A5060433056- Parvovirus B19 Infection Studies
- Hemophilia Treatment and Research
- Virology and Viral Diseases
- Dermatological and COVID-19 studies
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Rabies epidemiology and control
- Human Health and Disease
- Erythrocyte Function and Pathophysiology
- Neonatal Health and Biochemistry
- Immune responses and vaccinations
- Neurological Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Syphilis Diagnosis and Treatment
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Mechanical Circulatory Support Devices
- Chronic Myeloid Leukemia Treatments
- Vaccine Coverage and Hesitancy
- Hemostasis and retained surgical items
- Vitamin C and Antioxidants Research
- Aluminum toxicity and tolerance in plants and animals
City Clinical Hospital
2020-2024
Russian Children's Clinical Hospital
2021
Saint Petersburg Pasteur Institute
2000-2018
First Pavlov State Medical University of St. Petersburg
2018
Institut Pasteur
2018
A review of the epidemiology clinical rubella in Perm region Russian Federation from 1979-97 showed that incidence was about 220 cases per 100,000 population. Congenital syndrome (CRS) accounted for 15% birth defects and 3.5 CRS 1000 live births year. Surveys seroepidemiology infection revealed susceptibility rate among pregnant women (i.e. virus antibody haemagglutination-inhibition (HAI) assay titres < 10) 16.5%. As serum HAI > or = 10 both prevented protected their foetuses, serological...
Abstract. The modern data about morphology as well structural and functional organization of the parvovirus B19 genome, circulating virus genotypes are presented in review. Special attention was paid to clinical epidemiological features infection (PVI). Authors focused on distribution PVI different regions Russia own concerning prevalence this North-Western region country including pregnant women – main risk group for PVI. Methods laboratory diagnostics postnatal congenital have been described.
Abstract. Ascorbic acid (vitamin C, AA) is an essential nutrient of the human diet due to its participation on numerous regulatory and enzymatic processes. AA takes part in such vital physiological processes as hormone production, collagen synthesis, stimulation immune system, etc. In present review activities are considered that provide protective effect at influenza infection. This can be result direct virus-inhibiting activity well anti-inflammatory antioxidant properties. Oxidative...
A goal for measles elimination globally by 2010–2020 was recognized as one of the priorities in WHO program “Health All 21st Century” (1998). However outbreaks occurred 2010–2016 countries with high level vaccine coverage including USA and some European countries.Large were also registered on African continent particular Republic Guinea a result decline due to Ebola virus epidemic 2014–2015. recommends carrying out routine vaccination well supplemental immunization activities after stop...
Measles remains one of the main reasons for child mortality in developing countries and periodically leads to emergence large outbreaks different countries. This problem became especially urgent after WHO accepted strategic plan fight against measles. The has set goal decrease measles on a global scale. In 20102011 were registered African continent: Democratic Republic Congo south Africa, Nigeria some other Guinea vaccination is carried out singly children aged 9 months. 20142015 increase...
Parvovirus infection (PVI) is widespread in the world; more than 80% of adult population have antibodies IgG class to parvovirus B19. Malaria a vector-borne parasitic disease caused by protozoa genus Plasmodium, that countries Africa, Southeast Asia, Oceania. The objective present study was evaluate effect B19 on clinical course malaria and outcome underlying disease. During period 2016–2018 blood plasma samples 316 patients from hospital Friya Prefecture Republic Guinea (GR) with confirmed...
The analysis of the results dalteparin sodium (Fragmin®) application for prevention and treatment thrombosis various biodisposition in 62 children has been given. average relative dose depending on age patient, effectiveness drug, s safety; need to select individually controlled doses evaluated.
The drastic decrease of the incidence Measles and Rubella at stage elimination these infections is notified on territory North- Western Federal Region (NWFR) Russia. At same time number cases with error clinical diagnosis increased. most frequent infection caused by Parvovirus (PVI). disease independent particular medical social significance for obstetrics, maternity childhood protection, blood donation service, transplantation organs/tissue etc. aim current study was to estimate prevalence...
Introduction: Prevention of hemorrhagic disease in newborns (HDN) recent years has significantly reduced the number intracranial hemorrhages (ICH) associated with these pathologies and most common etiological cause stroke infants. However, issues intensive therapy for young patients various etiologies didn’t lose their relevance.Objective: Study peculiarities approaches to care children ICH. Material methods: The medical documentation 35 aged 21 days 4 months ICH from 2017 2021 was analyzed....
Wide migration processes typical for megacities, including St. Petersburg, require a comprehensive study of the infection among migrants arriving on work visa. Biological material research was taken from 370 who arrived in Petersburg The control group is represented by 320 adults Petersburg. methodology biological depended type pathogen and included classical modern methods research. All obtained data are processed using adequate mathematical statistics. C. diphtheriae strains migrant...
Hemophilia A presents a serious problem, especially in its severe and inhibitor forms, leading to bleeding complications. The importance of studying the effectiveness safety new treatment approaches, particularly emicizumab, is undeniable for improving quality life patients. Aim: evaluate emicizumab prevention children with forms hemophilia A. Ethical approval was not required since study only involved use generalized retrospective data obtained during routine clinical practice. All were...
Analysis of incidence Rubella in the period 2001–2013 on territory North West Federal Region Russia evidences that large scaled vaccination frames “Public Health” National Project considerably influenced epidemical process rubella virus infection (RVI). However at same time besides drastic decrease to sporadic level (0.4 per 100 000 2013) and limited transmission RVI shift eldest age groups was observed: 94% patients with 2013 were more than 17 years old. Among cases vaccinated consisted...
Surgeries in patients treated prophylactically with emicizumab (including surgical procedures a high risk of postoperative bleeding) are not associated higher risks or technical difficulties compared operations receiving standard replacement therapy. On the contrary, presence blood and its maintenance permanent basic hemostasis allow for reduction doses infusion time bypassing agents. Patients undergoing bleeding require an additional hemostatic treatment during first two three days after...
Thromboses in children represent the serious pathology that can lead to disability and even death of a pediatric patient. At certain localizations thrombosis, most rapid restoration vascular patency (reperfusion) becomes prognostically significant. The accessible method for reperfusion is drug therapy, which injected into patient's blood, its turn significantly accelerates process fibrinolysis, i.e., thrombolytic therapy (TT). purpose this bibliographical review was familiarize physicians,...
Red cell pyruvate kinase deficiency is a rare congenital, nonspherocytic hemolytic anemia caused by glycolytic defect that due to compound heterozygous or homozygous mutations in the PKLR gene on chromosome 1q21. The article presents analytical review of literature and clinical case deficiency. Patient's parents agreed use personal dats photos research publications.
Surgeries in patients treated prophylactically with emicizumab (including surgical procedures a high risk of postoperative bleeding) are not associated higher risks or technical difficulties compared operations receiving standard replacement therapy. On the contrary, presence blood and its maintenance permanent basic hemostasis allow for reduction doses infusion time bypassing agents. Patients undergoing bleeding require an additional hemostatic treatment during first two three days after...
The article presents retrospective data analysis of a cohort patients with PKD (n = 41 patients, aged 4 months – 26,5 years, median age 5 years 1 month) who were examined at the Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology and Immunology for unspecifid hereditary hemolytic anemia during period 2013–2020. study was approved by Independent Ethics Committee Immunology. In all diagnosis confimed Next Generation sequencing (NGS). homozygous mutations in PKLR...