A5071529537- History and Politics in Latin America
- T-cell and B-cell Immunology
- Economic Theory and Policy
- Immune Cell Function and Interaction
- Conflict, Peace, and Violence in Colombia
- International Relations in Latin America
- Corporate Governance and Law
- Digitalization, Law, and Regulation
- COVID-19 Pandemic Impacts
- Taxation and Legal Issues
- Housing, Finance, and Neoliberalism
- IL-33, ST2, and ILC Pathways
- EU Law and Policy Analysis
- Animal testing and alternatives
- Mitochondrial Function and Pathology
- CAR-T cell therapy research
- Corporate Taxation and Avoidance
- Metabolism and Genetic Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Asthma and respiratory diseases
- International Development and Aid
- Water Governance and Infrastructure
- Monoclonal and Polyclonal Antibodies Research
- Pregnancy and Medication Impact
Otto-von-Guericke University Magdeburg
2022-2024
SOAS University of London
2018-2024
University of London
2018-2024
Universidad de Los Andes
2018-2023
Universidad de Londres
2018-2023
Corporación Internacional para el Desarrollo Educativo
2023
University Hospital Magdeburg
2023
Institute of Medical Microbiology and Hygiene
2005-2022
Technical University of Munich
2002-2022
University of Nebraska–Lincoln
2021
The COVID-19 pandemic has exposed multiple structural flaws of global capitalism. These have been reproduced through the intensification inequalities and reinforced policy responses that failed to protect most vulnerable from health socio-economic impacts COVID-19. also revealed materiality human activity complex geographies inequality. It highlighted how embedded in relations production, reproduction finance continue perpetuate divide between Global North South. Using an interdisciplinary...
A Strep tamer-based k off rate assay identifies T cells with high protective capacity for the adoptive transfer.
MRL/MpJ-Fas(lpr)/J (MRL/lpr) mice represent a well-established mouse model of human systemic lupus erythematosus. MRL/lpr homozygous for the spontaneous lymphoproliferation mutation (lpr) are characterized by autoimmunity, massive lymphadenopathy associated with proliferation aberrant T cells, splenomegaly, hypergammaglobulinemia, arthritis, and fatal immune complex-mediated glomerulonephritis. It was reported previously that steady-state mRNA levels chemokine (C-C motif) receptor 2 (Ccr2)...
dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function poorly understood. Here, we describe the generation characterization dkk3 mutant mice. dkk3-deficient mice are viable fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, most clinical chemistry parameters. Since Dkk3 was proposed to as thyroid hormone binding protein, have analyzed deiodinase activities, well levels. Mutant...
Abstract Background Calcium (Ca 2+ ) signaling regulates various vital cellular functions, including integrin activation and cell migration. Store-operated calcium entry (SOCE) via release-activated (CRAC) channels represents a major pathway for Ca influx from the extracellular space in multiple types. The impact of JAK2-V617F CALR mutations which are disease initiating myeloproliferative neoplasms (MPN) on SOCE, flux endoplasmic reticulum (ER) to cytosol, related key pathways presence or...
Abstract The hegemonic understanding of the green transition will require a massive surge in mineral extraction. We contend that this entails wider, radical shifts 21 st century financialised capitalism. While there has been increasing critical interest role finance capital development, links between finance, extraction, and have largely overlooked. fill gap by arguing transition, understood as transformation global capitalism, is marked new rounds appropriation, exploitation, (re)producing...
It is well documented that sex-dependent factors affect susceptibility to infection, with most mouse models demonstrating higher resistance in females. We made the unexpected observation infection intracellular bacterium Listeria monocytogenes showed an opposite pattern several commonly used inbred strains: female C57BL/6J, BALB/c, C3H/HeN, and CBA/J mice were significantly more susceptible infection. The pronounced sensitivity of females Listeria, which was revealed by lethality rates,...
Many of the academic analyses calling Medellín’s development an “urban miracle” fall short with regard to discussion political economic implications institutional shifts. An emerging transnational capitalist class promoted ‘good governance’ reforms and embedding neoliberalism in urban context. neoliberal agenda is not only a market-led strategy but also particular form hierarchic rule distribution power. Increased activities tertiary sector, promotion flexible labor markets, incorporation...
DNA-binding protein-A (DbpA; gene: Ybx3) belongs to the cold shock protein family with known functions in cell cycling, transcription, translation, and tight junction communication. In chronic nephritis, DbpA is upregulated. However, its activities acute injury models, such as kidney ischemia/reperfusion (IRI), are unclear. To study this, mice harboring Ybx3+/+, Ybx3+/- or Ybx3-/- genotype were characterized over 24 months following experimental IRI. Mitochondrial function, number integrity...
The activating receptor NKG2D recognizes a wide range of different ligands, some which are primarily expressed in “stressed” tissues or on tumor cells. Until now, similar stimulatory effects natural killer and CD8 + T cells have been described for all the receptor/ligand system has therefore interpreted as sensor involved immune surveillance activation responses. We show here that ligands H60 MIC class 1 chain-related protein A (MICA) can also mediate strong suppressive cell proliferation....
The virulence of intracellular pathogens relies largely on the ability to survive and replicate within phagocytes, but also release transfer into new host cells. Such cell-to-cell could represent a target for counteracting microbial pathogenesis. However, our understanding underlying cellular molecular processes remains woefully insufficient. Using intravital 2-photon microscopy caspase-3 activation in Leishmania major (L. major)-infected live skin, we show increased apoptosis cells infected...
This article examines the socioeconomic effects of illegal drug industry on economic and social development in Colombia. It shows that drugs have fostered violence had a negative effect development. also Plan Colombia anti‐drug policy has been an ineffective strategy terms decreasing production, generating reducing violence. Since this study includes both statistical analysis growth Colombia, along with evaluation programme, it fills gap between existing empirical studies Colombian specific analyses
Applying a non-linear political economy analysis of power balances, institutional mechanisms, and elite structures, this study sheds light on the characteristics Medellín’s economic development since early 2000s. Elites with minimal technological capabilities interests in promoting advancement transnational capitalism have successfully secured access to sources power. These conditions (re)produce neoliberal logics local governance that focus growth sectors perceived global comparative...
The COVID-19 pandemic is exposing the vulnerabilities of Latin America's commodity-producing countries and exacerbating their structurally weak position in global financial capitalism. Due to a high dependency on incomes from commodity exports, reliance external finance, volatility exchange rates, economies Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, Peru are hit particularly hard by crisis with projections for 2020 predicting economic contractions up 14 per cent. By looking through...
Abstract By critically reviewing different strands of literature on institutional change and development, this essay argues that, in order to fully understand subnational economic we need move away from ‘good governance' explanations which geography‐specific analyses power structures elite interests are largely absent. Using findings for Colombia insights geography heterodox political economy theories, gives theoretical conceptual guidelines approximations future studies regional...
Abstract T helper (Th) cells provide immunity to pathogens but also contribute detrimental immune responses during allergy and autoimmunity. Th2 mediate asthmatic airway inflammation Th1 are involved in the pathogenesis of multiple sclerosis. cell activation involves complex transcriptional networks metabolic reprogramming, which enable proliferation differentiation into cells. The essential trace element zinc has reported immunomodulatory capacity high concentrations interfere with...
In a large-scale ENU (N-ethyl-N-nitrosourea) mouse mutagenesis programme, we previously have identified and characterized novel mutation Ali18 that causes inflammatory arthritis like lesions in peripheral joints. this study, analysed the immune system of mice to understand mechanisms underlying spontaneous inflammation.Humoral cellular components were phenotyped by ELISA flow cytometry. The contribution for phenotype expression was disease transfer experiments. involvement adaptive...