A5047729769- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Diet and metabolism studies
- Aldose Reductase and Taurine
Heidelberg University
2021-2024
University Hospital Heidelberg
2021-2024
Abstract Aim Although of potential biomedical relevance, dipeptide metabolism has hardly been studied. We found the dipeptidase carnosinase‐2 (CN2) to be abundant in human proximal tubules, which regulate water and solute homeostasis. therefore hypothesized, that CN2 a key metabolic role, impacting tubular transport function. Methods A knockout gene ( CNDP2 ‐KO) was generated tubule cells characterized by metabolomics, RNA‐seq analysis, paracellular permeability analysis ion transport....
Amino acids have a central role in cell metabolism, and intracellular changes contribute to the pathogenesis of various diseases, while specific organ distribution dipeptides is largely unknown. We established sensitive, rapid reliable UPLC-MS/MS method for quantification 36 dipeptides. Dipeptide patterns were analyzed brown white adipose tissues, brain, eye, heart, kidney, liver, lung, muscle, sciatic nerve, pancreas, spleen thymus, serum urine C57BL/6N wildtype mice related corresponding...