A5101432269- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- Cellular transport and secretion
- Nitric Oxide and Endothelin Effects
- Nanoplatforms for cancer theranostics
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Ubiquitin and proteasome pathways
- Respiratory Support and Mechanisms
- Axon Guidance and Neuronal Signaling
- Sphingolipid Metabolism and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Redox biology and oxidative stress
- Hippo pathway signaling and YAP/TAZ
- Radioactive Decay and Measurement Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Signaling Pathways in Disease
- Inflammasome and immune disorders
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
Seoul National University
2019-2025
Yonsei University
2013-2024
Glutathione (GSH) plays a crucial role in human pathologies. Near-infrared fluorescence-based sensors capable of detecting intracellular GSH vivo would be useful tools to understand the mechanisms diseases. In this work, two cyanine-based fluorescent probes, 1 and 2, containing sulfonamide groups were prepared. Evaluation fluorescence changes displayed by probe 1, which contains 2,4-dinitrobenzenesulfonamide group, shows that it is cell-membrane-permeable can selectively detect thiols such...
Proper regulation of mitophagy for mitochondrial homeostasis is important in various inflammatory diseases. However, the precise mechanisms by which activated to regulate responses remain largely unknown. The NLRP3 (NLR family, pyrin domain containing 3) inflammasome serves as a platform that triggers activation CASP1 (caspase 1) and secretion proinflammatory cytokines. Here, we demonstrate SESN2 (sestrin 2), known stress-inducible protein, suppresses prolonged clearance damaged mitochondria...
The balance between excitatory and inhibitory synaptic inputs, which is governed by multiple synapse organizers, controls neural circuit functions behaviors. Slit- Trk-like proteins (Slitrks) are a family of whose emerging roles incompletely understood. Here, we report that Slitrks enriched in postsynaptic densities rat brains. Overexpression promoted formation, whereas RNAi-mediated knockdown decreased density. Intriguingly, were required for both formation an isoform-dependent manner....
βPix is a guanine nucleotide exchange factor for the Rac1 and Cdc42 small GTPases, which play important roles in dendritic spine morphogenesis by modulating actin cytoskeleton organization. The formation plasticity of spines are essential normal brain function. Among alternatively spliced isoforms, βPix-b βPix-d expressed specifically neurons. Our previous studies using cultured hippocampal neurons identified neurite development, respectively. Here, we analyzed vivo role neuronal isoforms...
Acute lung injury (ALI) induced by excessive hyperoxia has been employed as a model of oxidative stress imitating acute respiratory distress syndrome. Under hyperoxic conditions, overloading quantities reactive oxygen species (ROS) are generated in both epithelial and endothelial cells, leading to ALI. Some NADPH oxidase (NOX) family enzymes responsible for hyperoxia-induced ROS generation cells. However, the molecular mechanisms production type II alveolar cells (AECs) ALI poorly...
Among the biothiols-related diseases, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and can result in severe oxidative stress damage multiple organs. In this study, we aimed develop fluorescence chemosensor that both detect GSH further predict sepsis.
Microtubules are a major cytoskeletal component of neurites, and the regulation microtubule stability is essential for neurite morphogenesis. βPix (ARHGEF7) guanine nucleotide exchange factor small GTPases Rac1 Cdc42, which modulate organization actin filaments microtubules. expressed as alternatively spliced variants, including ubiquitous isoform βPix-a neuronal isoforms βPix-b βPix-d, but function remains unclear. Here, we reveal novel role in regulating tubulin acetylation outgrowth. At...
Axon regeneration is essential for successful recovery after peripheral nerve injury. Although growth cone reformation and axonal extension are crucial steps in regeneration, the regulatory mechanisms underlying these dynamic processes poorly understood. Here, we identify βPix (Arhgef7), guanine nucleotide exchange factor Rac1 GTPase, as a regulator of regeneration. After sciatic injury mice, expression levels increase significantly segments containing regenerating axons. In regrowing axons,...
βPix is a guanine nucleotide exchange factor for the Rho family small GTPases, Rac1 and Cdc42. It known to regulate focal adhesion dynamics cell migration. However,