A5103027586- Cervical Cancer and HPV Research
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Marine and coastal plant biology
- Listeria monocytogenes in Food Safety
- Viral Infections and Immunology Research
- Genetic and phenotypic traits in livestock
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Olfactory and Sensory Function Studies
- Essential Oils and Antimicrobial Activity
- Colorectal Cancer Surgical Treatments
- Coastal wetland ecosystem dynamics
- Wildlife Ecology and Conservation
- Bacterial Identification and Susceptibility Testing
- Genital Health and Disease
- Bacterial biofilms and quorum sensing
- Microbial Inactivation Methods
- Travel-related health issues
- COVID-19 and healthcare impacts
- Diabetes Management and Education
- Environmental and Social Impact Assessments
- Risk Perception and Management
- Enterobacteriaceae and Cronobacter Research
- Cancer Risks and Factors
University of Sassari
2010-2024
Azienda Ospedaliero Universitaria di Sassari
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021
University of Pavia
2021
Sapienza University of Rome
2008
Olfactory dysfunction represents one of the most frequent symptoms coronavirus disease 2019, affecting about 70 per cent patients. However, pathogenesis olfactory in 2019 has not yet been elucidated.This report presents radiological and histopathological findings a patient who presented with anosmia persisting for more than three months after infection severe acute respiratory syndrome coronavirus-2.The biopsy demonstrated significant disruption epithelium. This shifts focus away from...
Background: Given the diagnostic accuracy of HPV-DNA tests in terms self-collected samples, order to implement self-sampling cervical screening programs, standardization pre-analytical phase, including decisions concerning choice medium, volume elution, and storage conditions, are necessary, addition understanding potential factors involved acceptability by women. On this basis, we carried out a cross-sectional study assess (i) stability dry vaginal samples stored at room temperature for up...
The aim of the work is to evaluate effectiveness risk communication strategies in cases unsafe drinking water supply Sardinia, Italian context with highest population distrust safety. During period 2010⁻2015, ordinances published on institutional websites were analyzed, and perception was evaluated by applying, for first time public health threats, "OUTRAGE Prediction & Management" software released Sandman. Overall, 417 issued Sardinian Municipalities found. Only 1.5% reported...
Abstract Background This study compared patients undergoing colorectal cancer surgery in 20 hospitals of northern Italy 2019 versus 2020, order to evaluate whether COVID-19-related delays screening resulted more advanced cancers at diagnosis and worse clinical outcomes. Method was a retrospective multicentre cohort analysis March December 2020. Independent predictors disease stage (oncological stage, associated symptoms, T4 metastasis) outcome (surgical complications, palliative surgery,...
Prevention of diabetes mellitus is mainly based on a healthy lifestyle. The lockdown measures imposed during the COVID-19 pandemic resulted in major changes daily life and social behavior, which may have an influence self-management glycemic control. present work aims to assess relationship between diabetic patients’ knowledge, attitudes, behaviors towards proper nutrition lifestyles order plan strategies for educational intervention from health literacy perspective. Attitudes, behaviors,...
HPV infection is a clear etiopathogenetic factor in oropharyngeal carcinogenesis and associated with markedly better prognosis than smoking- alcohol-associated cases, as specified by AJCC classification. The aim of the present work to evaluate prevalence HPV-induced OPSCC an insular area Mediterranean assess reliability p16 IHC (immunohistochemistry) alone, accepted AJCC, diagnosis HPV-driven such setting. All patients consecutively managed referral center North Sardinia head neck tumor...
The aim of this study was to evaluate the correlations between severity and duration olfactory dysfunctions (OD), assessed with psychophysical tests, viral load on rhino-pharyngeal swab determined a direct method, in patients affected by coronavirus disease 2019 (COVID-19).Prospective cohort study.Patients underwent assessment Connecticut Chemosensory Clinical Research Center test determination normalized nasopharyngeal within 10 days clinical onset COVID-19.Sixty COVID-19 were included...
Epigenetic biomarkers in cancer have emerged as promising tools for early detection, prognosis, and treatment response prediction. In cervical cells, hypermethylation of the host viral HPV-genome increases with severity lesions, providing a useful biomarker triage hr-HPV-positive women during treatment. The present study focuses on evaluating clinical performance FAM19A4/miR124-2 methylation test population-based screening program. Previously collected samples, after bisulfite-converted DNA,...
The assessment of human papillomavirus (HPV) genotype dynamics could support the adoption more tailored preventive actions against cervical cancer. aim study was to describe prevalence HPV infection, distribution, and epidemiological characteristics women with ASC-US cytology since introduction HPV-DNA testing in Sardinia (Italy), (March 2016-December 2020). Specimens were tested by RT-PCR for 14 high-risk genotypes. A total 1186 patients enrolled, a median (IQR) age 41 (38-48) years. Of...
Abstract Human‐dominated environments are growing worldwide, forcing animals to adapt new conditions characterized by increased risks and/or anthropogenic resources availability. While numerous studies have compared behavioural patterns of rural and urban populations, little is known about plastic responses temporal variations in human presence. We modelled the behaviour‐specific resource selection 15 wild boars ( Sus scrofa ) GPS‐tracked between 2017 2019 a tourist area Italy high seasonal...
Background: Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) is endemic globally, causing severe infections in hospitalized patients. Surveillance programs help monitor and promptly identify the emergence of new clones. We reported rapid spread a novel clone K. co-harbouring class A D carbapenemases colonized patients, potential risk factors involved development infections. Methods: Rectal swabs were used for microbiological analyses detection most common carbapenemase encoding genes by...
Listeriosis is a foodborne disease characterized by high hospitalization and fatality rates, especially in vulnerable groups including elderly subjects, pregnant women, etc. We report on the first case of Listeria monocytogenes ST-219 meningo-encephalitis woman aged 83 years. An epidemiological molecular investigation was performed to detect source infection virulence factors associated with L. invasiveness this patient. All environmental- clinical-associated isolates were found belong...
Abstract Background Preliminary studies suggest that moderate ARDS and acute renal failure might benefit from extracorporeal CO 2 removal (ECCO R) coupled with CRRT. However, evidence is limited potential for this treatment may need to be explored. The aim of the present study was evaluate whether a protective driving pressure obtained applying low-flow ECCO 2- R plus CRRT in patients affected by COVID-19 compared an historical group without COVID-19. Methods A case-control has been...
Background: Whole-genome sequencing (WGS) provides important information for the characterization, surveillance, and monitoring of antimicrobial resistance (AMR) determinants, particularly in cases multi- extensively drug-resistant microorganisms. We reported results a WGS analysis carried out on carbapenemases-producing Klebsiella pneumoniae, which causes hospital-acquired infections (HAIs) is characterized by marked profile. Methods: Clinical, phenotypic, genotypic data were collected AMR...
Laryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice almost inevitable. We report the case patient with adult onset recurrent LP, showing moderate dysplasia coinfection HPV types 6 18. The tetravalent vaccine Gardasil was prescribed off label, aim triggering an immunogenic response consequently reducing probability further recurrences. followed for 9 months no sign relapse his...
Common variants of genes involved in DNA damage correction [tumor protein p53 (TP53), murine double 2 homolog oncoprotein (MDM2) and ataxia-telengiectasia mutated (ATM)] may serve a role cancer predisposition. The purpose the present study was to investigate association five these with breast risk clinicopathological traits cohort 261 women from northern Sardinia. Polymorphic TP53 (rs17878362, rs1042522 rs1625895), MDM2 (rs2279744) ATM (rs1799757) were determined by PCR TaqMan single...
Hereby, the partial Viral Protein 1 sequences of Coxsackievirus B5 (CV-B5) from sewage samples, collected in Italy 2016 to 2017, were compared with those available GenBank clinical samples. Phylogenetic analysis highlighted: (I) predominant circulation CV-B5 genogroup B Italy, and (II) presence two new sub-genogroups.