A5050612001- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Electrohydrodynamics and Fluid Dynamics
- NF-κB Signaling Pathways
- Traumatic Brain Injury Research
- RNA Research and Splicing
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Telomeres, Telomerase, and Senescence
- Neurobiology of Language and Bilingualism
- Microbial Inactivation Methods
- Neural dynamics and brain function
- Escherichia coli research studies
- Neural Networks and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Neuroimaging Techniques and Applications
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Nanoplatforms for cancer theranostics
- Model Reduction and Neural Networks
Imperial College London
2008-2025
Queen Elizabeth University Hospital
2023
Guy's and St Thomas' NHS Foundation Trust
2020-2021
Most epigenome-wide association studies (EWAS) quantify DNA methylation (DNAm) in peripheral tissues such as whole blood to identify positions the genome where variation is statistically associated with a trait or exposure. As comprises mix of cell types, it unclear whether trait-associated DNAm specific an individual cellular population. We collected three (whole blood, buccal epithelial and nasal cells) from thirty individuals. Whole samples were subsequently processed using...
Chaos and oscillations continue to capture the interest of both scientific public domains. Yet despite importance these qualitative features, most attempts at constructing mathematical models such phenomena have taken an indirect, quantitative approach, for example, by fitting a finite number data points. Here we develop inference framework that allows us reverse-engineer design systems exhibiting other dynamical behaviours directly specifying desired characteristics underlying attractor....
The alternative lengthening of telomeres (ALT) pathway is a telomerase-independent mechanism for immortalization in cancer cells and commonly activated low-grade high-grade glioma, as well osteosarcoma. ALT can be under various conditions has often been shown to include mutational loss ATRX. However, this insufficient isolation so other cellular event must also implicated. It that excessive accumulation DNA:RNA hybrid structures (R-loops) and/or formation DNA-protein crosslinks (DPCs)...
Dendritic cell (DC)-derived cytokines play a key role in specifying adaptive immune responses tailored to the type of pathogen encountered and local tissue environment. However, little is known about how DCs perceive We investigated whether endogenous Notch signaling could affect DC pathogenic stimuli. demonstrate that concurrent TLR stimulation results unique cytokine profile mouse bone-marrow derived characterized by enhanced IL-10 IL-2, reduced IL-12 expression compared with ligation...
Abstract Supplementary motor area (SMA) syndrome is characterised by transient disturbance in volitional movement and speech production which classically occurs after injury to the medial premotor area. We present two cases of SMA following isolated surgical frontal aslant tract (FAT) with intact. The first case occurred resection a left operculum tumour. second transcortical approach ventricular neurocytoma. clinical picture fMRI activation patterns during recovery were typical for support...
Abstract Recently it has been shown that dendritic cells (DC) express both Notch and ligands, allowing for the possibility signaling may influence their maturation. We show although Jagged (Jgd) Delta-like (DlL) ligands were able to activate canonical pathway in mouse DC, only Jgd1 could induce production of certain cytokines. Maturation DC via resulted an entirely different maturation program from induced through TLR (via LPS) signaling, promoting high levels IL-2 IL-10. matured by...
Affymetrix has recently developed whole-transcript GeneChips—'Gene' and 'Exon' arrays—which interrogate exons along the length of each gene. Although probe on these arrays is intended to hybridize perfectly only one transcriptional target, many probes match multiple transcripts located in different parts genome or alternative isoforms same Existing statistical methods for estimating expression do not take this into account are thus prone producing inflated estimates. We propose a method,...
Summary/Abstract Background Most epigenome-wide association studies (EWAS) quantify DNA methylation (DNAm) in peripheral tissues such as whole blood to identify positions the genome where variation is statistically associated with a trait or exposure. As comprises mix of cell types, it unclear whether trait-associated specific an individual cellular population. Methods We collected three (whole blood, buccal and nasal epithelial cells) from thirty individuals. Whole samples were subsequently...
Gene therapy poses a great promise in treatment and prevention of variety diseases. However, crucial to studying the development this therapeutic approach is reliable efficient technique gene drug delivery into primary cell types. These cells, freshly derived from an organ or tissue, mimic more closely vivo state present physiologically relevant information compared cultured lines. cells are known be difficult transfect typically transfected using viral methods, which not only questionable...