A5082271687- Catalytic Cross-Coupling Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Pesticide Residue Analysis and Safety
- Synthetic Organic Chemistry Methods
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Fluorine in Organic Chemistry
- Hepatitis C virus research
- Wheat and Barley Genetics and Pathology
- Advanced biosensing and bioanalysis techniques
- Organoboron and organosilicon chemistry
- Bacteriophages and microbial interactions
- Pharmacological Effects and Assays
- Antibiotics Pharmacokinetics and Efficacy
- Coordination Chemistry and Organometallics
- Chemical Synthesis and Reactions
- Mycotoxins in Agriculture and Food
- Asymmetric Hydrogenation and Catalysis
- Pomegranate: compositions and health benefits
- Bacterial biofilms and quorum sensing
- Cancer Mechanisms and Therapy
National Institute for Biotechnology and Genetic Engineering
2016-2024
Pakistan Institute of Engineering and Applied Sciences
2019-2024
University of Faisalabad
2017-2020
University of Oxford
2008-2016
Abasyn University
2016
Oxfam
2016
Pakistan Atomic Energy Commission
2013
Mansfield University
2010
Oxford Research Group
2008-2009
Mycotoxin contamination in rice can create a health risk for the consumers. In this study, measurement of 23 mycotoxins samples (n = 180) was performed using validated LC–MS/MS method. A food frequency questionnaire used to get consumption data assessment mycotoxin dietary exposure, before calculating adults and children north south regions Pakistani Punjab province. The prevalence aflatoxin B1 (56%), B2 (48%), nivalenol (28%), diacetoxyscirpenol (23%), fumonisin (42%), zearalenone (15%),...
Analysis of regiocontrol in Pd-catalysed C–H activation leads to observations aryltrimethylsilyl and superior results with urea-based substrates.
Intramolecular assistance: Carbon-bound trimethylsilyl groups are activated intramolecularly by a carbonyl group and can participate in Heck reactions under oxidative conditions. Good stereoselectivities obtained for range of di- trisubstituted alkenes (see example). Supporting information this article is available on the WWW http://www.wiley-vch.de/contents/jc_2002/2008/z800815_s.pdf or from author. Please note: The publisher not responsible content functionality any supporting supplied...
Several closely related palladium-catalysed reactions involve the addition of Pd-C across an alkene, and subsequent β-elimination Pd-H to give a more substituted alkene. The precursor, normally possessing sp(2) carbon bound palladium, can be formed in several different ways, leading sub-classes reaction based on common principle convergent outcomes. pathway vary from simple highly subtle depending nature reactants ligation catalyst. Mechanistic analysis provides results that elucidate link...
Multidrug resistance (MDR) in the family Enterobacteriaceae is a perniciously increasing threat to global health security. The discovery of new antimicrobials having reversing drug potential may contribute augment and revive antibiotic arsenal hand. This study aimed explore anti-Enterobacteriaceae capability bioactive polyphenols from Punica granatum (P. granatum) their co-action with antibiotics against clinical isolates predominantly prevalent South Asian countries.
The Pd(II)-catalysed oxidative counterpart of the Heck reaction, originally described by Fujiwara and Moritani, has been studied in detail a combination NMR, single-crystal X-ray diffraction substrate variation. process involves palladacycle that is true intermediate catalysis. Pd(OAc)(2) first converted into more electrophilic palladium species for effective catalysis, defining main role added acid. In course these studies, three palladacyclic intermediates have characterised diffraction,...
A simple, reliable and sensitive liquid chromatography-tandem mass spectrometry-based confirmatory method was redeveloped validated for the simultaneous determination of chloramphenicol, thiamphenicol, florfenicol amine in chicken muscles. The analytes were extracted from minced muscle with acetonitrile ammoniated water mixture. second extraction ethyl acetate followed by evaporation dissolution residue methanol before defatting n-hexane. Finally, extract further cleaned up dispersive solid...
Mycotoxins, being a threat to animal and human health, contribute significantly towards economic losses in the poultry sector. A liquid chromatography-mass spectrometry-based study was conducted on feed samples collected from Punjab, Pakistan evaluate prevalence, contamination levels, co-occurrence of multi-mycotoxins across different processed forms feed, types utilities sampling regions. All were found be contaminated with aflatoxin B1 (AFB1) fumonisin (FB1). The European Commission (EC)...
Efflux‐mediated multidrug resistance is a well‐known phenomenon facilitated by resistant (MDR) transporters. One of the approaches to counteract efflux‐mediated use MDR pump inhibitors, and thus be used in combination with conventional antibiotics treat deadly diseases like typhoid fever. We have previously reported that STY4874, an efflux transporter Salmonella serotype Typhi, exhibited promising characteristics as pump. In this study, we aimed get insight into possible STY4874 inhibitors...
In this work, we report the efficient synthesis of novel (hydroxybenzoyl)pyrido[2,3-d]pyrimidine heterocycle derivatives: 6-(2-hydroxy-5-methylbenzoyl)-1-methylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (6a), 6-(5-fluoro-2-hydroxybenzoyl)-1-methylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (6b), 6-(5-ethyl-2-hydroxybenzoyl)-1-methylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (6c) and 6-(2-hydroxy-5-isopropylbenzoyl)-1-methylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (6d). The chemical structures title...
An efficient and environmentally benign synthetic protocol has been developed for the synthesis of benzo[c]pyrazolo[2,7]naphthyridine derivatives through regioselective multi-component "on-water" reaction isatin, malononitrile 3-aminopyrazole. The Knoevenagel condensation isatin with resulted in formation arylidene, which subsequently underwent Michael addition 3-aminopyrazole followed by basic hydrolysis, cyclization, decarboxylation aromatization to give target naphthyridines good...
Hepatitis C virus infection is the main cause of liver ailments across globe. Several HCV genotypes have been identified in different parts world. Effective drugs for combating infections are available but not affordable, particularly to infected individuals from resource-limited countries. Hence, cost-effective need be developed against important drug targets. As Citrus fruits naturally contain bioactive compounds with antiviral activities, current study was designed identify inhibitors...
Aim: To synthesize a novel series of norfloxacin analogs and to evaluate biological activity. Methodology: Novel were synthesized characterized by NMR mass spectrometry. Antiproliferative antioxidant properties studied. Results: Compound 2f was the most potent against HeLa cell-line with 100% inhibition cell viability IC50 = 3.1 ± 0.2 μM. All compounds exhibit moderate excellent properties. Docking study demonstrates higher binding affinity respective anticancer (B-cell lymphoma-2)...
Intramolekulare Unterstützung: An Kohlenstoffatome gebundene Trimethylsilylgruppen werden durch eine Carbonylgruppe intramolekular für oxidative Heck-Reaktionen aktiviert. Vielfältige di- und trisubstituierte Alkene reagierten mit guten Stereoselektivitäten (siehe Beispiel).
C-H activation plays a central role in organometallic catalysis. Concerted metallation-deprotonation (CMD) has been dominant as the pathway for bond cleavage. In course of studying mechanism arylamides and arylureas with Pd complexes part catalytic oxidative Heck reactions, DFT calculations were carried out. The turnover-limiting is acid-catalysed can occur readily absence acetate or other coordinating bases. simulated experiment, so that ligated sulfonate water, both previously observed by...
Abstract Background Haemorrhagic septicaemia (HS) is a highly fatal and predominant disease in livestock, particularly cattle buffalo the tropical regions of world. Pasteurella multocida ( P. ), serotypes B:2 E:2, are reported to be main causes HS wherein serotype more common Asian countries including Pakistan costs heavy financial losses every year. As yet, very little molecular genomic information related HS-associated isolated from available. Therefore, this study aimed explore...