A5022101283- Flavonoids in Medical Research
- Bioactive Natural Diterpenoids Research
- RNA Interference and Gene Delivery
- Phytochemistry and Biological Activities
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Reproductive System and Pregnancy
- Cell death mechanisms and regulation
- Quinazolinone synthesis and applications
- Phytochemistry and Bioactive Compounds
- Advanced biosensing and bioanalysis techniques
- Animal health and immunology
- Reproductive tract infections research
- Digital Storytelling and Education
- Autoimmune and Inflammatory Disorders Research
- Sphingolipid Metabolism and Signaling
- Glycosylation and Glycoproteins Research
- Innovative Teaching Methods
- Helicobacter pylori-related gastroenterology studies
- interferon and immune responses
- Antimicrobial Peptides and Activities
- Silymarin and Mushroom Poisoning
- Cervical Cancer and HPV Research
Nanchang University
2011-2021
Jiangxi Provincial Academy of Medical Sciences
2014-2018
Yichun University
2007
First Affiliated Hospital of Jiangxi Medical College
2002
These experiments were employed to explore the mechanisms underlying baicalin action on Candida albicans. We detected inhibition effects three isotope-labeled precursors of 3H-UdR, 3H-TdR and 3H-leucine incorporation into C. albicans using isotope technology. The activities Succinate Dehydrogenase (SDH), cytochrome oxidase (CCO) Ca2+–Mg2+ ATPase, cytosolic Ca2+ concentration, cell cycle apoptosis, as well ultrastructure also tested. found that inhibited (P < 0.005). SDH ATPase in groups...
The activity of negative immune regulatory molecules, such as indoleamine 2,3‐oxygenase (IDO), significantly attenuates DC (Dendritic cells)‐mediated immunotherapy. We have previously reported that knockdown IDO using siRNA can reinstall anti‐tumor immunity. However, a DC‐targeted delivery system for in vivo mobilized DCs remains to be developed, while gene silencing cancer immunotherapy has never been explored. In our study, we developed novel system, man‐GNR‐siIDO, nanocarrier specific...
We have previously reported that dephnetin is therapeutically effective in the treatment of rheumatoid arthritis (RA) collagen-induced (CIA) rat model. However, molecular mechanism and effect daphnetin on demethylating proapoptotic genes synovial cells remains further clarified. This study may provide a deeper insight into medicinal application as for RA. (1) The proliferation inhibition CIA was determined by an MTT (3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenyterazoliumromide) assay; (2)...
Aim . The RelB gene plays an important role in guiding the progression of arthritis. We have previously demonstrated that expression is decreased significantly bone marrow DCs CD38 -/- mice. In this study, we demonstrate cluster differentiation (CD38) could be a potentially therapeutic target for autoimmune Method Collagen-induced arthritis (CIA) models were generated with both wild-type (WT) C57BL/6 and maturation marrow-derived dendritic cells (DCs) from WT mice detected. Antigen-specific...
Pharmacognosy Magazine,2018,14,58,561-566.DOI:10.4103/pm.pm_523_17Published:November 2018Type:Original ArticleAuthors:Kuang Nanzhen, Wang Jieying, Zou Wenwei, Zeng Xiaoping, and Fu Yingyuan Author(s) affiliations:Kuang Nanzhen1, Jieying2, Wenwei1, Xiaoping1, Yingyuan1 1 Department of Immunology, School Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330006, China 2 330006; Laboratory, Second Affiliated Hospital Hainan College, Haikou, 570311, Abstract:Background: Numerous...
IDO2 siRNA synergizes GNR-mediated anti-melanoma photothermal therapy.
The aim of the present study was to investigate effects daphnetin combined with B cell lymphoma 2 (Bcl2)‑targeted small interfering (si)RNA (si‑Bcl2) on antiapoptotic genes in fibroblast‑like synoviocytes (FLS) rats collagen II‑induced arthritis (CIA). roles si‑Bcl2 and were determined by measuring expression levels Bcl2. Protein mRNA Bcl2 FLS flow cytometry reverse transcription‑quantitative polymerase chain reaction. Apoptosis also cytometry. It revealed that treatment or alone resulted...
Correction for ‘Synergic therapy of melanoma using GNRs-MUA-PEI/siIDO2-FA through targeted gene silencing and plasmonic photothermia’ by Yujuan Zhang <italic>et al.</italic>, <italic>RSC Adv.</italic>, 2016, <bold>6</bold>, 77577–77589.
RNA interference (RNAi) employs double-stranded or siRNA (small interfering RNA) to silence gene expression in cells. The widespread use of RNAi therapeutics requires the development clinically suitable, safe and effective delivery vehicles. PEI (Poly(ethylene imine)) carrying positive c harges has attracted considerable attention for delivery. Gold nanorods (GNRs) exhibit specially localized surface plasmon resonance when excited by visible near-infrared laser, which is useful photothermal...
To investigate the genetic polymorphisms of 6 short tandem repeats (STR) loci, namely, D6S1043, D2S1772, D7S3048, D22-GATA198B05, D8S1132 and D11S2368 in native Han population Jiangxi province, China.Two hundred twelve blood samples unrelated subjects province were collected. Genotyping was performed by using multiplex polymerase chain reaction-polyacrylamide gel electrophoresis.Thirteen alleles 52 genotypes D6S1043 locus, 13 66 12 48 11 44 10 38 D8S1132, 41 detected 212 subjects. The...
Objective To evaluate ＂main line teachingtopic design＂ based classroom discus sion method in immunology teaching. Methods Students of fiveyear class pharmacology Grade 2008 and 2009 were selected to sit the innovating The teaching methods included main teaching, topic design, discussion experimental operation. evaluation effect was analyzed by way a questionnaire comparing test scores. Results Questionnaire survey re suits show that more than 73.5% students thought helps stimulate their...
Objective To investigate the feasibility of drug sensitivity tests clinical liver cancer in vitro order to prgvide a significant experimental basis formulate reasonableindividualiziedtreatment plan.Methods 3H-thymidine incorporation assay(3H-TdR method)and MTS colorimetric assay(MTS method)were used test sensitivities SMMC-7721 and NKM-45 cell lines nine species anticancer...