implemented as alternative efficient building materials to prepare "coral concrete". This study focused on mechanical properties and hardening mechanism particles under cement-based systems. Firstly, were divided into two categories: biological debris (calcium sand) parent rock (limestone). Subsequently, several elementary laboratory tests conducted compare physical chemical samples. The results...
In a previously published clinical trial, we demonstrated that tirofiban was effective and safe in acute ischemic stroke (AIS) patients who did not undergo early recanalization treatments. We aimed to evaluate neuroimaging characteristics their significance guide treatment. this post hoc analysis, location of infarcts (anterior circulation [ACS] vs. posterior [PCS]), degree cerebral artery stenosis (≤69% ≥70% or occlusion), total infarct volume, ASPECTS were used predict the treatment...
<title>Abstract</title> Background: The dysregulation of sialylation plays a pivotal role in cancer progression and metastasis, impacting various aspects tumor behavior. This study aimed to investigate the prognostic significance long non-coding RNAs (lncRNAs) relation functional pathways Sialic acid-binding immunoglobulin-like lectins (Siglec). Additionally, we develop signature sialylation-related lncRNAs context bladder cancer. Methods: used transcriptomic data clinical information from...
The dysregulation of sialylation plays a pivotal role in cancer progression and metastasis, impacting various aspects tumor behavior. This study aimed to investigate the prognostic significance long non-coding RNAs (lncRNAs) relation sialylation. Additionally, we develop signature sialylation-related lncRNAs context bladder cancer. used transcriptomic data clinical information from TCGA (the Cancer Genome Atlas) database screen for constructed model. relationships between these biological...
Severe acute pancreatitis (SAP) usually causes multiple-organ dysfunction syndrome and exhibits a high mortality rate. It has been previously reported that berberine, as dominant alkaloid, can be effectively used against inflammation. However, there is limited data on the effects of berberine hydrochloride (BBRH) inflammation in SAP rat models. Male Sprague–Dawley rats were given preliminary intraperitoneal injections BBRH 30 min prior to retrograde infusion 5% sodium taurocholate their...
Abstract Our previous trial demonstrated that tirofiban was effective and safe in acute ischemic stroke (AIS) patients who were not undergoing early recanalization treatments. We aimed to further evaluate the structural MRI characteristics their clinical significance better predict guide treatment. In this post hoc analysis of imaging features, location infarcts (anterior circulation [ACS] vs posterior [PCS]), degree cerebral artery stenosis (≤ 69% ≥ 70% or occlusion), total infarct volume...
Excessive intake of Alcohol is associated with a high incidence alcoholic cardiomyopathy (ACM), which may impair cardiac function. In our study, we explored the Abhydrolase Domain Containing 5 (ABHD5) mechanism in ACM about histone deacetylase 4 (HDAC4) and CaM-CaMKII/MEF2 signaling pathway. Rat models were established Wistar rats, vitro cell constructed rat cardiomyocytes H9C2 utilizing 12-h treatment (200 mM) to study regulatory role ABHD5 involvement HDAC4 pathway, as evidenced by...
Objective To analyze the relationship between intraoperative blood loss of transurethral resection prostate (TURP) and micro vascular density (MVD) endothelial growth factor (VEGF). Methods 128 patients who received TURP in our hospital were selected, divided into 3 groups according to volume prostate. Marked vessel depending on types pathology, detected levels VEGF MVD, with hemoglobin colorimetric method, compared pathology classification, MVD VEGF. Results the highest type...