A5035646366- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Rheumatoid Arthritis Research and Therapies
- Muscle metabolism and nutrition
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and biological activity of medicinal plants
- Pharmacological Effects of Medicinal Plants
- Biochemical effects in animals
- Essential Oils and Antimicrobial Activity
- Botulinum Toxin and Related Neurological Disorders
- Osteoarthritis Treatment and Mechanisms
- Healthcare and Venom Research
- Pharmacology and Obesity Treatment
- Drug Solubulity and Delivery Systems
- Natural product bioactivities and synthesis
- Ion channel regulation and function
Universidade Federal de Sergipe
2017-2022
Inflammatory arthritis is the most prevalent chronic inflammatory disease worldwide. The pathology of characterized by increased inflammation and oxidative stress, which leads to pain functional loss in joints. Conventional anti-arthritic drugs used relieve other arthritic symptoms often cause severe side effects. α-bisabolol (BIS) a sesquiterpene that exhibits high anti-inflammatory potential significant antinociceptive effect. This study evaluates anti-arthritic, antihyperalgesic effects...
Neuropathic pain (NP) is a difficult condition to treat because of the modest efficacy available drugs. New treatments are required. In study we aimed investigate effects essential oil from Lippia grata alone or complexed in β-cyclodextrin (LG LG-βCD) on persistent inflammatory and neuropathic mouse model. We also investigated Ca2+ currents rat dorsal root ganglion (DRG) neurons. Male Swiss mice were treated with LG LG/β-CD (24 mg/kg, i.g.) their effect was evaluated using an acute pleurisy...
D‐limonene (LIM) is a monocyclic monoterpene with lemon‐like odor and major constituent in several citrus oils (orange, lemon, mandarin, lime, grapefruit). The analgesic profile of LIM has been described previously. However, the short half‐life water insolubility limitation to medicinal uses. So, cyclodextrins, such as β‐cyclodextrin (β‐CD), an important tool minimize these limitations non‐polar compouns, LIM. Now, we assessed anti‐hyperalgesic effect LIM‐β‐CD complexed or alone animal model...
Lippia grata Schauer is a medicinal plant native of the semi‐arid area Northeastern Brazil used in folk medicine as analgesic, anti‐inflammatory and antispasmodic. The leaf essential oil (EO) obtained from L. rich camphor, (E)‐caryophyllene, bicyclogemacrene, camphene borneol which has already demonstrated analgesic profile. pharmacological uses EO could be limited by short half‐life insolubility water but β‐cyclodextrin (CD) an effective tool to improve this. Thus, we assessed profile...