A5047877519- Epigenetics and DNA Methylation
- Schizophrenia research and treatment
- Intergenerational Family Dynamics and Caregiving
- Diet and metabolism studies
- Family Caregiving in Mental Illness
- Scientific Research and Discoveries
- Genetic Syndromes and Imprinting
- Science, Research, and Medicine
- Genomics, phytochemicals, and oxidative stress
- Adolescent Sexual and Reproductive Health
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Health, Environment, Cognitive Aging
- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Lightning and Electromagnetic Phenomena
- Electromagnetic Compatibility and Noise Suppression
University of Exeter
2018-2021
There has been a steady increase in the number of studies aiming to identify DNA methylation differences associated with complex phenotypes. Many challenges epigenetic epidemiology regarding study design and interpretation have discussed detail, however there are analytical concerns that outstanding require further exploration. In this we seek address three issues. First, quantify multiple testing burden propose standard statistical significance threshold for identifying sites an outcome....
Abstract Depression is a common and disabling disorder, representing major social economic health issue. Moreover, depression associated with the progression of diseases an inflammatory etiology including many inflammatory-related disorders. At molecular level, mechanisms by which might promote onset these immune-dysfunction are not well understood. In this study we assessed genome-wide patterns DNA methylation in whole blood-derived obtained from individuals self-reported history (n = 100)...
Most epigenome-wide association studies (EWAS) quantify DNA methylation (DNAm) in peripheral tissues such as whole blood to identify positions the genome where variation is statistically associated with a trait or exposure. As comprises mix of cell types, it unclear whether trait-associated DNAm specific an individual cellular population. We collected three (whole blood, buccal epithelial and nasal cells) from thirty individuals. Whole samples were subsequently processed using...
Accumulating evidence suggests that individuals exposed to victimization at key developmental stages may have different epigenetic fingerprints compared those no/minimal stressful events, however results are inconclusive. This study aimed strengthen causal inference regarding the impact of adolescent on epigenome by controlling for genetic variation, age, gender, and shared environmental exposures. We conducted longitudinal epigenome-wide association analyses (EWAS) DNA methylation (DNAm)...
Schizophrenia (SCZ) is associated with high mortality. DNA methylation levels vary over the life course, and pre-selected combinations of array probes can be used to estimate "methylation age" (mAge). mAge correlates highly chronological age but when it differs, termed acceleration, has been previously all-cause We tested association between acceleration mortality in SCZ controls. selected 190 cases controls from Sweden Study. Cases were identified Swedish Hospital Discharge Register ≥5...
Summary/Abstract Background Most epigenome-wide association studies (EWAS) quantify DNA methylation (DNAm) in peripheral tissues such as whole blood to identify positions the genome where variation is statistically associated with a trait or exposure. As comprises mix of cell types, it unclear whether trait-associated specific an individual cellular population. Methods We collected three (whole blood, buccal and nasal epithelial cells) from thirty individuals. Whole samples were subsequently...
ABSTRACT Objective Psychosis - a complex and heterogeneous neuropsychiatric condition characterized by hallucinations delusions is common feature of schizophrenia. There evidence for altered DNA methylation (DNAm) associated with schizophrenia in both brain peripheral tissues. We aimed to undertake systematic analysis variable DNAm psychosis, schizophrenia, treatment-resistant also exploring measures biological ageing, smoking, blood cell composition derived from data identify molecular...