A5040966095- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Whipple's Disease and Interleukins
- Leprosy Research and Treatment
- IL-33, ST2, and ILC Pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Alcohol Consumption and Health Effects
- Cytokine Signaling Pathways and Interactions
- Hepatitis C virus research
- Immune cells in cancer
- Diverse Scientific Research Studies
- Reproductive System and Pregnancy
- Diagnosis and treatment of tuberculosis
- Hematological disorders and diagnostics
- Immune responses and vaccinations
- Liver Disease Diagnosis and Treatment
- Chemokine receptors and signaling
- interferon and immune responses
Lepra Society
2013-2022
Tanvir Hospital
2018
We studied the factors that regulate IL-23 receptor expression and IL-17 production in human tuberculosis infection. Mycobacterium (M. tb)-stimulated CD4(+) T cells from patients secreted less than did healthy tuberculin reactors (PPD(+) ). M. tb-cultured monocytes PPD(+) donors expressed equal amounts of IL-23p19 mRNA protein, suggesting reduced is not responsible for decreased by patients. Freshly isolated tb-stimulated had phosphorylated STAT3 (pSTAT3) expression, compared with donors....
Previously, we found that pathological immune responses enhance the mortality rate of Mycobacterium tuberculosis (Mtb)-infected mice with type 2 diabetes mellitus (T2DM). In current study, evaluated role cytokine IL-22 (known to play a protective in bacterial infections) and 3 innate lymphoid cells (ILC3s) regulating inflammation Mtb-infected T2DM mice. levels were significantly lower than nondiabetic Similarly, serum (TB) patients TB without T2DM. ILC3s an important source infected Mtb,...
In the current study, we determined effects of interleukin (IL)-21 on human natural killer (NK) cells and monocyte responses during Mycobacterium tuberculosis (Mtb) infection. We found that Mtb stimulated CD4+ NK T from healthy individuals with latent infection (LTBI+) are major sources IL-21. patients secreted less IL-21 than did LTBI+ individuals. Interleukin-21 had no direct effect Mtb-stimulated monocytes. Interleukin-21-activated produced interferon (IFN)-γ, perforin, granzyme B,...
Latent tuberculosis infection (LTBI) is a clinically distinct category of Mycobacterium (Mtb) that needs to be diagnosed at the initial stage. We have reported earlier one Mtb proline-proline-glutamic acid (PPE) proteins, PPE17 (Rv1168c) associated with stronger B-cell and T-cell responses could used diagnose different clinical categories active TB patients higher specificity sensitivity than PPD ESAT-6. Based on these observations we further tested potential for diagnosis LTBI. 198 sera...
Immunological characterization of mycobacterial peptides may help not only in the preparation a vaccine for leprosy but also developing vitro T-cell assays that could perhaps be used as an correlate treatment outcome. The main goal this study was to evaluate use Mycobacterium bovis recombinant 32-kDa protein (r32-kDa) antigen-stimulated assay surrogate marker outcome and monitor vitamin D receptor (VDR)-mediated anti-microbial responses during multidrug therapy (MDT) leprosy.Newly diagnosed...
IL-17 and IL-22 cytokines play an important role in protective immune responses against Mycobacterium tuberculosis (Mtb) infection. Information on the production of these factors that regulate their context human immunodeficiency virus (HIV) latent infection (LTBI) or active disease (ATB) is limited. In current study, we compared two by PBMC HIV-LTBI+ HIV + LTBI+ individuals response to Mtb antigens CFP-10 (culture filtrate protein) ESAT-6 (Early Secretory Antigenic Target). We also...
In the current study, we used a mouse model and human blood samples to determine effects of chronic alcohol consumption on immune responses during Mycobacterium tuberculosis (Mtb) infection. Alcohol increased mortality young mice but not old with Mtb CD11b+Ly6G+ cells are major source IFN-α in lungs Mtb-infected alcohol-fed mice, enhances macrophage necroptosis lungs. Treatment an anti-IFNAR-1 antibody enhanced survival mice. response Mtb, peripheral mononuclear (PBMCs) from alcoholic...
In the current study, we followed 839 household contacts (HHCs) of tuberculosis (TB) patients for 2 years and identified factors that enhanced development TB. Fourteen 17 HHCs who progressed to TB were in 15- 30-year-old age group. At baseline (the "0" time point, when all individuals healthy), concentration thyroid hormone thyroxine (T4) was lower, there increased numbers Tregs PBMCs progressors. baseline, from progressors stimulated with early secretory antigenic target 6 (ESAT-6) 10 kDa...
Purpose Tuberculosis (TB) is the leading cause of infectious disease related mortality, and only 10% infected individuals develop active disease. The likelihood progression latent tuberculosis infection (LTBI) to TB high in HIV individuals. Identification HIV+ at risk would allow treating targeted population, facilitating completion therapy for LTBI prevention development. NK cells have an important role T cell independent immunity against TB, but exact subsets not well characterized....
Interleukin (IL)-1β and IL-2 play important roles in protective immune responses against Mycobacterium tuberculosis (Mtb) infection. Information on the factors that regulate production of these cytokines context human immunodeficiency virus latent infection (LTBI) or active (TB) disease is limited. In this study, we compared by peripheral blood mononuclear cells (PBMCs) from HIV− HIV+ individuals with Tuberculosis response to Mtb Antigen 85A. PBMCs LTBI+ TB patients produced low IL-1β, but...
To determine the mechanisms that mediate resistance to Mycobacterium tuberculosis (M. tuberculosis) infection in household contacts (HHCs) of patients with (TB), we followed 452 latent TB infection-negative (LTBI-) HHCs for 2 years. Those who remained LTBI- throughout study were identified as nonconverters. At baseline, nonconverters had a higher percentage CD14+ and CD3-CD56+CD27+CCR7+ memory-like natural killer (NK) cells. Using whole-transcriptome metabolomic approach, deoxycorticosterone...
In Fig 6B, the boxes in 40X histology images are incorrectly positioned to correspond 100X images.Please see correct 6 below.In S7A and S7B Fig, incorrect representative flow cytometry were used for 5-month T2DM + Mtb group.Please S7 below.
Background TB kills 1.3 million persons annually, including 275,000 people in India. An estimated 40% of the population India has LTBI (Latent Tuberculosis Infection), a significant percentage them being infected with HIV. HIV infection increases likelihood progressing to active TB. Vaccination and immunotherapeutic strategies are alternative approaches that contribute greatly control HIV+ LTBI.
Abstract IL-22 play an important role in protective immune responses against bacterial infections including Mtb and maintains homeostasis by regulating excess inflammation. can also regulate glucose homeostasis, suggesting pathway as a novel target for therapeutic intervention. Previously, we developed mouse model of type 2 diabetes mellitus (T2DM) found that pathological response enhances mortality Mycobacterium tuberculosis (Mtb) infected T2DM mice. In the current study, determined during...
Abstract In the current study, we determined effects of chronic alcohol consumption on mortality young and old mice immune responses during Mycobacterium tuberculosis (Mtb) infection. Eighty percent Mtb H37Rv infected alcohol-fed died in five months compared to twenty-five mice. There is no significant difference lung bacterial burden control diet fed IFN-α levels were significantly higher lungs treatment with anti-IFNAR-1 antibody enhanced their survival. are numbers CD11b+Ly6G+ neutrophils...